Correlation of Steroid Receptor Status and Clinical Course of Endometriosis: An Immunohistochemical Study

Yrd.doç.dr. Dilaver Demirel, Doç.dr. Richard Brown, Prof.dr. Russell Malinak, Prof.Dr. İbrahim Öztek, Ibrahim Ramzy, Prof.dr. İbrahim Ramzy
2006 · vol. 3 · W2310135508
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This immunohistochemical study found uniform estrogen and progesterone receptor expression in endometriotic lesions of patients with endometriosis, noting no significant difference in staining intensity between those who received preoperative hormonal therapy and those who did not.

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This immunohistochemical study analyzed the status of steroid receptors in endometriotic tissue to determine their correlation with the clinical course of the disease. The researchers compared estrogen and progesterone receptor levels in endometriosis lesions against normal endometrium, noting that receptor concentrations were slightly higher in ovarian lesions. The findings highlight specific hormonal profiles within ectopic endometrial tissue, providing insight into the biological mechanisms driving lesion persistence and growth. This paper is centrally about endometriosis — specifically the immunohistochemical characterization of steroid receptor expression in endometriotic tissues.

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Abstract

Endometriozisin klinik olarak gidisi ve steroid reseptor durumu arasindaki iliskiyi belirlemek amaoiyla estrogen reseptor [EFT] ve progesteron reseptor {PR} icin immun dokukimyasal boylar: endometriozisl'i 15 hastanin endometriotik lezyonlarinin (n: 1?) ve endometriumlarinin to: 3] formatinda fikse edilip paratinde bloklanan kesitlerine uygulandi. Onbes hastanin yedisine preoperatif hormonal sagaltim yapildi. Endometriumlarrn tamaminda ve 1? endometriotik lezyonun lo'sinda, bezlerde ve stromada EFi ve F'Ft icin spesifik nukleer boyanma gozlendi. Boyanma siddeti (T+-3+,l ve yayginligi t1+-4+ji semikarititatil olarak belirlendi. Preoperatif hormonal sagaltimli hastalarla, digerleri arasinda anlamli bir boyanma ayrimi gozlenmedi. Uveryumdaki ln: ?) ve ovaryum disindaki tn: to] endometrial implantlar benzer boyanma paterni gosterdi. Sonuc olarak; belirgin klinik bulgusu olan endometriozisli hastalarin endometriotik lezyonlarinda immun dokukimyasal yontemle estrogen ve progesteron reseptorlerinin uniform olarak bulundugu saptanmistir. Preoperatif hormonal sagaltim ile reseptorlerde anlamli bir azalma izlenmemistir
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Correlation of Steroid Receptor Status and Clinical Course of Endometriosis: An Immunohistochemical Study Öz Anahtar Kelimeler Kaynakça - Israel ee: Endometriosis. ln Reproductive Endocrinology. Infenility and Contraception. Edited by DR Michell. ‘v' Davajan. Philadelphia. FA Davis. 19?9: 47's. Shaw evv. Endcmetricsis: The net-d: ten years. Br J Clin Prect Symp Suppl 1991 : T2: 99—99. - Barbieri FfL. Hormone treatment of endometriosis: The estrogen threshold hypothesis. Am J Ubstet Gynecol : 199: red-s. Ftoclr. JA. lvloutos DM. Endometrlosis: the present and the future + an overview at treatment options. Br J Obstet Gynaecol 1992: 99: Suppl ?. 1—rt. - Lassey BA. Metzger DA. Haney AF. McCarty KS. lmmunohistochemical analysis of estrogen and progesterone receptors in endometrlosis: comparison with normal endometrium during the menstrual cycle and the effect of medical therapy. Fertil Steril 1999: 51: 499—19. "12 slightly higher than the levels in ovarian lesions. - ?. Lyndrup J. Thorpe S. Glenthoi A. Cihet E. et al. Altered progesteroneieslrogen receptor ratios in endometriosis. Acta Obstet Gynecol Scand 1991'; ss: 929—9. - Bergqvist A. H'annevik G. Thorali J. Estrogen and progesterone cytosol receptor concentration in andometriotic tissue and intrauterine endometriurri. Acta Dostet Gynecol Scand Suppl 1991; 191: 53-3. - Bergovist A. Jeppson 9. Ljungberg ü. Histochemical demonstration of estrogen and progesterone binding in endometrio‘tic tissue and in uterine endometrlum: a comparative study. J Histochem Cytochem 1935: 33: 51. - Jenna O. Kauppila A. Koltito E. Lahtto T. et al. Estrogen and progestin receptors in endcmetriosis lesions: comparison with endometrlel tissue. Am .J Ühstet Gynecol ; 1111:5535. o. Demirel. a. Brown. e. Marines. i. özeli. i. eamzy irem ise; sc te:—itici easy-Heisman: eer.” re cetesi-+ $"? ı “ei 3333* $ t6: ? Wifi— 9-“3199 *.“tt' *? it". i-‘f‘i‘f‘a‘: 9-35“ i' ’5‘. 't'“. >- sii-were.trees-'s.:“.itritieeweenadese-seite- sees: .ii—tsre'ireswe Ayrıntılar Birincil Dil Türkçe Konular - Bölüm - Yazarlar Yrd.doç.dr. Dilaver Demirel Bu kişi benim Doç.dr. Richard Brown Bu kişi benim Prof.dr. Russell Malinak Bu kişi benim Prof.dr. İbrahim Öztek Bu kişi benim Prof.dr. İbrahim Ramzy Bu kişi benim Yayımlanma Tarihi 1 Mayıs 1997 Gönderilme Tarihi 8 Ekim 2015 Kabul Tarihi - Yayımlandığı Sayı Yıl 1997 Cilt: 3 Sayı: 1-2

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