Soy Intake Since the Prepubertal Age May Contribute to the Pathogenesis of Endometriosis in Adulthood

Mvondo, Marie Alfrede, Ekenfack, Jessica Darelle, Minko Essono, Stéphane, Saah Namekong, Harding, Awounfack, Charline Florence, Laschke, Matthias W., Njamen, Dieudonné
2019 · doi:10.22028/d291-44170 · W6963768668
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Prepubertal female rats fed soy formulas exceeding 10% soy showed increased pelvic pain, ectopic foci volume, oxidative stress, and altered ovarian function, suggesting soy intake may promote endometriosis development.

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This study investigated whether prepubertal soy consumption influences the development of endometriosis in adulthood using an immature female rat model. Researchers fed rats various concentrations of soy formulas before inducing endometriosis via transplantation surgery at thirteen weeks of age. The results indicated that soy intake exceeding ten percent significantly increased pelvic pain intensity, expanded ectopic lesion volume, altered oxidative status, and disrupted ovarian function compared to control groups. This paper is centrally about endometriosis — specifically exploring how early-life dietary exposure to soy phytoestrogens may contribute to its pathogenesis by promoting lesion growth and associated symptoms.

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Please use this identifier to cite or link to this item: Volltext verfügbar? / Dokumentlieferung doi:10.22028/D291-44170 | Title: | Soy Intake Since the Prepubertal Age May Contribute to the Pathogenesis of Endometriosis in Adulthood | | Author(s): | Mvondo, Marie Alfrede Ekenfack, Jessica Darelle Minko Essono, Stéphane Saah Namekong, Harding Awounfack, Charline Florence Laschke, Matthias W. Njamen, Dieudonné | | Language: | English | | Title: | Journal of Medicinal Food | | Volume: | 22 | | Issue: | 6 | | Publisher/Platform: | Liebert | | Year of Publication: | 2019 | | DDC notations: | 610 Medicine and health | | Publikation type: | Journal Article | | Abstract: | High prevalence of endometriosis was reported in Asian women as a result of their traditionally high intake of soy foods during infancy. Soy is widely used in infant feeding after weaning from breast milk or cow milk. This study thus aimed to determine to what extent soy intake before puberty may contribute to the development of endometriosis. For this purpose, immature (6-week old) female rats were fed with various soy formulas (0%, 10%, 20%, 30%, 40%, 50%, and 60%). Normal control animals were fed with a soy-free diet. At 13 weeks of age, animals (except the normal control) underwent a transplantation surgery to establish endometriosis. Estradiol valerate and oxytocin were used to induce pelvic pain. Endometrial implant levels of glutathione (GSH) and malondialdehyde (MDA) allowed estimating tissue oxidative status. Physiological ovarian function was assessed by histological analysis of ovaries. Results showed that soy-fed animals grew faster than animals receiving a soy-free diet (P < .001). In animals supplemented with more than 10% of soy, the intensity of pelvic pain increased (P < .001) as well as the volume of ectopic foci. In addition, tissue levels of MDA and GSH increased (P < .001). The ovarian function was altered and the number of luteinized unruptured follicles increased. In conclusion, although animals supplemented with soy at the prepubertal stage displayed a good growth performance, regular soy consumption may promote the development and progress of endometriosis in adulthood, especially when soy content in food is more than 10%. | | DOI of the first publication: | 10.1089/jmf.2018.0160 | | URL of the first publication: | https://doi.org/10.1089/jmf.2018.0160 | | Link to this record: | urn:nbn:de:bsz:291--ds-441708 hdl:20.500.11880/39504 http://dx.doi.org/10.22028/D291-44170 | | ISSN: | 1557-7600 1096-620X | | Date of registration: | 28-Jan-2025 | | Faculty: | M - Medizinische Fakultät | | Department: | M - Chirurgie | | Professorship: | M - Prof. Dr. Michael D. Menger | | Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes | Files for this record: There are no files associated with this item. Items in SciDok are protected by copyright, with all rights reserved, unless otherwise indicated.

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