A Hyperglycemic Blood Mimicking Fluid with Good Acoustic and Physical Properties for In-Vitro Ultrasound Flow Studies

Background: A blood mimicking fluid (BMF) is made up of a mixture fluid and ultrasound scattering particles that stay neutrally buoyant in the fluid. For these particles to be able to remain suspended in the fluid, their density must be very close or equal to the density of the mixture fluid and the BMF must also have its acoustic properties (speed of sound, attenuation and backscatter power) and physical properties (density and viscosity) close to the internationally acceptable standard. This paper introduces D(+)-Glucose (DG) as an important component of a mixture fluid consisting of Propylene Glycol (PG) and water for preparing a hyperglycemic blood mimicking fluid (BMF). MethodologyThe BMF was prepared by first preparing different samples of ternary mixture fluids in which a fixed amount of PG was mixed with various amounts of water and DG to get a particular and suitable percentage combination that yielded a density similar to that of poly (4-methylstyrene) scatter particles. A required amount of the scatter particles was mixed with the suitable mixture fluid to form a BMF with good physical and acoustic properties accepted by the International Electrochemical Commission. ResultsA very good BMF was produced consisting of 84% distilled water, 5% of PG and 11% of DG as the ternary mixture fluid mixed with 0.8% Poly (4-methylstyrene) scatter particles. It has a density of 1.040 g/cm 3 , viscosity of 4.30 mpa.s, speed of sound of 1580 m/s and attenuation of 0.017 dB/cm at 5MHz, having a good back scatter property. ConclusionDG is a good substance that forms part of the ternary mixture fluid for the preparation of a hyperglycemic BMF with suitable physical and acoustic properties.