Metastatic Renal Cell Carcinoma Detected by Postprandial Abdominal Pain: A Case Report

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Background: : Renal cell carcinoma (RCC), a prevalent malignancy in China, manifests annually in excess of 70,000 instances. At initial diagnosis, approximately one-tenth of these patients present with metastatic disease. The predominant sites for distant dissemination encompass pulmonary, osseous, hepatic, and adrenal regions, whereas gastric involvement remains exceedingly rare. We clinically characterized a case by postprandially abdominal discomfort, which was endoscopic-biopsy confirmed as gastric tumor, and further diagnosis revealed the primary malignancy was kidney-originated. Case report : A 68-year-old male was admitted to our hospital for the evaluation of persistent postprandial abdominal pain and diarrhea that had persisted for one month. Gastroscopy revealed a gastric body tumor, leading to the performance of an endoscopic submucosal dissection (ESD). The initial pathological examination identified the tumor as gastric malignancy of undetermined origin. Concurrently, a comprehensive abdominal CT scan detected an additional renal tumor. Subsequent radical nephrectomy of the right kidney was performed, and the pathology confirmed the renal cell carcinoma shared the same origin as the gastric lesion. Over a follow-up period of 38 months postoperatively, there has been no evidence of tumor recurrence or progression. Conclusion: : Renal cell carcinoma has the potential to metastasize to the stomach, albeit this occurrence is not readily detectable in clinical practice unless it manifests as gastric symptoms. In instances where solitary superficial gastric metastasis is identified, aggressive surgical intervention can yield satisfactory clinical outcomes.
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Metastatic Renal Cell Carcinoma Detected by Postprandial Abdominal Pain: A Case Report | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 28 February 2025 V1 Latest version Share on Metastatic Renal Cell Carcinoma Detected by Postprandial Abdominal Pain: A Case Report Authors : Xinguang Wang 0000-0002-5715-8015 , Nian Zhang , and Shaowen Zeng [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174073170.07886473/v1 Published Cancer Reports Version of record Peer review timeline 175 views 133 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background : Renal cell carcinoma (RCC), a prevalent malignancy in China, manifests annually in excess of 70,000 instances. At initial diagnosis, approximately one-tenth of these patients present with metastatic disease. The predominant sites for distant dissemination encompass pulmonary, osseous, hepatic, and adrenal regions, whereas gastric involvement remains exceedingly rare. We clinically characterized a case by postprandially abdominal discomfort, which was endoscopic-biopsy confirmed as gastric tumor, and further diagnosis revealed the primary malignancy was kidney-originated. Case report : A 68-year-old male was admitted to our hospital for the evaluation of persistent postprandial abdominal pain and diarrhea that had persisted for one month. Gastroscopy revealed a gastric body tumor, leading to the performance of an endoscopic submucosal dissection (ESD). The initial pathological examination identified the tumor as gastric malignancy of undetermined origin. Concurrently, a comprehensive abdominal CT scan detected an additional renal tumor. Subsequent radical nephrectomy of the right kidney was performed, and the pathology confirmed the renal cell carcinoma shared the same origin as the gastric lesion. Over a follow-up period of 38 months postoperatively, there has been no evidence of tumor recurrence or progression. Conclusion : Renal cell carcinoma has the potential to metastasize to the stomach, albeit this occurrence is not readily detectable in clinical practice unless it manifests as gastric symptoms. In instances where solitary superficial gastric metastasis is identified, aggressive surgical intervention can yield satisfactory clinical outcomes. Supplementary Material File (main document.doc) Download 1.32 MB Information & Authors Information Version history V1 Version 1 28 February 2025 Peer review timeline Published Cancer Reports Version of Record 9 Feb 2026 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords endoscopic submucosal dissection gastric metastasis renal cell carcinoma Authors Affiliations Xinguang Wang 0000-0002-5715-8015 Weifang People's Hospital View all articles by this author Nian Zhang Weifang People's Hospital View all articles by this author Shaowen Zeng [email protected] Weifang People's Hospital View all articles by this author Metrics & Citations Metrics Article Usage 175 views 133 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Xinguang Wang, Nian Zhang, Shaowen Zeng. Metastatic Renal Cell Carcinoma Detected by Postprandial Abdominal Pain: A Case Report. Authorea . 28 February 2025. DOI: https://doi.org/10.22541/au.174073170.07886473/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. 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