Drug Delivery System for Aflibercept delivery in Metastatic ColoRectal Cancer (MCRC)

Drug Delivery System for Aflibercept delivery in Metastatic ColoRectal Cancer (MCRC) | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Drug Delivery System for Aflibercept delivery in Metastatic ColoRectal Cancer (MCRC) Seyedeh Maryam Mousavi, Hassan Jalilvand, Reza Mosaed, Hadi Tabesh This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4184685/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background : Metastatic colorectal cancer (mCRC) is a major health burden worldwide and a growing challenge in Asian countries. Treatment options include chemotherapy and a vascular endothelial growth factor (VEGF) inhibitor (such as bevacizumab, aflibercept or ramucirumab) or anti-epidermal growth factor receptor (EGFR) therapy. Aflibertcept, a recombinant fusion protein, is approved for the treatment of mCRC in combination with FOLFIRI in patients with disease progression during or after an oxaliplatin-containing regimen, based on its efficacy and tolerability profile in clinical trials. Hence, the amount and dosage and side effects of chemotherapy – even though are highly reduced - still are a counted as a great challenge. The purpose of this report is to provide an insight of the future production of a drug delivery system which can be sustainable, targeted and has less side effects. In order of achieving these goals, a DDS system was designed using electrospining method and nanoparticles filled with Aflibercept. Biological sciences/Cancer Health sciences/Diseases Health sciences/Medical research Physical sciences/Materials science Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4184685","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":285595567,"identity":"6671ecf9-3c56-4425-8d6b-e77cddaa5903","order_by":0,"name":"Seyedeh Maryam Mousavi","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA4klEQVRIiWNgGAWjYHADxsYHQJKHjxQtzQYgLWykWMMmASYJKZNv4E78XNnGEC0/I7mt8muOnQwbA/PDRzfwaDE4wLtZ8mwbQ+6GG4ltt2W3JQMdxmZsnINPCwPvBslGkBaeg223JbcxA7XwsEnj0yLfwLv5J0jL/J6DbcWS2+oJa2E4wLsNbEvD8cY2xo/bDhPWYnCYd5tlwzmJ3A3HG5ulGbcd52FjJuAX+fbezTcbymxy5zezP/z4c1u1PT9788PHeB3GDMSMkBhhYOaBiRAGfyAU4w+iVI+CUTAKRsFIAwDlPESUJmWJywAAAABJRU5ErkJggg==","orcid":"","institution":"University of Tehran","correspondingAuthor":true,"prefix":"","firstName":"Seyedeh","middleName":"Maryam","lastName":"Mousavi","suffix":""},{"id":285595569,"identity":"18c3f918-17b3-4d92-983b-961c8c05c28b","order_by":1,"name":"Hassan Jalilvand","email":"","orcid":"","institution":"Aja university of Medical sciences","correspondingAuthor":false,"prefix":"","firstName":"Hassan","middleName":"","lastName":"Jalilvand","suffix":""},{"id":285595571,"identity":"4ee29dc4-493c-4166-a38e-5823a1e05b66","order_by":2,"name":"Reza Mosaed","email":"","orcid":"","institution":"Aja university of Medical sciences","correspondingAuthor":false,"prefix":"","firstName":"Reza","middleName":"","lastName":"Mosaed","suffix":""},{"id":285595573,"identity":"71775289-7743-452f-85ed-630d54c7acd8","order_by":3,"name":"Hadi Tabesh","email":"","orcid":"","institution":"University of Tehran","correspondingAuthor":false,"prefix":"","firstName":"Hadi","middleName":"","lastName":"Tabesh","suffix":""}],"badges":[],"createdAt":"2024-03-28 22:59:12","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4184685/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4184685/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":54278363,"identity":"015c62bc-ab43-4535-8a29-67d4b52377f9","added_by":"auto","created_at":"2024-04-08 08:25:58","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":368443,"visible":true,"origin":"","legend":"","description":"","filename":"DrugDeliverySystemforAfliberceptdeliveryinMetastaticColoRectalCancer.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4184685/v1_covered_c19fce9d-957c-4fec-8d0d-8394d846e9f5.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Drug Delivery System for Aflibercept delivery in Metastatic ColoRectal Cancer (MCRC)","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-4184685/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4184685/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBackground\u003cstrong\u003e: \u003c/strong\u003eMetastatic colorectal cancer (mCRC) is a major health burden worldwide and a growing challenge in Asian countries. Treatment options include chemotherapy and a vascular endothelial growth factor (VEGF) inhibitor (such as bevacizumab, aflibercept or ramucirumab) or anti-epidermal growth factor receptor (EGFR) therapy. Aflibertcept, a recombinant fusion protein, is approved for the treatment of mCRC in combination with FOLFIRI in patients with disease progression during or after an oxaliplatin-containing regimen, based on its efficacy and tolerability profile in clinical trials. Hence, the amount and dosage and side effects of chemotherapy – even though are highly reduced - still are a counted as a great challenge. The purpose of this report is to provide an insight of the future production of a drug delivery system which can be sustainable, targeted and has less side effects. 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