Successful pregnancy resulting from cryopreserved pronuclear and cleaved embryos thawed and cultured to blastocysts, refrozen and transferred. A case report
case-report
public-domain-us
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This case report demonstrates that a live birth can result from thawing, culturing to blastocysts, refreezing, and transferring cryopreserved pronuclear and cleaved embryos in a 37-year-old woman with endometriosis.
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Abstract
BACKGROUND: Twice-frozen, thawed embryos may have utilization in vitro fertilization (IVF) cycles.
CASE: A 37-year-old woman with endometriosis and infertility returned five years after a fresh IVF cycle. Seven cryopreserved embryos (2 pronuclear [pn] and cleaved) were thawed, and five developed to the blastocyst stage. One blastocyst was transferred, and the remaining four were recryopreserved. This transfer did not result in pregnancy. The remaining four blastocysts were thawed, and two were transferred resulting in a live, singleton delivery.
CONCLUSION: Pregnancy can result from cryopreserved 2-pn and cleaved embryos cultured to blastocysts, refrozen and then transferred at the blastocyst stage.
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- europepmc
- last seen: 2026-09-18T06:10:57.818014+00:00
- pubmed
- last seen: 2026-05-13T22:12:55.732728+00:00
License: public-domain-us
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Courtesy of the U.S. National Library of Medicine
Courtesy of the U.S. National Library of Medicine