Comparison of CRISPLD2 expression in the endometrium between women with and without diagnosed endometriosis.

Jung-Yoon Yoo (462528), Heesung Shin (582242), Tae Hoon Kim (128536), Won-Seok Choi (582243), Susan D. Ferguson (462531), Asgerally T. Fazleabas (462533), Steven L. Young (513583), Bruce A. Lessey (582244), Un-Hwan Ha (35209), Jae-Wook Jeong (143654)
2015 · doi:10.1371/journal.pone.0100481.g002 · W6941760288
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This study investigated the expression levels of CRISPLD2 in endometrial tissue from women with and without diagnosed endometriosis using immunohistochemical analysis. The researchers found that CRISPLD2 is a target of the progesterone receptor and that its expression intensity was significantly decreased in the endometrium of patients with endometriosis compared to controls. This reduction in CRISPLD2 expression highlights a potential molecular alteration associated with the disease state. This paper is centrally about endometriosis — specifically examining the differential expression of CRISPLD2 in endometrial tissues between affected and unaffected women.

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Abstract

(A) Immunohistochemical analysis of CRISPLD2 in paired (a - d from women without diagnosed endometriosis; e - h from women with endometriosis) endometrium. (B) CRISPLD2 was scored by measuring expression intensity of endometrial cells. The results represent the mean ± SEM. * p<0.05
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CRISPLD2 Is a Target of Progesterone Receptor and Its Expression Is Decreased in Women with Endometriosis Figure 2 Comparison of CRISPLD2 expression in the endometrium between women with and without diagnosed endometriosis. (A) Immunohistochemical analysis of CRISPLD2 in paired (a - d from women without diagnosed endometriosis; e - h from women with endometriosis) endometrium. (B) CRISPLD2 was scored by measuring expression intensity of endometrial cells. The results represent the mean ± SEM. * p<0.05

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endometriosis

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