Research Progress and Clinical Application of Dehydroabietic Acid in the Treatment of Pituitary Adenomas

This review examines the research progress and clinical applications of dehydroabietic acid in the treatment of pituitary adenomas. Pituitary adenomas, which exhibit a significant prevalence within neuroendocrine tumors, pose unique challenges in clinical management due to their diverse hormonal activity and potential for mass effects. Existing treatment modalities, including surgical interventions and pharmacotherapy, often face limitations concerning efficacy and safety, underscoring the need for alternative therapeutic strategies. Dehydroabietic acid, a compound derived from natural sources, has emerged as a promising candidate due to its pharmacological properties and demonstrated anti-tumor mechanisms. This article delves into the specific applications of dehydroabietic acid in pituitary adenomas, highlighting its single-agent efficacy as well as its synergistic potential when combined with other therapeutic approaches. By analyzing current clinical studies and experimental data, this review evaluates the therapeutic efficacy and safety profile of dehydroabietic acid in this context, while also identifying gaps in the existing literature and proposing directions for future research.