Endometrial polyp with sex cord-like pattern

De Quintal MM, Maísa Momesso De Quintal, De Angelo Andrade LA, Liliana Aparecida Lucci De Angelo Andrade
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2006 · doi:10.1097/01.pgp.0000185409.31427.07 · PMID:16633067
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-08-12 ⓘ

This report describes an endometrial polyp with a sex cord-like pattern in a postmenopausal woman on tamoxifen, noting immunohistochemistry's utility and this case's potential link to tamoxifen therapy.

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This case report describes an unusual sex cord-like pattern in an endometrial polyp from a 63-year-old postmenopausal woman who had taken tamoxifen for seven years after breast-cancer resection. Hysteroscopic biopsy identified the polyp, while hysterectomy revealed florid adenomyosis with only rare sex cord-like foci in the surrounding endometrium; immunohistochemistry was noted as useful for distinguishing these elements from metastatic breast carcinoma. The authors described this as the first reported association of this lesion with tamoxifen exposure, although the evidence is limited to a single case. This paper is centrally about adenomyosis — florid adenomyosis was identified in the hysterectomy specimen accompanying the unusual endometrial polyp.

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Abstract

We report on an unusual endometrial polyp in a postmenopausal woman taking tamoxifen for 7 years after surgical resection of a breast carcinoma. A 63-year-old woman with endometrial thickening was submitted to hysteroscopy with biopsy, which revealed a polyp with a sex cord-like pattern. The hysterectomy specimen showed florid adenomyosis, and in the background, there were rare sex cord-like foci. Immunohistochemistry can be useful in differentiating sex cord-like elements from metastatic breast cancer to endometrium. This is, to our knowledge, the first observation in literature correlated to tamoxifen intake.
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Case Reports Endometrial Polyp With Sex Cord-Like Pattern - Maísa Momesso De Quintal - Liliana Aparecida Lucci De Angelo Andrade International Journal of Gynecological Pathology 25(2):p 170-172, April 2006. | DOI: 10.1097/01.pgp.0000185409.31427.07 Summary: We report on an unusual endometrial polyp in a postmenopausal woman taking tamoxifen for 7 years after surgical resection of a breast carcinoma. A 63-year-old woman with endometrial thickening was submitted to hysteroscopy with biopsy, which revealed a polyp with a sex cord-like pattern. The hysterectomy specimen showed florid adenomyosis, and in the background, there were rare sex cord-like foci. Immunohistochemistry can be useful in differentiating sex cord-like elements from metastatic breast cancer to endometrium. This is, to our knowledge, the first observation in literature correlated to tamoxifen intake. Copyright ©2006International Society of Gynecological Pathologists

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Condition tags

adenomyosis

MeSH descriptors

Endometrial Neoplasms Endometrial Neoplasms Polyps Sex Cord-Gonadal Stromal Tumors 12E7 Antigen Antigens, CD Antigens, CD Antineoplastic Agents, Hormonal Antineoplastic Agents, Hormonal Antineoplastic Agents, Hormonal Breast Neoplasms Breast Neoplasms Breast Neoplasms Cell Adhesion Molecules Cell Adhesion Molecules Combined Modality Therapy Endometrial Neoplasms Endometrial Neoplasms Female Humans

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europepmc
last seen: 2026-08-24T06:08:07.662257+00:00
pubmed
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