A systematic review of levonorgestrel-releasing intrauterine system in the treatment of primary endometriosis

Objective To evaluate the efficacy and safety of the levonorgestrel-releasing intrauterine system(mirena) in the treatment of endometriosis.Methods Medline,Embase,The Chinese Biomedical Database(CJFD) and Chinese Science and Technology Journal Full-text Database (CSJD) from their establishment to April 2012 were employed in the study.All the studies included were evaluated by Cochrane Handbook,and homogenous studies were analyzed by Revman 5.1 software.Results Eleven studies were included.Compared with gonadotropin releasing hormone group,the mirena group had no statistical difference in visual analogue score;compared with hysterectomy group,the mirena group had statistical significance in pain relief rate;compared with expectant management group,the mirena group also had statistical significance in pain relief rate.The mirena group showed no statistical significance in adverse effect.Conclusion The mirena can significantly relieve the pain of the patients of endometriosis,and it is worth generalization in clinical.But the related studies are limited and the measure or index of these studies are different,so we look forward to more studies with high quality to prove the effectiveness of the mirena.