CIRCULATING MIR-132, MIR-146A, MIR-222, AND MIR-320 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF WOMEN WITH POLYCYSTIC OVARY SYNDROME

Z Soyman, Soyman Z, S Durmus, Durmus S, Ates S, S Ates, G Simsek, Simsek G, Sozer V, V Sozer, Kundaktepe BP, B P Kundaktepe, D Kurtulus, Kurtulus D, R Gelisgen, Gelisgen R, V Sal, Sal V, Uzun H, H Uzun
Acta endocrinologica (Bucharest, Romania : 2005) · 2022 · vol. 18(1) , pp. 13–19 · doi:10.4183/aeb.2022.13 · PMID:35975247 · PMC9365421
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This case-control study found that circulating miR-132, miR-146a, and miR-222 levels were significantly downregulated in women with polycystic ovary syndrome compared to healthy controls, suggesting their potential utility in differential diagnosis.

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This prospective case-control study evaluated circulating microRNA levels to determine their utility in distinguishing women with polycystic ovary syndrome from healthy controls. The researchers measured miR-132, miR-146a, miR-222, and miR-320 alongside hormone and metabolic profiles in fifty PCOS patients and fifty matched controls. Results indicated that miR-132, miR-146a, and miR-222 were significantly downregulated in the PCOS group, while miR-320 levels showed no significant difference between groups. The authors concluded that these specific miRNAs may play a role in PCOS pathogenesis and could aid in differential diagnosis, although the study was limited by its relatively small sample size. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

PURPOSE: The aim of the study was to investigate whether the circulating miR-132, miR-146a, miR-222, and miR-320 levels are used in the differential diagnosis of women with polycystic ovary syndrome (PCOS) and healthy women. METHODS: This prospective case-control study included 50 women with PCOS and age- and body mass index- matched 50 healthy controls. The hormone and lipid profiles, levels of microRNAs (miRNAs), and parameters of carbohydrate metabolism were measured. RESULTS: Expression levels of miRNAs were assessed using the two-step quantitative real-time polymerase chain reaction. Circulating miR-132, miR-146a and miR-222 levels were significantly downregulated in the PCOS group compared with the control group. The miR-320 levels did not differ between the two groups. Free testosterone was negatively correlated with miR-132, miR-146a and miR-222. Insulin was negatively correlated with miR-132 and miR-146a. CONCLUSIONS: The results of the study revealed that miRNA expression, may suggest a possible distinction between healthy women and PCOS patients. miR-132, miR-146a, and miR-222 may have key functions in the pathogenesis of PCOS.
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- Login - Register - Home/Current Issue - About the journal - Editorial board - Online submission - Instructions for authors - Subscriptions - Foundation Acta Endocrinologica - Archive - Contact Romanian Academy The Publishing House of the Romanian Academy ACTA ENDOCRINOLOGICA (BUC) The International Journal of Romanian Society of Endocrinology / Registered in 1938in Web of Science Master Journal List Acta Endocrinologica(Bucharest) is live in PubMed Central Journal Impact Factor - click here. This Article Services Google Scholar PubMed Acta Endocrinologica (Buc) Soyman Z, Durmus S, Ates S, Simsek G, Sozer V, Kundaktepe BP, Kurtulus D, Gelisgen R, Sal V, Uzun H Circulating MIR-132, MIR-146A, MIR-222, AND MIR-320 Expression in Differential Diagnosis of Women with Polycystic Ovary Syndrome Acta Endo (Buc) 2022, 18 (1): 13-19doi: 10.4183/aeb.2022.13 Purpose. The aim of the study was to investigate whether the circulating miR-132, miR-146a, miR-222, and miR-320 levels are used in the differential diagnosis of women with polycystic ovary syndrome (PCOS) and healthy women. Methods. This prospective case-control study included 50 women with PCOS and age- and body mass index- matched 50 healthy controls. The hormone and lipid profiles, levels of microRNAs (miRNAs), and parameters of carbohydrate metabolism were measured. Results. Expression levels of miRNAs were assessed using the two-step quantitative real-time polymerase chain reaction. Circulating miR-132, miR-146a and miR- 222 levels were significantly downregulated in the PCOS group compared with the control group. The miR-320 levels did not differ between the two groups. Free testosterone was negatively correlated with miR-132, miR-146a and miR-222. Insulin was negatively correlated with miR-132 and miR-146a. Conclusions. The results of the study revealed that miRNA expression, may suggest a possible distinction between healthy women and PCOS patients. miR-132, miR-146a, and miR-222 may have key functions in the pathogenesis of PCOS. Keywords: Polycystic ovary syndrome, miR-132, miR-146a, miR-222. Correspondence: Prof. Dr. Hafize Uzun, Istanbul Atlas University, Department of Medical Biochemistry, Faculty of Medicine, Istanbul, Turkey, E-mail: [email protected]

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