The Induction of Amenorrhoea

L J Hipkin
Journal of the Royal Army Medical Corps · 1992 · vol. 138(1) , pp. 15–18 · doi:10.1136/jramc-138-01-04 · PMID:1533675 · W1967364147
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⚙ AI-generated summary by claude@2026-06, 2026-06-12 ⓘ

This paper surveys methods for inducing amenorrhea, finding that while goserelin is effective with fewer side effects, its high cost limits its practicality compared to oral contraceptives.

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Abstract

A survey has shown that many women favour eliminating menstruation and it has been suggested that therapeutic induction of amenorrhoea might be an advantage in female personnel mobilised for war. The traditional method has been to take the oral contraceptive pill continuously. This produces weight gain and other side-effects; spotting and breakthrough bleeding can be a problem initially. The method is however cheap. The Gonadotrophin Releasing Hormone (GnRH) analogue, goserelin, is extremely effective, produces less side-effects, but it is very expensive. Two synthetic steroids, danazol and gestrinone, are moderately effective, have a variety of prominent side-effects and are also quite expensive. With all these drugs normal menstruation resumes in the cycle after they are discontinued. Although goserelin has many advantages over the continuously taken contraceptive pill, its cost precludes it from consideration as a means of eliminating menstruation.

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MeSH descriptors

Amenorrhea Contraceptives, Oral Military Personnel Amenorrhea Amenorrhea Buserelin Buserelin Buserelin Buserelin Contraceptives, Oral Contraceptives, Oral Contraceptives, Oral Danazol Danazol Female Gestrinone Gestrinone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Goserelin

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