Oncological risks of MTHFR, BRCA1 AND BRCA2 gene mutations in patients with chronic endometritis

In: Perm Medical Journal · 2019 · vol. 36(1) , pp. 45–54 · doi:10.17816/pmj36145-54 · W2940014410
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Abstract

Aim. To assess the oncological risks for the MTHFR, BRCA1 and BRCA2 gene mutation in patients with chronic endometritis. Materials and methods. Eighty six patients were examined: 33 practically healthy women and 53 patients with chronic endometritis. A part of the DNA of MTHFR (C677T, A1298C), BRCA1 (3361C > T), BRCA2 (Ser455Ser) genes was used as primers, ultrasound investigation of the mammary glands was implemented. Results. Among patients with chronic endometritis, there was detected a high rate of benign mammary gland dysplasia, chronic pathology of gastrointestinal tract organs. Conclusions. Patients with chronic endometritis have significant oncological risks, minor MTHFR and BRCA1 gene alleles were revealed in them more often than major ones, that, against the background of raised oncological pathology, acquires special significance.

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