Evaluation of Serum CA_125 and Endometrial Antibody in Diagnosing Endometriosis

To evaluate serum endometrial antibody(EmAb)and CA_125 in the diagnosis of endometriosis(EMs),eighty_seven inpatients who were ready to receive laparoscopy of pelvic operation served as the object of study.Of the 87 cases,71 with EMs were served as the treatment group,and 16 with pelvic inflammatory masses as the control group.Serum concentrations of CA_125 and EmAb were examined before operation,and an optimal critical point of CA_125 was established by Receiver Operator Characteristic Curve(ROC).Results showed that the difference of CA_125 in the two groups was not significant(P 0.05 ).There was no positive correlation between CA_125 level and AFS classification of EMs(P 0.05 ).At the optimal critical point of 12.5 kU/L,serum CA_125 had a sensitivity of 53.5% and a specificity of 56.3% in the diagnosis of EMs,and EmAb had a sensitivity of 38.0% and a specificity of 87.5% .The sensitivity and specificity by parallel tests were 73.2% and 43.8% respectively,and by serial tests 18.3% and 100% respectively.It is concluded that no matter using alone or in combination,serum CA_125 and EmAb cannot achieve good sensitivity or specificity for the diagnosis of the disease.