JAK-STAT pathway in hematological malignancies: achievements, challenges and future perspectives

JAK-STAT pathway in hematological malignancies: achievements, challenges and future perspectives | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 5 April 2025 V1 Latest version Share on JAK-STAT pathway in hematological malignancies: achievements, challenges and future perspectives Authors : Bing Pan , Xin Shi , Xiao Li , Bo Wang , Cheng Song , Qi Zhang , and Li Li [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174386356.66413924/v1 Published Biomedicine & Pharmacotherapy Version of record Peer review timeline 258 views 86 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Over the past few decades, the JAK-STAT signaling pathway has emerged as a focal point in the fields of cell biology and pathology. This pathway is considered one of the central communication nodes in cellular function, playing a crucial role in pro-cesses such as cell proliferation, differentiation, survival, and apoptosis. It also me-diates immune dysregulation and tumor development. Dysregulated JAK-STAT sig-naling and related gene mutations are carefully associated with the development of hematological malignancies. Therefore, in-depth research into the regulatory mech-anisms of the JAK-STAT signaling pathway and the discovery of new therapeutic targets are of great significance for the development of safer and more effective treatment strategies. Currently, the field of JAK-STAT signaling in the treatment of hematological malignancies is rapidly evolving, making it necessary to summarize this rapidly changing area so that clinicians can promptly access new strategies for disease treatment. In this review, we have revisited the current understanding of the composition, activation, and regulation of the JAK-STAT pathway and elucidated the relationship between JAK-STAT signaling components and hematological malig-nancies. The review also focuses on introducing currently FDA-approved and pre-clinical drugs designed to target this pathway, as well as discussing the current chal-lenges and directions in this field. Supplementary Material File (jak-stat pathway.docx) Download 1.88 MB Information & Authors Information Version history V1 Version 1 05 April 2025 Peer review timeline Published Biomedicine & Pharmacotherapy Version of Record 1 Feb 2026 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords blood pharmacology cancer and carcinogenesis cancer pharmacology cytokines drug delivery intracellular signaling Authors Affiliations Bing Pan The Second Hospital of Dalian Medical University View all articles by this author Xin Shi The Second Hospital of Dalian Medical University View all articles by this author Xiao Li The Second Hospital of Dalian Medical University View all articles by this author Bo Wang The Second Hospital of Dalian Medical University View all articles by this author Cheng Song The Second Hospital of Dalian Medical University View all articles by this author Qi Zhang The Second Hospital of Dalian Medical University View all articles by this author Li Li [email protected] The Second Hospital of Dalian Medical University View all articles by this author Metrics & Citations Metrics Article Usage 258 views 86 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Bing Pan, Xin Shi, Xiao Li, et al. JAK-STAT pathway in hematological malignancies: achievements, challenges and future perspectives. Authorea . 05 April 2025. DOI: https://doi.org/10.22541/au.174386356.66413924/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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