Astrocytic Biochemical Resonance and Neural-Glial Dynamics: A Mathematical Framework for Baghmaleki's Astrocytic Theory of Memory, Cognition, and Neurodegenerative Pathophysiology

Astrocytic Biochemical Resonance and Neural-Glial Dynamics: A Mathematical Framework for Baghmaleki's Astrocytic Theory of Memory, Cognition, and Neurodegenerative Pathophysiology | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 25 November 2025 V1 Latest version Share on Astrocytic Biochemical Resonance and Neural-Glial Dynamics: A Mathematical Framework for Baghmaleki's Astrocytic Theory of Memory, Cognition, and Neurodegenerative Pathophysiology Author : Majid Karimi Baghmaleki 0000-0002-3961-059X [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.176410941.13133385/v1 250 views 87 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Astrocytes have recently emerged as central players in the regulation of brain metabolism, neurotransmission, and cognitive processing. This study presents an integrative and mathematically explicit model of astrocytic-neuronal coupling based on Baghmaleki's Astrocytic Theory (Baghmaleki, 2021; 2024; 2025), proposing a dynamic framework that unites biochemical signaling, information storage, and pathological breakdown in neurodegenerative diseases. Using coupled differential equations, we describe the interaction between neuronal potential () and astrocytic energy-information potential (), incorporating nonlinear feedback functions and. Analytical exploration demonstrates conditions for resonance, bifurcation, and instability corresponding to cognitive processes and neuropathological transitions. Results suggest that astrocytic modulation of glutamate, lactate, and ion dynamics represents a biochemical memory substrate that, under metabolic dysregulation, evolves into pathological oscillations characteristic of Alzheimer's and Parkinson's diseases. This study introduces a unified mathematical-biochemical framework linking cellular metabolism, neurotransmission, and cognition. Supplementary Material File (astrocytic biochemical resonance and neural-glial dynamics.pdf) Download 331.93 KB Information & Authors Information Version history V1 Version 1 25 November 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords astrocyte-neuron coupling baghmaleki's model biochemical resonance glial metabolism mathematical neuroscience neurodegenerative diseases neurotransmitters Authors Affiliations Majid Karimi Baghmaleki 0000-0002-3961-059X [email protected] View all articles by this author Metrics & Citations Metrics Article Usage 250 views 87 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Majid Karimi Baghmaleki. Astrocytic Biochemical Resonance and Neural-Glial Dynamics: A Mathematical Framework for Baghmaleki's Astrocytic Theory of Memory, Cognition, and Neurodegenerative Pathophysiology. Authorea . 25 November 2025. DOI: https://doi.org/10.22541/au.176410941.13133385/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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