Diabetes mellitus indicate poor prognosis in uterine serous cancer patients

Abstract Purpose. We aimed to find prognostic factors for uterine serous cancer(USC) patients in a retrospective study.Methods. 51 USC patients between 2010-2020 were enrolled. All pathological specimens were reviewd. The research protocol was approved by Institutional Review Board and all patients were informed consent before the study began. Statistics were done using SPSS 25.0, T test and chi-square analyses were used to compare differences, the overall survival(OS) was estimated with Kaplan-Meier(KM) analysis, univariate and multivariate Cox regression analyses were utilized to find prognostic factors.Results. The median overall survival(OS) and progressive free survival(PFS) were 75.94 and 63.49 months, respectively. Diagnosed with diabetes mellitus(P=0.006, HR=6.792, 95%CI=1.726-26.722) and CA125＞28U/ml(P=0.006, HR=7.136, 95%CI=1.780-28.607) before surgery were independent risk factors for OS, advanced FIGO stage(P=0.001, HR=10.628, 95%CI=2.894-39.026) and DM(P=0.003, HR=6.327, 95%CI=1.875-21.354) were independent factors for PFS. Age≤52, , tumor size≥2.5cm and cervical mucosal infiltration may indicate poor prognosis but were not independent risk factors. Hypertension patients with routine medical treatment tend to survive longer, but there was no statistical differences in OS and PFS compared to patients with normal blood pressure.Conclusion. In addition to surgical and adjuvant treatments, gynecologists should focus more on the comorbid conditions of USC patiens, especially for DM.