SFRP4 tissue and plasma expression from benign towards cancer.

Boxplots representing cumulative SFRP4 expression (arbitrary units) in cytoplasm, membrane and nucleus (SFRP4 Expression in Tissue; 3.1 A) and SFRP4 Expression (Log(SFRP4 Expression) in Plasma; 3.1 C) in plasma of patients with benign diagnosis, borderline tumors and cancers. Subdivision of the benign diagnosis group shows highest tissue expression in tubal epithelium (Tube) compared to ovarian surface epithelium (OSE) and endometriosis (3.1 B) and similar expression levels in the plasma of healthy patients (Healthy) and patients with benign tumors and endometriosis (3.1 D). Membrane-only expression of SFRP4 shows highest expression in benign tissue with a decrease in borderline tumors and a marked reduction in cancers (3.2).