Metabolic activity organizes olfactory representations

Hearing and vision sensory systems are tuned to the natural statistics of acoustic and electromagnetic energy on earth, and are evolved to be sensitive in ethologically relevant ranges. But what are the natural statistics of odors , and how do olfactory systems exploit them? Dissecting an accurate machine learning model 1 for human odor perception, we find a computable representation for odor at the molecular level that can predict the odor-evoked receptor, neural, and behavioral responses of nearly all terrestrial organisms studied in olfactory neuroscience. Using this olfactory representation ( P rincipal O dor M ap, POM), we find that odorous compounds with similar POM representations are more likely to co-occur within a substance and be metabolically closely related; metabolic reaction sequences 2 also follow smooth paths in POM despite large jumps in molecular structure. Just as the brain’s visual representations have evolved around the natural statistics of light and shapes, the natural statistics of metabolism appear to shape the brain’s representation of the olfactory world.