Whole-Body Networks: A Holistic Approach for Studying Aging

Abstract Aging is a multiorgan disease, yet the traditional approach is to study each organ in isolation. Such organ-specific studies allowed us to gather invaluable information regarding the pathomechanisms that contribute to senescence. But we believe that a big-picture exploration of the whole-body network (WBN) during aging could be complementary. In this study, we analyzed the functional magnetic resonance imaging (fMRI), breathing rate and heart rate time series of a young and an elderly group during eyes-open resting-state. By exploring the time-lagged coupling between the different organs we constructed WBNs. First, we showed that our analytical pipeline could identify regional differences in the networks of both populations, allowing us to proceed with the remaining of the analysis. By comparing the WBNs of young and elderly, a complex relationship emerged where some connections were stronger and some weaker in the elderly. Finally, the interconnectivity and segregation of the WBNs negatively correlated with the short-term memory of the young participants. This study: i) validated our methods, ii) identified differences between the two groups and iii) showed correlation with behavioral metrics. We are at the edge of a paradigm shift on how aging-related research is conducted and we believe that our methodology should be implemented in more complex mental and/or physical tasks to better demonstrate the alterations of WBNs as we age. Competing Interest Statement The authors have declared no competing interest. Data Availability An open dataset was used for the analysis. More information can be found out (Babayan et al. 2019).