Biomarkers in endometriosis: from diagnosis to treatment

Ana Sousa, Juliandra Salumbo
In: RevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia · 2022 · vol. 4(Sup) · doi:10.51126/revsalus.v4isup.320 · W4224327068
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MUC16 and MSLN were highly expressed in all malignant ascites, while SOX2 and ALDH1 were mostly negative or low, with no correlation found between these markers and treatment regimens.

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This review article examines the potential of various biomarkers to improve the diagnosis and treatment of endometriosis. It discusses specific molecules such as CA125, matrix metalloproteinases, and factors related to inflammation and angiogenesis that are implicated in the disease's pathophysiology. The authors highlight how these biological indicators could facilitate earlier detection and more targeted therapeutic interventions for patients. This paper is centrally about endometriosis, focusing specifically on the role of biomarkers in diagnostic accuracy and treatment strategies.

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Abstract

d a s C o m u n i c a e s e m P o s t e r ALDH1, and SOX2 by immunocytochemistry in a series of malignant ascites samples (n=15) obtained from ovarian cancer patients (n=11) before (n=7) and after (n=8) treatment regiments. Results: All the malignant ascites (15 samples) present high expression levels (76 -100% of tumor cells) of MUC16 and MSLN was expressed at high levels (51 -75% and 76 -100% of tumor cells in 2/15 and 13/15 samples, respectively), both at time of diagnosis and after chemotherapy treatment. There was no clear association between MSLN and/or MUC16 with diagnosis and treatment since all cases were positive for MSLN and MUC16. In most cases, ALDH1 was negative (11/15 samples), low/moderate expressed (about 11 -25% or 25 -50% of tumor cells, respectively, in 3/15 samples), or high expressed (76 -100% of tumor cells in 1/15 samples). SOX2 was, in most cases, negative (13/15 samples). However, in two samples obtained after chemotherapy (2/7 samples) SOX2 was low/moderate expressed (about 11 -25% or 25 -50% of tumor cells, respectively). Conclusions: In summary, the expression of MUC16 and MSLN is high in all the malignant ascites samples, and SOX2 and ALDH1 were mostly negative or low/moderate expressed. We did not find a correlation with different treatment regimens.
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Biomarkers in endometriosis: from diagnosis to treatment DOI: https://doi.org/10.51126/revsalus.v4iSup.320Palavras-chave: inflamation, matrix metalloproteinases, CA125 biomarker, angiogenesis, aryl hydrocarbon receptorDownloads Os dados de download ainda não estão disponíveis. Downloads Publicado 2022-04-06 Edição Secção Pósteres Licença Este trabalho encontra-se publicado com a Licença Internacional Creative Commons Atribuição-NãoComercial-SemDerivações 4.0. Como Citar Biomarkers in endometriosis: from diagnosis to treatment. (2022). RevSALUS - Revista Científica Internacional Da Rede Académica Das Ciências Da Saúde Da Lusofonia, 4(Sup), 95-96. https://doi.org/10.51126/revsalus.v4iSup.320

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endometriosis

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