Heart rhythm complexity impairment in end stage renal disease patients receiving haemodialysis

Heart rhythm complexity impairment in end stage renal disease patients receiving haemodialysis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Heart rhythm complexity impairment in end stage renal disease patients receiving haemodialysis Weiwei Sun, Hui Xiong, Chung-Kang Peng, Andrew C. Ahn, Qingqing Liu, and 5 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-1724891/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Cardiovascular disease (CVD) is one of the most common complications of end stage renal disease (ESRD) patients receiving haemodialysis (HD). A better understanding of the relationship between CVD and HD is important to improve life expectancy and reduce the mortality risk of ESRD patients receiving HD. Heart rate variability (HRV), also known as variations in heart rate, is a useful method to measure the autonomic nervous system dys-regulation with 24-h electrocardiogram (ECG). The variables of heart rhythm complexity could be acquired with multi-scale entropy analysis (MSE). We enrolled 31 ESRD patients receiving HD in this study. MSE was used as non-linear heart rate variability (HRV) in our study. MSE area was negative correlated with age. MSE area 10-20 was positive correlated with Kt/V, albumin (ALB) and hemoglobin (Hb). Furthermore, we found that the MSE area before HD was higher than the MSE area after HD. We also found that increased age was a deleterious factor of HRV in ESRD patients receiving HD. Kt/V, ALB, and Hb were beneficial factors of HRV in ESRD patients receiving HD. HD seemed to be a harmful factor of HRV in ESRD patients. End stage renal disease Haemodialysis Multi-scale entropy analysis Heart rate variability Factors Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-1724891","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":111951070,"identity":"8ecf2415-fe70-44e0-a432-f48383f8d38f","order_by":0,"name":"Weiwei Sun","email":"","orcid":"","institution":"Beijing University of Chinese Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Weiwei","middleName":"","lastName":"Sun","suffix":""},{"id":111951071,"identity":"63938985-3f98-47a9-846a-5daaa0dcb401","order_by":1,"name":"Hui Xiong","email":"","orcid":"","institution":"Chinese Academy of Sciences","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Hui","middleName":"","lastName":"Xiong","suffix":""},{"id":111951072,"identity":"89d18e0b-360a-482f-9841-b29da531437b","order_by":2,"name":"Chung-Kang Peng","email":"","orcid":"","institution":"Beth Israel Deaconess Medical Center, Harvard Medical School","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Chung-Kang","middleName":"","lastName":"Peng","suffix":""},{"id":111951073,"identity":"cd660a57-9679-4ca0-95e6-725114a6cc18","order_by":3,"name":"Andrew C. Ahn","email":"","orcid":"","institution":"Beth Israel Deaconess Medical Center, Harvard Medical School","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Andrew","middleName":"C.","lastName":"Ahn","suffix":""},{"id":111951074,"identity":"0c4f3e26-36a9-4679-9171-b6a9ca881724","order_by":4,"name":"Qingqing Liu","email":"","orcid":"","institution":"Beijing University of Chinese Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Qingqing","middleName":"","lastName":"Liu","suffix":""},{"id":111951075,"identity":"4246ae7b-6550-44e0-aa65-a98d38cd5697","order_by":5,"name":"Runze Yan","email":"","orcid":"","institution":"Beijing University of Chinese Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Runze","middleName":"","lastName":"Yan","suffix":""},{"id":111951076,"identity":"53a8c67e-3376-4e20-a661-2e2480d34b59","order_by":6,"name":"Qiaoru Wu","email":"","orcid":"","institution":"Beijing University of Chinese Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Qiaoru","middleName":"","lastName":"Wu","suffix":""},{"id":111951077,"identity":"38b18374-68d2-4f19-99b4-f51062ae3c9e","order_by":7,"name":"Shuwu Wei","email":"","orcid":"","institution":"Beijing University of Chinese Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Shuwu","middleName":"","lastName":"Wei","suffix":""},{"id":111951078,"identity":"0b16b0dc-538f-46d4-9467-b1ab6a0118e0","order_by":8,"name":"Kai Yuan","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAzUlEQVRIiWNgGAWjYJACxgYGCTkDCJuZeC3GJGthSNxAtBaDG8nPHs6osUjfLpH8dANDhXViA/vZAwS0pJkbbjgmkbtzRprZDYYz6YkNPHkJBLQkmEk+YJPI3XAjh+0GY9vhxAYJHgMCWtK/ST74J5FuANbyjygtOWaSG9skEiBaGojQInnmTZnkzD4Jw509z8xuJBxLN27jycGvhe94+jbJnm918ubsyc9ufKixlu1nP4Nfi8IBZF4CELPhVQ8E8g2EVIyCUTAKRsEoAAAZ7UhmZSHAMwAAAABJRU5ErkJggg==","orcid":"","institution":"Beijing University of Chinese Medicine","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Kai","middleName":"","lastName":"Yuan","suffix":""},{"id":111951079,"identity":"3385988f-c29f-483c-97eb-8de5b8d0bfd2","order_by":9,"name":"Jingwei Zhou","email":"","orcid":"","institution":"Beijing University of Chinese Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jingwei","middleName":"","lastName":"Zhou","suffix":""}],"badges":[],"createdAt":"2022-06-04 08:44:09","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-1724891/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-1724891/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":22468661,"identity":"bb4ce4fa-7fd2-4034-aac1-b6b7c1c23c89","added_by":"auto","created_at":"2022-06-09 16:18:52","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":712612,"visible":true,"origin":"","legend":"","description":"","filename":"Manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-1724891/v1_covered.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Heart rhythm complexity impairment in end stage renal disease patients receiving haemodialysis","fulltext":[{"header":"Full Text","content":"This preprint is available for \u003ca href='/article/rs-1724891/latest.pdf' target='_blank'\u003edownload as a PDF\u003c/a\u003e."}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"End stage renal disease, Haemodialysis, Multi-scale entropy analysis, Heart rate variability, Factors","lastPublishedDoi":"10.21203/rs.3.rs-1724891/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-1724891/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Cardiovascular disease (CVD) is one of the most common complications of end stage renal disease (ESRD) patients receiving haemodialysis (HD). A better understanding of the relationship between CVD and HD is important to improve life expectancy and reduce the mortality risk of ESRD patients receiving HD. Heart rate variability (HRV), also known as variations in heart rate, is a useful method to measure the autonomic nervous system dys-regulation with 24-h electrocardiogram (ECG). The variables of heart rhythm complexity could be acquired with multi-scale entropy analysis (MSE). We enrolled 31 ESRD patients receiving HD in this study. MSE was used as non-linear heart rate variability (HRV) in our study. MSE area was negative correlated with age. MSE area 10-20 was positive correlated with Kt/V, albumin (ALB) and hemoglobin (Hb). Furthermore, we found that the MSE area before HD was higher than the MSE area after HD. We also found that increased age was a deleterious factor of HRV in ESRD patients receiving HD. Kt/V, ALB, and Hb were beneficial factors of HRV in ESRD patients receiving HD. HD seemed to be a harmful factor of HRV in ESRD patients.","manuscriptTitle":"Heart rhythm complexity impairment in end stage renal disease patients receiving haemodialysis","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2022-06-09 16:18:45","doi":"10.21203/rs.3.rs-1724891/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"04bac280-5137-4ea5-8961-698356a079fe","owner":[],"postedDate":"June 9th, 2022","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2022-07-22T06:44:27+00:00","versionOfRecord":[],"versionCreatedAt":"2022-06-09 16:18:45","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-1724891","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-1724891","identity":"rs-1724891","version":["v1"]},"buildId":"FbvkV6FR0MCFSLy54lSbu","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}