The correlation between Aromatase (CYP19A1) and Bladder cancer in Chinese Han Population

Abstract BackgroundSeveral P450 metabolic enzymes genes have been discovered that affect the genetic susceptibility of bladder cancer. While, there is no report about CYP19A1 gene polymorphism on the susceptibility of bladder cancer. So, we performed a case–control study to investigate the association between polymorphisms in CYP19A1 gene and the susceptibility to bladder cancer in Chinese Han population. Materials: Five SNPs were selected and genotyped in 217 patients and 550 healthy controls. Odds ratio (OR) and 95% confidence intervals (CI) were calculated by logistic regression adjusted for age and gender.ResultsWe found that CYP19A1 rs4646 “A” allele and rs17601876 “GA” genotype added the risk of bladder cancer (rs4646: OR = 1.28, 95%CI: 1.01 - 1.62, p = 0.043; rs17601876: OR= 1.64, 95%CI: 1.17 – 2.29, p = 0.004 ), while with rs6493487 “G” and rs1062033 “G” allele in CYP19A1 gene reduced the risk of bladder cancer (rs6493487: OR = 0.68, 95%CI: 0.51 - 0.89, p = 0.005; rs1062033: OR = 0.36, 95%CI: 0.28 - 0.47, p = 9.09E-16). WHO grade stratified analysis shown that rs6493487 (OR =0.42, 95%CI: 0.23 – 0.76, p = 0.004) and rs17601876 (OR =0.44, 95%CI: 0.23 – 0.85, p = 0.015) reduced the risk of bladder cancer with WHO III-IV, when compared with the bladder cancer with WHO I-II. Age stratified analysis shown that rs4646 “A”, rs6493487 “G”, and rs1062033 “G” allele were associated with bladder cancer risk.ConclusionOur results suggested that the Aromatase CYP19A1 gene has potential roles in the genetic susceptibility to bladder cancer.