ASSOCIATION OF IL-1Β AND IFN-Γ AND SUCCESSFUL PREGNANCY IN WOMEN UNDERGOING IN VITRO FERTILIZATION PROCEDURE

Clinical medicine ASSOCIATION OF IL-1Β AND IFN-Γ AND SUCCESSFUL PREGNANCY IN WOMEN UNDERGOING IN VITRO FERTILIZATION PROCEDURE Published 2023-02-15 Authors: AS A.F. Safarova - Abstract: - In this study, we aimed to investigate the association between immunological markers and a successful pregnancy following an in vitro fertilization procedure. A total of 131 patients were included in the study. They were grouped based on the outcome or parameters of the in vitro fertilization procedure such as successful pregnancy and female infertility. CD3, CD4, CD8, CD19, CD16/56 in the serum and cytokines in the serum and follicular aspiration fluid obtained during the process of oocyte pick-up were measured. There was no significant difference in CD3, CD4, CD8, CD19, CD16/56 levels in patients based on pregnancy outcome. IL-1β and IFN-y measurements were different in serum of patients with pregnancy and without pregnancy (p=0.041 and p=0.037, respectively). IL-1β levels were also different in the follicular aspiration fluid of patients with pregnancy and without pregnancy (p=0.039). Our study suggests an association between some cytokines (IL-1β in serum and follicular liquid) and IFN-γ (in serum)) and successful pregnancy in in vitro fertilization procedure. - Keywords: - pregnancy reproductive technologies immunological markers female infertility - References: - - Amooee S, Davoodi S, Ghasmpour L, Alamdarloo SM, Karimian A, Rahmati J. Could human chorionic gonadotropin modulate interleukin 1β to be a successful pregnancy predictor or not? JBRA assisted reproduction. 2021; 25: 44‒7. doi:10.5935/1518-0557.20200032 - CDC. 2014 Assisted reproductive technology national summary report In. Atlanta, GA, 2016. 78p. https://www.cdc.gov/art/pdf/ 2014-report/art-2014-national-summary-report.pdf - Hercor M, Anciaux M, Denanglaire S, Debuisson D, Leo O, Andris F. Antigen-presenting cell-derived IL-6 restricts the expression of GATA3 and IL-4 by follicular helper T cells. J Leukoc Biol. 2017 Jan;101(1):5‒14. doi: 10.1189/jlb.1HI1115-511R. - Hyde KJ, Schust DJ. Immunologic challenges of human reproduction: an evolving story. Fertil Steril. 2016 Sep 1;106(3):499‒510. doi: 10.1016/j.fertnstert.2016.07.1073. - Khadem N, Mansoori M, Attaran M, Attaranzadeh A, Zohdi E. Association of IL-1 and TNF-α Levels in Endometrial Secretion and Success of Embryo Transfer in IVF/ICSI Cycles. Int J Fertil Steril. 2019 Oct;13(3):236‒239. doi: 10.22074/ijfs.2019. 5668. - Kreines FM, Nasioudis D, Minis E, Irani M, Witkin SS, Spandorfer S. IL-1β predicts IVF outcome: a prospective study. J Assist Reprod Genet. 2018 Nov;35(11):2031‒2035. doi: 10.1007/s10815-018-1296-0. - Kuroda K, Nakagawa K, Horikawa T, Moriyama A, Ojiro Y, Takamizawa S, et al. Increasing number of implantation failures and pregnancy losses associated with elevated Th1/Th2 cell ratio. Am J Reprod Immunol. 2021 Sep;86(3):e13429. doi: 10.1111/aji.13429. - Lekovich J, Witkin SS, Doulaveris G, Orfanelli T, Shulman B, Pereira N, et al. Elevated serum interleukin-1β levels and interleukin-1β-to-interleukin-1 receptor antagonist ratio 1 week after embryo transfer are associated with ectopic pregnancy. Fertil Steril. 2015 Nov;104(5):1190‒4. doi: 10.1016/j.fertnstert.2015.07.1145. - Likhachov LV, Vashchenko VL, Taranovska OO, Dobrovolska LM, Makarov OG. Changes in cell-mediated and humoral immunity indices and levels of pro- and anti-inflammatory cytokines in cervical mucus in pregnant women of high risk for preeclampsia. World of Medicine and Biology. 2021; 2 (76): 79–83. http://dx.doi.org/10.26724/2079-8334-2021-2-76-79-83 - Salamonsen LA, Edgell T, Rombauts LJ, Stephens AN, Robertson DM, Rainczuk A, et al. Proteomics of the human endometrium and uterine fluid: a pathway to biomarker discovery. Fertil Steril. 2013 Mar 15;99(4):1086‒92. doi: 10.1016/j.fertnstert.2012.09.013. - Sanderman EA, Willis SK, Wise LA. Female dietary patterns and outcomes of in vitro fertilization (IVF): a systematic literature review. Nutr J. 2022 Jan 18;21(1):5. doi: 10.1186/s12937-021-00757-7. - Sequeira K, Espejel-Núñez A, Vega-Hernández E, Molina-Hernández A, Grether-González P. An increase in IL-1β concentrations in embryo culture-conditioned media obtained by in vitro fertilization on day 3 is related to successful implantation. J Assist Reprod Genet. 2015 Nov;32(11):1623‒7. doi: 10.1007/s10815-015-0573-4. - Publication: - «World of Medicine and Biology» Vol. 19 No. 83 (2023) , с. 161-164 УДК 618.256:616-036.8 How to Cite ASSOCIATION OF IL-1Β AND IFN-Γ AND SUCCESSFUL PREGNANCY IN WOMEN UNDERGOING IN VITRO FERTILIZATION PROCEDURE. (2023). World of Medicine and Biology, 19(83), 161-164. https://doi.org/10.26724/2079-8334-2023-1-83-161-164 Share