Atualizações acerca da Adenomiose: evolução dos dados epidemiológicos, do diagnóstico e do tratamento nos últimos anos

In: Research, Society and Development · 2023 · vol. 12(7) , pp. e20012742804 · doi:10.33448/rsd-v12i7.42804 · W4385621847
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This review analyzes recent advances in adenomyosis epidemiology, imaging-based diagnosis, and individualized treatment strategies to improve patient care.

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This review article examines the recent evolution in epidemiological data, diagnostic methods, and treatment strategies for adenomyosis over the last few years. It highlights the shift from histopathological diagnosis following hysterectomy to non-invasive imaging techniques, with transvaginal ultrasound serving as the first-line tool for identifying focal, diffuse, deep, and superficial subtypes. The authors note that improved diagnostic capabilities allow for earlier identification and individualized treatment plans tailored to patient fertility wishes, despite the etiopathogenesis remaining incompletely understood. This paper is centrally about adenomyosis — specifically reviewing updates on its diagnosis, epidemiology, and management.

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Abstract

A adenomiose é uma condição ginecológica benigna, caracterizada pela presença de estroma e glândulas endometriais no miométrio, podendo ser caracterizada em subtipos, como focal, difusa, profunda e superficial. A etiopatogenia ainda não está completamente elucidada, mas as duas teorias mais aceitas envolvem a invaginação da camada basal do endométrio para o miométrio e a metaplasia de novo dos ductos de Muller. O diagnóstico, que antigamente era histopatológico, após a realização da histerectomia, agora pode ser feito pelos exames de imagem, sendo o ultrassom transvaginal o exame de primeira linha. A evolução do diagnóstico representou um divisor de águas para a classificação dessa patogenia, devido a melhor caracterização dos dados epidemiológicos, pela possibilidade de um melhor detalhamento do quadro clínico e pela oportunidade de identificar, com mais acurácia, essas mulheres em estágios da vida mais precoce, o que fez com que o tratamento seja, agora, individualizado, de acordo com os desejos, principalmente em relação a fertilidade, das mulheres. Dessa forma, o objetivo desse estudo é analisar o que existe de mais recente no cenário médico acerca da adenomiose, visando proporcionar um melhor cuidado para as pacientes que possuem essa doença.
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Updates on Adenomyosis: evolution of epidemiological data, diagnosis and treatment in recent years DOI: https://doi.org/10.33448/rsd-v12i7.42804Keywords: Adenomyosis, Diagnosis, Treatment, Epidemiology.Abstract Adenomyosis is a benign gynecological condition, characterized by the presence of stroma and endometrial glands in the myometrium, and can be characterized in subtypes, such as focal, diffuse, deep and superficial. The etiopathogenesis is still not fully elucidated, but the two most accepted theories involve invagination of the basal layer of the endometrium into the myometrium and de novo metaplasia of the Mullerian ducts. The diagnosis, which was formerly histopathological, after performing a hysterectomy, can now be made by imaging tests, with transvaginal ultrasound being the first-line test. The evolution of the diagnosis represented a watershed for the classification of this pathogenesis, due to the better characterization of the epidemiological data, the possibility of a better detailing of the clinical picture and the opportunity to more accurately identify these women in earlier stages of life, which meant that the treatment is now individualized, according to the wishes, especially in relation to fertility, of women. Thus, the objective of this study is to analyze what is most recent in the medical scenario about adenomyosis, aiming to provide better care for patients who have this disease. References Bourdon, M., Santulli, P., Marcellin, L., Maignien, C., Maitrot-Mantelet, L., Bordonne, C., Plu Bureau, G., & Chapron, C. (2021a). Adenomyosis: An update regarding its diagnosis and clinical features. Journal of Gynecology Obstetrics and Human Reproduction, 50(10), 102228. https://doi.org/10.1016/j.jogoh.2021.102228 Bourdon, M., Oliveira, J., Marcellin, L., Santulli, P., Bordonne, C., Maitrot Mantelet, L., Millischer, A. E., Plu Bureau, G., & Chapron, C. (2021). Adenomyosis of the inner and outer myometrium are associated with different clinical profiles. Human reproduction (Oxford, England), 36(2), 349–357. https://doi.org/10.1093/humrep/deaa307 Celli, V., Dolciami, M., Ninkova, R., Ercolani, G., Rizzo, S., Porpora, M. G., Catalano, C., & Manganaro, L. (2022). MRI and Adenomyosis: What Can Radiologists Evaluate? International Journal of Environmental Research and Public Health, 19(10), 5840. https://doi.org/10.3390/ijerph19105840 Chapron, C., Vannuccini, S., Santulli, P., Abrão, M. S., Carmona, F., Fraser, I. S., Gordts, S., Guo, S. W., Just, P. A., Noël, J. C., Pistofidis, G., Van den Bosch, T., & Petraglia, F. (2020). Diagnosing adenomyosis: an integrated clinical and imaging approach. Human reproduction update, 26(3), 392–411. https://doi.org/10.1093/humupd/dmz049 De Souza, M. T., Silva, M. D., Carvalho, R. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8(1), 102-106. Guo, S.-W., Benagiano, G., & Bazot, M. (2022). In Search of an Imaging Classification of Adenomyosis: A Role for Elastography? Journal of Clinical Medicine, 12(1), 287–287. https://doi.org/10.3390/jcm12010287 Guo, S.-W. (2022). Cracking the enigma of adenomyosis: an update on its pathogenesis and pathophysiology. Reproduction, 164(5), R101–R121. https://doi.org/10.1530/rep-22-0224 Gunther, R., & Walker, C. (2022). Adenomyosis. In StatPearls. StatPearls Publishing. Habiba, M., & Benagiano, G. (2021). Classifying Adenomyosis: Progress and Challenges. International journal of environmental research and public health, 18(23), 12386. https://doi.org/10.3390/ijerph182312386 Harada, T., Taniguchi, F., & Harada, T. (2022). Increased risk of obstetric complications in patients with adenomyosis: A narrative literature review. Reproductive medicine and biology, 21(1), e12473. https://doi.org/10.1002/rmb2.12473 Harmsen, M. J., Van den Bosch, T., de Leeuw, R. A., Dueholm, M., Exacoustos, C., Valentin, L., Hehenkamp, W. J. K., Groenman, F., De Bruyn, C., Rasmussen, C., Lazzeri, L., Jokubkiene, L., Jurkovic, D., Naftalin, J., Tellum, T., Bourne, T., Timmerman, D., & Huirne, J. A. F. (2022). Consensus on revised definitions of Morphological Uterus Sonographic Assessment (MUSA) features of adenomyosis: results of modified Delphi procedure. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 60(1), 118–131. https://doi.org/10.1002/uog.24786 Khan, K. N., Fujishita, A., & Mori, T. (2022). Pathogenesis of Human Adenomyosis: Current Understanding and Its Association with Infertility. Journal of clinical medicine, 11(14), 4057. https://doi.org/10.3390/jcm11144057. Orlov, S., & Jokubkiene, L. (2022). Prevalence of endometriosis and adenomyosis at transvaginal ultrasound examination in symptomatic women. Acta obstetricia et gynecologica Scandinavica, 101(5), 524–531. https://doi.org/10.1111/aogs.14337 Orozco, R., Vilches, J. C., Brunel, I., Lozano, M., Hernández, G., Pérez-Del Rey, D., Meloni, L., & Alcázar, J. L. (2023). Adenomyosis in Pregnancy-Should It Be Managed in High-Risk Obstetric Units?. Diagnostics (Basel, Switzerland), 13(6), 1184. https://doi.org/10.3390/diagnostics13061184 Rasmussen, C. K., Hansen, E. S., & Dueholm, M. (2019). Two- and three-dimensional ultrasonographic features related to histopathology of the uterine endometrial-myometrial junctional zone. Acta obstetricia et gynecologica Scandinavica, 98(2), 205–214. https://doi.org/10.1111/aogs.13484 Sharara, F. I., Kheil, M. H., Feki, A., Rahman, S., Klebanoff, J. S., Ayoubi, J. M., & Moawad, G. N. (2021). Current and Prospective Treatment of Adenomyosis. Journal of clinical medicine, 10(15), 3410. https://doi.org/10.3390/jcm10153410 Upson, K., & Missmer, S. A. (2020). Epidemiology of Adenomyosis. Seminars in reproductive medicine, 38(2-03), 89–107. https://doi.org/10.1055/s-0040-1718920 Van den Bosch, T., & Van Schoubroeck, D. (2018). Ultrasound diagnosis of endometriosis and adenomyosis: State of the art. Best practice & research. Clinical obstetrics & gynaecology, 51, 16–24. https://doi.org/10.1016/j.bpobgyn.2018.01.013 Vannuccini, S., & Petraglia, F. (2019). Recent advances in understanding and managing adenomyosis. F1000Research, 8, F1000 Faculty Rev-283. https://doi.org/10.12688/f1000research.17242.1. Yeh, C. C., Su, F. H., Tzeng, C. R., Muo, C. H., & Wang, W. C. (2018). Women with adenomyosis are at higher risks of endometrial and thyroid cancers: A population-based historical cohort study. PloS one, 13(3), e0194011. https://doi.org/10.1371/journal.pone.0194011 Zhai, J., Vannuccini, S., Petraglia, F., & Giudice, L. C. (2020). Adenomyosis: Mechanisms and Pathogenesis. Seminars in reproductive medicine, 38(2-03), 129–143. https://doi.org/10.1055/s-0040-1716687 Downloads Published Issue Section License Copyright (c) 2023 André Azzi Veneroso; João Vitor Dias Vasconcelos; Márcio José Rosa Requeijo This work is licensed under a Creative Commons Attribution 4.0 International License. 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