Predictive Value of Lymphocyte to Monocyte Count Ratio on Complete Occlusion of Infarct-Related Arteries in Patients with Non-ST Segment Elevation Myocardial Infarction

Background: Lymphocytes and monocytes are important inflammatory cells in the body, which are involved in the whole process of the formation, progression and rupture of coronary atherosclerotic plaque. The purpose of this study was to explore the predictive value of Lymphocytes to monocytes count rate (LMR) for complete occlusion of infarct-related vessels in NSTEMI patients. Methods General information and laboratory examination data of patients with acute myocardial infarction in Henan Provincial People's Hospital from November 2020 to July 2021 were analysed. Results We evaluated 103 patients, of which 86 were males and 17 were females. There were 55 cases in complete occlusion group (CO) and 48 cases in incomplete occlusion group (IO). The shock index of CO group was significantly higher than that of IO group (0.6658 ± 0.15199 vs 0.6055 ± 0.12647, t = 2.17, P = 0.032). The APTT and LMR in CO group were significantly lower than those in IO group (28.744 ± 2.912 VS 31.072 ± 6.199, t = 2.383, p = 0.020; 3.475 ± 1.211 VS 4.634 ± 1.588, t = 4.12, p < 0.001, respectively). Univariate and multivariate logistic regression analysis showed that LMR and APTT were independent risk factors for incomplete occlusion of infarct-related vessels in NSTEMI patients (LMR OR = 1.833, 95%CI: 1.318–2.550,P < 001; APTT OR = 1.155, 95%CI: 1.018–1.309,p = 0.025 ). ROC curve was used to evaluate the predictive value of LMR for incomplete occlusion of infarct-related vessels in NSTEMI patients (AUC = 0.708, 95%CI: 0.608–0.807, P < 0.001), the positive predictive value was 79.3%, the negative predictive value was 66.2%, and the accuracy was 70.0%. Conclusions LMR has certain value in predicting whether the infarct-related vessels in NSTEMI patients are completely occluded. High LMR is an independent predictor of incomplete occlusion of infarct related vessels in NSTEMI patients. Therefore, LMR may be used in the emergency department for preoperative risk stratification of NSTEMI patients in the future.