Ninjurin 2 rs118050317 gene polymorphism and endometrial cancer risk

Ninjurin 2 rs118050317 gene polymorphism and endometrial cancer risk | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Primary research Ninjurin 2 rs118050317 gene polymorphism and endometrial cancer risk Yimin Cheng, Liting Yang, Guangyao Shi, Peng Chen, Liang Li, Hangrong Fang, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-35102/v2 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 04 Jan, 2021 Read the published version in Cancer Cell International → Version 2 posted 11 You are reading this latest preprint version Show more versions Abstract Background: Endometrial cancer is one of the most common female reproductive system tumors. Ninjurin2 ( NINJ2 ) is a new adhesion factor. As a vascular susceptibility gene, it is highly expressed in other cancers and promotes the growth of cancer cells. We conducted an association analysis between NINJ2 gene polymorphism and endometrial cancer risk. Methods: Five SNPs rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368 of NINJ2 gene were genotyped in 351 endometrial cancer patients and 344 healthy controls. The clinical index difference between cases and controls were tested by one-way analysis of variance. The allele and genotype frequency of cases and controls were been compared by Chi-square test. The odds ratios (OR) with 95% confidence interval (95% CI) were examined by logistic regression analysis. Results: The SNP rs118050317 mutant allele C and homozygote CC genotype were significant increased the endometrial cancer risk (OR = 1.46, 95% CI = 1.04 – 2.06, p = 0.028; OR = 8.43, 95% CI = 1.05 – 67.89, p = 0.045). In the clinical index analysis, there were significant higher quantities of CEA, CA125 and AFP in cases serum than controls. Conclusion: The NINJ2 gene polymorphism loci rs118050317 mutant allele C was associated with an increased risk of endometrial cancer. CEA, CA125 and AFP quantities were significant higher in endometrial cancer patients. Cancer Biology Endometrial cancer Ninjurin2 Clinical index Single nucleotide polymorphisms Figures Figure 1 Introduction Endometrial cancer is malignant tumor of endometrium epithelial, which also is one of the most common female reproductive system tumors[ 1 ]. In historically, endometrial cancer was been classified as type Ⅰ (80-90%) and type Ⅱ (10-20%), in histopathological classification divided tumors into endometrioid and non-endometrioid[ 2 , 3 ]. With the development of society and the improvement of economic conditions, the incidence of endometrial cancer has also increased year by year in China[ 4 ]. Increased estrogen exposure is a major risk factor for endometrial cancer, early menarche, infertility, obesity and late menopause are associated with endometrial cancer risk, too[ 5 ]. Moreover, women with a family history of endometrial cancer have a higher risk of the disease than those without a family history, suggesting that inherited genetic factors have an impact on the incidence of endometrial cancer [ 6 ]. In the genome-wide association study of endometrial cancer, the susceptibility locus close to HNF1B on chromosome 17q was associated with endometrial cancer[ 7 ]. Vivo et al. replicated previously identified associations with genetic markers located at 17q12 (rs4430796) near the HNF1B locus[ 8 ]. Five endometrial cancer risk SNPs loci on 13q22.1, 6q22.31, 8q24.21, 15q15.1 and 14q32.33 were identified by genome-wide association study[ 9 , 10 ]. Moreover, the SNP locus in ADIPOQ , MDM2 , TP53 and leptin gene were associated with endometrial cancer, too[ 5 , 11 , 12 ], respectively. Despite there were a lot of endometrial cancer studies, the endometrium carcinogenesis remains poorly understood. Ninjurin2 ( NINJ2 ) is a transmembrane protein that mediates cell-to-cell and cell-to-extracellular matrix interactions during development, differentiation, and regeneration of nervous system, the genetic polymorphisms of NINJ2 were associated with a decreased risk of Alzheimer’s disease[ 13 ], ischemic stroke[ 14 ] and large artery atherosclerotic stroke[ 15 ]. Although there were significant association between NINJ2 gene polymorphisms and nervous system disease, but few studies were conducted between NINJ2 gene polymorphisms and cancer. The chronic inflammation may play an important role in endometrial carcinogenesis. IL-6 gene had an association with endometrial cancer risk[ 16 ]. NINJ2 can regulate the expression of IL-6 in human vascular endothelial cells. In this study we investigated whether alterations in the NINJ2 gene can influence the risk of endometrial cancer. We performed the case control study to investigate the relationship between five SNPs (rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368) of NINJ2 gene and endometrial cancer risk in Chinese women. We take A as the allele of mutant, then, the dominant model is: AA+AG compared with GG. The recessive model was: AA compared with AG+GG. The co-dominant model was: AA, AG and GG were compared. The additive model is: AA ratio GG. We used these four genetic models to study the relationship between SNPs of different genotypes and clinical indicators in patients with endometrial cancer. Materials And Methods Study population 351 endometrial cancer patients (55.66 ± 8.46) were diagnosed and selected from Shaanxi Provincial Tumor Hospital. All patients were clinical diagnosed as endometrial cancer by pathology. All cases have no radiotherapy, chemotherapy and no other cancer history. Among them, 184 were smaller than 55 years old and 167 were greater than 55 years old. 344 healthy controls (55.60 ± 8.43) were selected from the physical examination center of Tang du physical examination center. All controls have no history of cancer and age matched with cases. Among them, 178 were smaller than 55 years old and 166 were greater than 55 years old (Table 1). We collected clinical indicators of participants as much as possible, including Carcinoembryonic antigen (CEA), Carbohydrate antigen 125 (CA125), CA199, Human epididymis protein 4 (HE4), Alpha fetoprotein (AFP), Serum ferritin (SF) and Tumor necrosis factor (TNF). These clinical indicators are female tumor markers, and their dynamic changes are related to the disease, which can provide an important basis for the judgment, prognosis and treatment of the disease[ 17 , 18 ]. All participators provided informed consent and the Ethical Committee approved by the study. SNP selection and genotyping Five SNPs rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368 were selected from NINJ2 gene based on the minor allele frequency was greater than 0.05 in global population. The whole genome DNA was extracted from 5ml peripheral blood using GoldMag-Mini whole blood genomic DNA purification kit (GoldMag Co. Ltd. Xi’an City, China). The primers of genotyping were designed by Agena on-line software ( https://agenacx.com/online-tools/ ), the primer of this study were list in table 2. Agena MassARRAY platform was used to detect the five SNPs in case and control group (Agena Bioscience, SanDiego, CA, USA). Statistical analysis The clinical index quantity in serum difference was tested by one-way analysis of variance by SPSS16.0[ 19 ], see the following formula: 1) Establish test hypothesis and determine test level : H0: There was no difference between the two groups; H1: There are differences between the two groups, or they are not all equal;2) Calculate the value of statistic F: SS 1 is the mean sum of squares between the groups; SS 2 is the sum of mean squares within the group. N is the number of groups. MS 1 is between the groups; MS 2 is within the group. MS 1 = SS 1 /N-1 MS 2 = SS 2 /DATA-N F =MS 1 /MS 2 3) Determine P value and make statistical inference. The Hardy-Weinberg equilibrium (HWE) p value of each SNP in controls was calculated by exact test, p value greater than 0.05 means the sample have reached a genetic balance. The formula of Fisher's Exact test is as follows: p=(a+b)!(c+d)!(a+c)!(b+d)!/(a!b!c!d!n!) . a,b,c,d, are the data in the contingency table, respectively. The allele and genotype distribution in cases and controls were compared by Chi-square test. The odds ratios (OR) with 95% confidence interval (95% CI) were examined by logistic regression analysis before and after adjustment for age[ 20 ]. Suppose the dependent variable Z and a set of independent variables x1, x2, x3..., xn, where Z is a continuous variable, we can fit a linear equation: p(y=1) = ez/(1+ez), p(y=0) = 1/(1+ez), Z = β0 + β 1*x1 + β 2*x2 + β 3*x3 +... + β n * xn The least square method is used to estimate the value of each β coefficient. odds = p/(1-p), OR: Event occurrence probability of the experimental group (odds1)/ Occurrence rate of events in control group (odds2). The linkage disequilibrium and haplotype construction were analyzed by Haploview v4.2[ 21 ]. Results In this study, we recruited 351 endometrial cancer patients and 344 healthy controls, the age of cases and controls were matched ( p = 0.923). There were significant differences in CEA, CA125 and AFP quantity in serum between cases and controls ( p < 0.001; p = 0.048; p < 0.001). All of three clinical indicators were higher quantity in cases than controls (Table 1). In Table 3, we listed the basic information of the SNPs which including the chromosome, position, minor and common allele, the HWE p -value of all SNPs were greater than 0.05, we calculated the minor allele frequency (MAF) of cases and controls. We found compared with common G allele, the rs118050317 C allele were significant increased 0.46-fold endometrial cancer risk (OR = 1.46, 95% CI = 1.04 – 2.06, p = 0.028). In table 4, we calculated the genotype distribution in cases and controls under four different genotype model (co-dominant, dominant, recessive and log-additive) before and after adjustment the age. After adjusted the age, compared with GG genotype carriers, the rs118050317 CC genotype carriers were significant increased the endometrial cancer risk under co-dominant model (OR = 8.43, 95% CI = 1.05 – 67.89, p = 0.045), the results also significant under log-additive model (OR = 1.47, 95% CI = 1.04 – 2.07, p = 0.029) (Supplementary Table 1). In the association analysis between different SNPs and different clinical index, we found there was significant difference between rs7307242 different genotype and CEA and AFP quantity ( p = 0.021, p < 0.001), genotype AA corresponding to the highest quantity, followed by TT and AT genotype. rs75750647 different genotypes were significant associated with CA125 and CA199 quantity ( p = 0.032, p = 0.033), the AA genotype carriers had the highest CA125 and CA199 quantity. SNP loci rs11610368 different genotypes were significant associated with HE4 quantity ( p = 0.010), genotype AA corresponding to the highest quantity, followed by GG and AG (Table 5, Supplementary Table 1). Discussion In this study, we did an association study between NINJ2 gene polymorphism and endometrial cancer risk in 351 endometrial cancer patients and 344 healthy controls. We found the SNP rs118050317 mutant allele C and homozygote CC genotype were significant increased the endometrial cancer risk. In the clinical index analysis, there was significant higher quantity of CEA, CA125 and AFP in cases than controls. The gene encodes NINJ2 is located on chromosome 12p13. Toshiyuki et al showed NINJ2 is a cell surface adhesion molecule[ 22 ]. As a vascular susceptibility gene, the SNPs in NINJ2 were genotyped to test for the association between variants of NINJ2 and dementia risk. It was found that the homozygosity of two SNPs rs11833579 and rs12425791 were associated with a decreased risk of Alzheimer’s disease[ 13 ]. Moreover, the researchers also found the SNP rs12425791 of NINJ2 was significantly associated with ischemic stroke, and A allele increases the susceptibility of stroke[ 23 ]. In a family-based case control study, the A allele of rs11833579 may play a role in mediating susceptibility to ischemic stroke[ 14 ]. A functional polymorphism loci rs3809263 in the NINJ2 promoter was significant decreased the large artery atherosclerotic stroke risk. Moreover, the AA genotype carriers had significantly increased NINJ2 mRNA expression levels in Chinese population[ 15 ]. Previous study reported NINJ1 , a homologue of NINJ2 , can mediate inflammation processes[ 24 ]. In addition, NINJ2 is expressed in lymphocyte cell. Inflammation was likely to increase risk of developing endometrial cancer[ 25 ]. Wang et al found NINJ2 can regulate the express of gene that associated with inflammation in human vascular endothelial cells, such as IL-6[ 26 ]. In other study, a hypothesis about chronic inflammation may play an important role in endometrial carcinogenesis were investigated. The association between SNP in inflammatory pathway genes and endometrial cancer risk were conducted and found IL-6 SNP rs2069852 had an association with endometrial cancer risk[ 16 ]. So we speculate the rs118050317 C allele of NINJ2 through regulate the IL-6 expression to influence the ERK-NF-κB signaling pathway of endometrial cancer growth [ 27 ]. The underlying mechanism need to be further investigated. In this study, there were some limitations. First, endometrial cancer is a high incidence of female reproductive system tumors but relatively low incidence in the population. So the example size of our study was relatively small, we will collect as many samples as we can and verify our results in a larger population in future. Second, the clinical information were limited in this study, to enrich our study, we would continue to collect the information of patients and prognosis information to analyze the association between NINJ2 gene and clinical information. The underlying mechanism of NINJ2 gene involving in endometrial cancer need to be researched next step. Conclusion In conclusion, the NINJ2 gene polymorphism loci rs118050317 mutant allele C was associated with an increased risk of endometrial cancer and there was significant higher quantity in serum of CEA, CA125 and AFP in cases than controls. Abbreviations NINJ2 : Ninjurin2 ; CEA: Carcinoembryonic antigen; CA125: Carbohydrate antigen 125; AFP: Alpha fetoprotein; HE4: Human epididymis protein 4; SF: Serum ferritin; TNF: Tumor necrosis factor; MAF: minor allele frequency; OR: odds ratios; 95% CI: 95% confidence interval; HWE: hardy weinberg equilibrium; SNP: single nucleotide polymorphism; ERK: extracellular signal-regulated kinase. Declarations Acknowledgements We would like to thank all the patients and individuals in this study for their participation. We are also very grateful for the assistance of clinicians and all hospital staff of the Shaanxi Provincial Cancer Hospital and Tang du physical examination center who contributed blood samples and data for this study. Competing interest The authors declare that they have no competing interest. Funding None Availability of data and materials All the data supporting the findings of this study are contained in the manuscript. Authors’ Contributions P C and C C conceived and designed the project. YM C and L L recruited and collected study samples. LT Y selected the SNPs and designed primers. YM C and HR F performed the experiments. GY S performed and analyzed the data. YM C and LT Y wrote and revised the manuscript. Ethics approval and consent to participate The use of human blood sample and the protocol in this study were strictly comply with the criterions of the Declaration of Helsinki and were approved by the Ethics Committee of Shaanxi Provincial Tumor Hospital and Tang du physical examination center. Written informed consent was received from each participant. Consent for publication Not applicable. References Amant F, Moerman P, Neven P, Timmerman D, Van Limbergen E, Vergote I: Endometrial cancer . Lancet (London, England) 2005, 366 (9484):491-505. 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Tables Table 1 The basic information of cases and controls Variable Cases (n=351) Controls (n=344) p Age (Mean±SD) 55.66 ± 8.46 55.60 ± 8.43 0.923 ≤ 55 184 178 >55 167 166 Clinical index CEA 305 105 Quantity in serum (ng/ml) 12.55 ± 3.95 2.24 ± 3.14 <0.001* CA125 299 105 Quantity in serum (U/ml) 24.23 ± 56.30 13.25 ± 11.52 0.048* CA199 285 95 Quantity in serum (U/ml) 21.21 ± 58.23 13.91 ± 11.62 0.226 AFP 303 105 Quantity in serum (ng/ml) 9.75 ± 5.28 2.77 ± 0.97 <0.001* CEA: Carcinoembryonic antigen; CA: Carbohydrate antigen; AFP: Alpha fetoprotein * p < 0.05 indicates statistical significance Table 2 Primers used in this study SNPs 2nd-PCRP 1st-PCRP UEP_SEQ rs118050317 ACGTTGGATGGTGTAGTGATTGACACCTG ACGTTGGATGACAGGAGCTGGTCATGTTGC ggggtGCCGATGGGGAAGGATTAG rs75750647 ACGTTGGATGTGTTCGCTGTGTACTGGATG ACGTTGGATGCCCCCACAAAATTACAAACC CTAAAGCAGGGTGGAG rs7307242 ACGTTGGATGAAATGCTTCTCCTGGAAGTC ACGTTGGATGGCCCTAGCCTGTTTCTTTAG CCAGATCACTAGCTCTGA rs10849390 ACGTTGGATGTCACACAATCTCACAGGGAC ACGTTGGATGGAAATCAGTACTGCCTGTGC tcgccCAGGGACAGCCCGCTGCC rs11610368 ACGTTGGATGTCTGTGACTCCTTGCCAATG ACGTTGGATGCTCTGCAATGTTACACAGCC CCTTGCCAATGGATAGAATAGAA UEP SEQ: unextended mini‐sequencing primer Table 3 Basic information of candidate SNPs in this study SNPs Chromosome Gene Position Minor allele Common allele HWE p -Value MAF OR (95%CI) p Case Control rs118050317 12 NINJ2 634980 C G 0.336 0.129 0.092 1.46 (1.04 - 2.06) 0.028* rs75750647 12 NINJ2 638831 A G 0.617 0.333 0.314 1.09 (0.87 - 1.37) 0.440 rs7307242 12 NINJ2 641529 A T 0.197 0.138 0.149 0.92 (0.68 - 1.24) 0.576 rs10849390 12 NINJ2 646086 G A 0.638 0.372 0.360 1.05 (0.85 - 1.31) 0.646 rs11610368 12 NINJ2 662624 A G 0.053 0.127 0.130 0.97 (0.71 - 1.33) 0.869 SNP: single nucleotide polymorphisms; HWE: Hardy-Weinberg equilibrium; MAF: minor allele frequency; OR: odds ratio; 95% CI: 95% confidential interval * p < 0.05 indicates statistical significance Table 4 Genotype frequencies of the SNPs and their associations with risk of endometrial cancer SNP Model Genotype Case Control Without adjustment With adjustment of age OR (95% CI) p OR (95% CI) p rs118050317 Co-dominant GG 268 282 1 1 CG 74 61 1.28 (0.87 - 1.86) 0.206 1.28 (0.88 - 1.87) 0.202 CC 8 1 8.42 (1.05 - 67.76) 0.045* 8.43 (1.05 - 67.89) 0.045* Dominant GG 268 282 1 1 CG+CC 82 62 1.39 (0.96 - 2.01) 0.080 1.40 (0.96 - 2.02) 0.078 Recessive GG+CG 342 343 1 1 CC 8 1 8.02 (1.00 - 64.50) 0.050 8.03 (1.00 - 64.52) 0.050 Log-additive — — — 1.46 (1.04 - 2.06) 0.029* 1.47 (1.04 - 2.07) 0.029* OR: odds ratio; 95% CI: 95% confidential interval * p < 0.05 indicates statistical significance Table 5 The association between SNPs of NINJ2 and clinical index of endometrial cancer SNP Clinical Index Genotype Number in cases Quantity in blood (Mean ± SD) p rs7307242 CEA (ng/ml) AA 7 14.94 ± 3.97 0.021* AT 69 11.56 ± 3.55 TT 229 12.78 ± 4.01 AFP (ng/ml) AA 7 19.55 ± 21.16 <0.001* AT 69 9.23 ± 3.82 TT 227 9.61 ± 4.23 rs75750647 CA125 (U/ml) AA 35 46.51 ± 131.23 0.032* AG 129 24.09 ± 44.88 GG 135 18.6 ± 24.39 CA199 (U/ml) AA 31 46.19 ± 163.92 0.033* AG 124 15.9 ± 14.45 GG 130 20.32 ± 28.95 rs11610368 HE4 (pg/ml) AA 3 295.38 ± 390.97 0.010* AG 65 90.37 ± 99.74 GG 233 91.49 ± 113.83 CEA: Carcinoembryonic antigen; CA: Carbohydrate antigen; HE4: Human epididymis protein 4; AFP: Alpha fetoprotein; SF: Serum ferritin; TNF: Tumor necrosis factor * p < 0.05 indicates statistical significance Supplementary Files SupplementaryTables.docx Cite Share Download PDF Status: Published Journal Publication published 04 Jan, 2021 Read the published version in Cancer Cell International → Version 2 posted Editorial decision: Accept 07 Nov, 2020 Review # 2 received at journal 06 Nov, 2020 Reviewer # 2 agreed at journal 03 Nov, 2020 Reviewer # 3 agreed at journal 03 Nov, 2020 Reviewers invited by journal 03 Nov, 2020 Reviewer # 1 agreed at journal 03 Nov, 2020 Review # 3 received at journal 03 Nov, 2020 Review # 1 received at journal 03 Nov, 2020 Editor assigned by journal 02 Nov, 2020 Submission checks completed at journal 02 Nov, 2020 Editor invited by journal 02 Nov, 2020 You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-35102","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Primary research","associatedPublications":[],"authors":[{"id":4533030,"identity":"2c411c5e-d5bd-4abd-b834-a74289fb9410","order_by":0,"name":"Yimin Cheng","email":"","orcid":"","institution":"Northwest University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yimin","middleName":"","lastName":"Cheng","suffix":""},{"id":4533031,"identity":"1d9c6d69-6d44-4b94-973e-2c7d6464a54e","order_by":1,"name":"Liting Yang","email":"","orcid":"","institution":"Northwest University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Liting","middleName":"","lastName":"Yang","suffix":""},{"id":4533032,"identity":"878d8986-f3bc-45dd-a884-01222608e4be","order_by":2,"name":"Guangyao Shi","email":"","orcid":"","institution":"Northwest University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Guangyao","middleName":"","lastName":"Shi","suffix":""},{"id":4533033,"identity":"15ca3d1f-009d-4978-8160-c5af3a576911","order_by":3,"name":"Peng Chen","email":"","orcid":"","institution":"Northwest University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Peng","middleName":"","lastName":"Chen","suffix":""},{"id":4533034,"identity":"938ebcc2-df21-4c19-b587-8cf44d70fdb4","order_by":4,"name":"Liang Li","email":"","orcid":"","institution":"Shaanxi Provincial Tumor Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Liang","middleName":"","lastName":"Li","suffix":""},{"id":4533035,"identity":"93e5fb7e-a577-4f45-b50b-da356a771293","order_by":5,"name":"Hangrong Fang","email":"","orcid":"","institution":"xi'an NO.3 Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Hangrong","middleName":"","lastName":"Fang","suffix":""},{"id":4533036,"identity":"cbba376b-606b-44da-a061-400d0fff5075","order_by":6,"name":"Chao Chen","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA1ElEQVRIiWNgGAWjYDACCSBmbAAS7M0HHyRU1JCihedYssGDM8dI0SLhYyb5sIWZsA7+2c0PH/zcYZPHIMFjVpHYwMbA396dgN+SO8eMDXvPpBUzSLeV3UjcIcMgcebsBrxaDCQSzKQZ2w4nNsgc3nYj8QwbUCSXkJb0b0At/xMbgHoLEtuYidGSA7LlAFBLihkDUVokbuQUG/a2JSc2AANZIuHMMR6CfuGfkb7xwc82u8QGYFR+/FFRI8ff3otfCxzYH4DQPMQpHwWjYBSMglGAFwAACk9J5Fc4yBYAAAAASUVORK5CYII=","orcid":"https://orcid.org/0000-0002-7530-0871","institution":"Northwest University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Chao","middleName":"","lastName":"Chen","suffix":""}],"badges":[],"createdAt":"2020-06-12 04:39:00","currentVersionCode":2,"declarations":"","doi":"10.21203/rs.3.rs-35102/v2","doiUrl":"https://doi.org/10.21203/rs.3.rs-35102/v2","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12935-020-01646-5","type":"published","date":"2021-01-04T15:02:53+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":3572277,"identity":"20792e11-6a1a-4ce3-bf4a-1ff8090f255c","added_by":"auto","created_at":"2020-11-13 17:47:27","extension":"tif","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":2972668,"visible":true,"origin":"","legend":"Expression of NINJ2 in endometrial carcinoma. (A) The UALCAN database predicts the expression of NINJ2 in normal and cancer populations. (B) The UALCAN database predicts the expression of NINJ2 in patient’s race. (C) The GEPIA database predicts the prognosis of NINJ2 in patients. (D) The P value of the box diagram in Figure B.","description":"","filename":"FIGURE.tif","url":"https://assets-eu.researchsquare.com/files/rs-35102/v2/861c21a1f2ebfaebbfa05dec.tif"},{"id":13614735,"identity":"93d1306b-5b24-4dab-9dd1-d90eca7fd07b","added_by":"auto","created_at":"2021-09-17 06:42:20","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":3173888,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-35102/v2/7b72935f-b880-4f71-900c-780da991618a.pdf"},{"id":3572276,"identity":"b7b0fc20-aef0-461a-b1e5-5e49e75dfa95","added_by":"auto","created_at":"2020-11-13 17:47:26","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":35205,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTables.docx","url":"https://assets-eu.researchsquare.com/files/rs-35102/v2/47927ac2a331c72d5ebd8cd9.docx"}],"financialInterests":"","formattedTitle":"\u003cp\u003eNinjurin 2 rs118050317 gene polymorphism and endometrial cancer risk\u003c/p\u003e","fulltext":[{"header":"Introduction","content":"\u003cp\u003eEndometrial cancer\u0026nbsp;is malignant tumor of endometrium epithelial, which also is one of the most common female reproductive system tumors[\u003ca href=\"#_ENREF_1\" title=\"Amant, 2005 #21\"\u003e1\u003c/a\u003e]. In historically, endometrial cancer was been classified as type Ⅰ (80-90%) and type Ⅱ (10-20%), in histopathological classification divided tumors into endometrioid and non-endometrioid[\u003ca href=\"#_ENREF_2\" title=\"Colombo, 2016 #25\"\u003e2\u003c/a\u003e,\u0026nbsp;\u003ca href=\"#_ENREF_3\" title=\"Lu, 2014 #26\"\u003e3\u003c/a\u003e]. With the development of society and the improvement of economic conditions, the incidence of endometrial cancer has also increased year by year in China[\u003ca href=\"#_ENREF_4\" title=\"Gao, 2016 #16\"\u003e4\u003c/a\u003e]. Increased estrogen exposure is a major risk factor for endometrial cancer, early menarche, infertility, obesity and late menopause are associated with endometrial cancer risk, too[\u003ca href=\"#_ENREF_5\" title=\"Yoneda, 2013 #1\"\u003e5\u003c/a\u003e]. Moreover, women with a family history of endometrial cancer have a higher risk of the disease than those without a family history, suggesting that inherited genetic factors have an impact on the incidence of endometrial cancer\u0026nbsp;[\u003ca href=\"#_ENREF_6\" title=\"Win, 2015 #8\"\u003e6\u003c/a\u003e].\u003c/p\u003e\n\u003cp\u003eIn the genome-wide association study of endometrial cancer, the susceptibility locus close to \u003cem\u003eHNF1B\u003c/em\u003e on chromosome 17q was associated with endometrial cancer[\u003ca href=\"#_ENREF_7\" title=\"Spurdle, 2011 #3\"\u003e7\u003c/a\u003e]. Vivo et al. replicated previously identified associations with genetic markers located at 17q12 (rs4430796) near the \u003cem\u003eHNF1B\u003c/em\u003e locus[\u003ca href=\"#_ENREF_8\" title=\"De Vivo, 2014 #17\"\u003e8\u003c/a\u003e]. Five endometrial cancer risk SNPs loci on 13q22.1, 6q22.31, 8q24.21, 15q15.1 and 14q32.33 were identified by genome-wide association study[\u003ca href=\"#_ENREF_9\" title=\"Cheng, 2016 #2\"\u003e9\u003c/a\u003e,\u0026nbsp;\u003ca href=\"#_ENREF_10\" title=\"Painter, 2016 #4\"\u003e10\u003c/a\u003e]. Moreover, the SNP locus in \u003cem\u003eADIPOQ\u003c/em\u003e, \u003cem\u003eMDM2\u003c/em\u003e, \u003cem\u003eTP53\u003c/em\u003e and leptin gene were associated with endometrial cancer, too[\u003ca href=\"#_ENREF_5\" title=\"Yoneda, 2013 #1\"\u003e5\u003c/a\u003e,\u0026nbsp;\u003ca href=\"#_ENREF_11\" title=\"Bienkiewicz, 2016 #15\"\u003e11\u003c/a\u003e,\u0026nbsp;\u003ca href=\"#_ENREF_12\" title=\"Bienkiewicz, 2017 #18\"\u003e12\u003c/a\u003e], respectively. Despite there were a lot of endometrial cancer studies, the endometrium carcinogenesis remains poorly understood.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eNinjurin2\u003c/em\u003e (\u003cem\u003eNINJ2\u003c/em\u003e) is a transmembrane protein that mediates cell-to-cell and cell-to-extracellular matrix interactions during development, differentiation, and regeneration of nervous system, the genetic polymorphisms of \u003cem\u003eNINJ2\u003c/em\u003e were associated with a decreased risk of Alzheimer\u0026rsquo;s disease[\u003ca href=\"#_ENREF_13\" title=\"Lin, 2011 #5\"\u003e13\u003c/a\u003e], ischemic stroke[\u003ca href=\"#_ENREF_14\" title=\"Zhu, 2014 #7\"\u003e14\u003c/a\u003e]\u0026nbsp;and large artery atherosclerotic stroke[\u003ca href=\"#_ENREF_15\" title=\"Zhang, 2016 #9\"\u003e15\u003c/a\u003e]. Although there were significant association between \u003cem\u003eNINJ2\u0026nbsp;\u003c/em\u003egene polymorphisms and nervous system disease, but few studies were conducted between \u003cem\u003eNINJ2\u0026nbsp;\u003c/em\u003egene polymorphisms and cancer.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;The chronic inflammation may play an important role in endometrial carcinogenesis. IL-6 gene had an association with endometrial cancer risk[\u003ca href=\"#_ENREF_16\" title=\"Delahanty, 2013 #11\"\u003e16\u003c/a\u003e]. \u003cem\u003eNINJ2\u003c/em\u003e can regulate the expression of IL-6 in human vascular endothelial cells. In this study we investigated whether alterations in the \u003cem\u003eNINJ2\u003c/em\u003e gene can influence the risk of endometrial cancer. We performed the case control study to investigate the relationship between five SNPs (rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368) of \u003cem\u003eNINJ2\u003c/em\u003e gene and endometrial cancer risk in Chinese women. We take A as the allele of mutant, then, the dominant model is: AA+AG compared with GG. The recessive model was: AA compared with AG+GG. The co-dominant model was: AA, AG and GG were compared. The additive model is: AA ratio GG. We used these four genetic models to study the relationship between SNPs of different genotypes and clinical indicators in patients with endometrial cancer.\u0026nbsp;\u003c/p\u003e"},{"header":"Materials And Methods","content":"\u003ch2\u003eStudy population\u003c/h2\u003e\n\u003cp\u003e351 endometrial cancer patients (55.66 \u0026plusmn; 8.46) were diagnosed and selected from Shaanxi Provincial Tumor Hospital. All patients were clinical diagnosed as endometrial cancer by pathology. All cases have no radiotherapy, chemotherapy and no other cancer history. Among them, 184 were smaller than 55 years old and 167 were greater than 55 years old. 344 healthy controls (55.60 \u0026plusmn; 8.43) were selected from the physical examination center of Tang du physical examination center. All controls have no history of cancer and age matched with cases. Among them, 178 were smaller than 55 years old and 166 were greater than 55 years old (Table 1).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eWe collected clinical indicators of participants as much as possible, including Carcinoembryonic antigen (CEA), Carbohydrate antigen 125 (CA125), CA199, Human epididymis protein 4 (HE4), Alpha fetoprotein (AFP), Serum ferritin (SF) and Tumor necrosis factor (TNF). These clinical indicators are female tumor markers, and their dynamic changes are related to the disease, which can provide an important basis for the judgment, prognosis and treatment of the disease[\u003ca href=\"#_ENREF_17\" title=\"Shi, 2020 #355\"\u003e17\u003c/a\u003e,\u0026nbsp;\u003ca href=\"#_ENREF_18\" title=\"Samy, 2010 #357\"\u003e18\u003c/a\u003e].\u0026nbsp;All participators provided informed consent and the Ethical Committee approved by the study.\u003c/p\u003e\n\u003ch2\u003eSNP selection and genotyping\u003c/h2\u003e\n\u003cp\u003eFive SNPs rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368 were selected from \u003cem\u003eNINJ2\u003c/em\u003e gene based on the minor allele frequency was greater than 0.05 in global population. The whole genome DNA was extracted from 5ml peripheral blood using GoldMag-Mini whole blood genomic DNA purification kit (GoldMag Co. Ltd. Xi\u0026rsquo;an City, China). The primers of genotyping were designed by Agena on-line software (\u003ca href=\"https://agenacx.com/online-tools/\"\u003ehttps://agenacx.com/online-tools/\u003c/a\u003e), the primer of this study were list in table 2. Agena MassARRAY platform was used to detect the five SNPs in case and control group\u0026nbsp;(Agena Bioscience, SanDiego, CA, USA).\u003c/p\u003e\n\u003ch2\u003e\u003cstrong\u003eStatistical analysis\u003c/strong\u003e\u003c/h2\u003e\n\u003cp\u003eThe clinical index quantity in serum difference\u0026nbsp;was tested by one-way analysis of variance by SPSS16.0[\u003ca href=\"#_ENREF_19\" title=\"Li, 2012 #19\"\u003e19\u003c/a\u003e],\u0026nbsp;see the following formula: 1) Establish test hypothesis and determine test level : \u0026nbsp; H0: There was no difference between the two groups; H1: There are differences between the two groups, or they are not all equal;2) Calculate the value of statistic F: SS\u003csub\u003e1\u003c/sub\u003e is the mean sum of squares between the groups;\u0026nbsp;SS\u003csub\u003e2\u003c/sub\u003e is the sum of mean squares within the group.\u0026nbsp;N is the number of groups.\u0026nbsp;MS\u003csub\u003e1\u003c/sub\u003e is between the groups;\u0026nbsp;MS\u003csub\u003e2\u003c/sub\u003e is within the group.\u003c/p\u003e\n\u003cp\u003eMS\u003csub\u003e1\u003c/sub\u003e = SS\u003csub\u003e1\u003c/sub\u003e/N-1 \u0026nbsp; \u0026nbsp;\u003c/p\u003e\n\u003cp\u003eMS\u003csub\u003e2\u003c/sub\u003e= SS\u003csub\u003e2\u003c/sub\u003e /DATA-N\u003c/p\u003e\n\u003cp\u003eF =MS\u003csub\u003e1\u003c/sub\u003e/MS\u003csub\u003e2\u003c/sub\u003e\u003c/p\u003e\n\u003cp\u003e3) Determine P value and make statistical inference. The Hardy-Weinberg equilibrium (HWE) \u003cem\u003ep\u003c/em\u003e value of each SNP in controls was calculated by exact test, \u003cem\u003ep\u003c/em\u003e value greater than 0.05 means the sample have reached a genetic balance.\u0026nbsp;The formula of Fisher\u0026apos;s Exact test is as follows:\u0026nbsp;p=(a+b)!(c+d)!(a+c)!(b+d)!/(a!b!c!d!n!)\u0026nbsp;. a,b,c,d, are the data in the contingency table, respectively.\u003c/p\u003e\n\u003cp\u003eThe allele and genotype distribution in cases and controls were compared by Chi-square test. The\u0026nbsp;odds ratios (OR) with 95% confidence interval (95% CI) were examined by logistic regression analysis before and after adjustment for age[\u003ca href=\"#_ENREF_20\" title=\"Yuan, 2012 #22\"\u003e20\u003c/a\u003e]. Suppose the dependent variable Z and a set of independent variables x1, x2, x3..., xn, where Z is a continuous variable, we can fit a linear equation:\u003c/p\u003e\n\u003cp\u003ep(y=1) = ez/(1+ez),\u003c/p\u003e\n\u003cp\u003ep(y=0) = 1/(1+ez), Z = \u0026beta;0 + \u0026beta; 1*x1 + \u0026beta; 2*x2 + \u0026beta; 3*x3 +... + \u0026beta; n * xn\u003c/p\u003e\n\u003cp\u003eThe least square method is used to estimate the value of each \u0026beta; coefficient.\u003c/p\u003e\n\u003cp\u003eodds = p/(1-p), OR: Event occurrence probability of the experimental group (odds1)/ Occurrence rate of events in control group (odds2).\u003c/p\u003e\n\u003cp\u003eThe linkage disequilibrium and haplotype construction were analyzed by Haploview v4.2[\u003ca href=\"#_ENREF_21\" title=\"Li, 2018 #23\"\u003e21\u003c/a\u003e].\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eIn this study, we recruited 351 endometrial cancer patients and 344 healthy controls, the age of cases and controls were matched (\u003cem\u003ep\u0026nbsp;\u003c/em\u003e= 0.923). There were significant differences in CEA, CA125 and AFP quantity in serum between cases and controls (\u003cem\u003ep\u0026nbsp;\u003c/em\u003e\u0026lt; 0.001; \u003cem\u003ep\u0026nbsp;\u003c/em\u003e= 0.048; \u003cem\u003ep\u0026nbsp;\u003c/em\u003e\u0026lt; 0.001). All of three clinical indicators were higher quantity in cases than controls (Table 1).\u003c/p\u003e\n\u003cp\u003eIn Table\u0026nbsp;3, we listed the basic information of the SNPs which including the chromosome, position, minor and common allele, the HWE \u003cem\u003ep\u003c/em\u003e-value of all SNPs were greater than 0.05, we calculated the minor allele frequency (MAF) of cases and controls. We found compared with common G allele, the rs118050317 C allele were significant increased 0.46-fold endometrial cancer risk (OR = 1.46, 95% CI = 1.04 \u0026ndash; 2.06, \u003cem\u003ep\u003c/em\u003e = 0.028).\u003c/p\u003e\n\u003cp\u003eIn table 4, we calculated the genotype distribution in cases and controls under four different genotype model (co-dominant, dominant, recessive and log-additive) before and after adjustment the age. After adjusted the age, compared with GG genotype carriers, the rs118050317 CC genotype carriers were significant increased the endometrial cancer risk under co-dominant model (OR = 8.43, 95% CI = 1.05 \u0026ndash; 67.89, \u003cem\u003ep\u003c/em\u003e = 0.045), the results also significant under log-additive model (OR = 1.47, 95% CI = 1.04 \u0026ndash; 2.07, \u003cem\u003ep\u003c/em\u003e = 0.029) (Supplementary Table 1).\u003c/p\u003e\n\u003cp\u003eIn the association analysis between different SNPs and different clinical index, we found there was significant difference between rs7307242 different genotype and CEA and AFP quantity (\u003cem\u003ep\u003c/em\u003e = 0.021, \u003cem\u003ep\u003c/em\u003e \u0026lt; 0.001), genotype AA corresponding to the highest quantity, followed by TT and AT genotype. rs75750647 different genotypes were significant associated with CA125 and CA199 quantity (\u003cem\u003ep\u003c/em\u003e = 0.032, \u003cem\u003ep\u003c/em\u003e = 0.033), the AA genotype carriers had the highest CA125 and CA199 quantity. SNP loci rs11610368 different genotypes were significant associated with HE4 quantity (\u003cem\u003ep\u003c/em\u003e = 0.010), genotype AA corresponding to the highest quantity, followed by GG and AG (Table 5, Supplementary Table 1).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eIn this study, we did an association study between \u003cem\u003eNINJ2\u003c/em\u003e gene polymorphism and endometrial cancer risk in 351 endometrial cancer patients and 344 healthy controls. We found the SNP rs118050317 mutant allele C and homozygote CC genotype were significant increased the endometrial cancer risk. In the clinical index analysis, there was significant higher quantity of CEA, CA125 and AFP in cases than controls.\u003c/p\u003e\n\u003cp\u003eThe gene encodes \u003cem\u003eNINJ2\u003c/em\u003e is located on chromosome 12p13. Toshiyuki et al showed \u003cem\u003eNINJ2\u003c/em\u003e is a cell surface adhesion molecule[\u003ca href=\"#_ENREF_22\" title=\"Araki, 2000 #27\"\u003e22\u003c/a\u003e]. As a vascular susceptibility gene, the SNPs in \u003cem\u003eNINJ2\u0026nbsp;\u003c/em\u003ewere genotyped to test for the association between variants of \u003cem\u003eNINJ2\u003c/em\u003e and dementia risk. It was found that the homozygosity of two SNPs rs11833579 and rs12425791 were associated with a decreased risk of Alzheimer\u0026rsquo;s disease[\u003ca href=\"#_ENREF_13\" title=\"Lin, 2011 #5\"\u003e13\u003c/a\u003e]. Moreover, the researchers also found the SNP rs12425791 of \u003cem\u003eNINJ2\u003c/em\u003e was significantly associated with ischemic stroke, and A allele increases the susceptibility of stroke[\u003ca href=\"#_ENREF_23\" title=\"Wang, 2011 #14\"\u003e23\u003c/a\u003e]. In a family-based case control study, the A allele of rs11833579 may play a role in mediating susceptibility to ischemic stroke[\u003ca href=\"#_ENREF_14\" title=\"Zhu, 2014 #7\"\u003e14\u003c/a\u003e]. A functional polymorphism loci rs3809263 in the \u003cem\u003eNINJ2\u003c/em\u003e promoter was significant decreased the large artery atherosclerotic stroke risk. Moreover, the AA genotype carriers had significantly increased \u003cem\u003eNINJ2\u003c/em\u003e mRNA expression levels in Chinese population[\u003ca href=\"#_ENREF_15\" title=\"Zhang, 2016 #9\"\u003e15\u003c/a\u003e].\u003c/p\u003e\n\u003cp\u003ePrevious study reported \u003cem\u003eNINJ1\u003c/em\u003e, a homologue of \u003cem\u003eNINJ2\u003c/em\u003e, can mediate inflammation processes[\u003ca href=\"#_ENREF_24\" title=\"Ahn, 2009 #28\"\u003e24\u003c/a\u003e]. In addition, \u003cem\u003eNINJ2\u003c/em\u003e is expressed in lymphocyte cell. Inflammation was likely to increase risk of developing endometrial cancer[\u003ca href=\"#_ENREF_25\" title=\"Trabert, 2017 #29\"\u003e25\u003c/a\u003e]. Wang et al found \u003cem\u003eNINJ2\u003c/em\u003e can regulate the express of gene that associated with inflammation in human vascular endothelial cells, such as IL-6[\u003ca href=\"#_ENREF_26\" title=\"Wang, 2017 #10\"\u003e26\u003c/a\u003e]. In other study, a hypothesis about chronic inflammation may play an important role in endometrial carcinogenesis were investigated. The association between SNP in inflammatory pathway genes and endometrial cancer risk were conducted and found IL-6 SNP rs2069852 had an association with endometrial cancer risk[\u003ca href=\"#_ENREF_16\" title=\"Delahanty, 2013 #11\"\u003e16\u003c/a\u003e]. So we speculate the rs118050317 C allele of \u003cem\u003eNINJ2\u0026nbsp;\u003c/em\u003ethrough regulate the IL-6 expression to influence the ERK-NF-\u0026kappa;B signaling pathway of endometrial cancer growth\u0026nbsp;[\u003ca href=\"#_ENREF_27\" title=\"Che, 2014 #13\"\u003e27\u003c/a\u003e]. The underlying mechanism need to be further investigated.\u003c/p\u003e\n\u003cp\u003eIn this study, there were some limitations. First, endometrial cancer is a high incidence of female reproductive system tumors but relatively low incidence in the population. So the example size of our study was relatively small, we will collect as many samples as we can and verify our results in a larger population in future. Second, the clinical information were limited in this study, to enrich our study, we would continue to collect the information of patients and prognosis information to analyze the association between \u003cem\u003eNINJ2\u003c/em\u003e gene and clinical information. The underlying mechanism of \u003cem\u003eNINJ2\u003c/em\u003e gene involving in endometrial cancer need to be researched next step.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eIn conclusion, the \u003cem\u003eNINJ2\u003c/em\u003e gene polymorphism loci rs118050317 mutant allele C was associated with an increased risk of endometrial cancer and there was significant higher quantity in serum of CEA, CA125 and AFP in cases than controls.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003e\u003cem\u003eNINJ2\u003c/em\u003e: \u003cem\u003eNinjurin2\u003c/em\u003e; CEA: Carcinoembryonic antigen; CA125: Carbohydrate antigen 125; AFP: Alpha fetoprotein; HE4: Human epididymis protein 4; SF: Serum ferritin; TNF: Tumor necrosis factor; MAF: minor allele frequency; OR: odds ratios; 95% CI: 95% confidence interval; HWE: hardy weinberg equilibrium; SNP: single nucleotide polymorphism; ERK: extracellular signal-regulated kinase.\u003c/p\u003e"},{"header":"Declarations","content":"\u003ch1\u003eAcknowledgements\u003c/h1\u003e\n\u003cp\u003eWe would like to thank all the patients and individuals in this study for their participation. We are also very grateful for the assistance of clinicians and all hospital staff of\u0026nbsp;the\u0026nbsp;Shaanxi Provincial Cancer Hospital\u0026nbsp;and\u0026nbsp;Tang du physical examination center\u0026nbsp;who contributed blood samples and data for this study.\u003c/p\u003e\n\u003ch1\u003eCompeting\u0026nbsp;interest\u003c/h1\u003e\n\u003cp\u003eThe authors declare that they have no competing interest.\u003c/p\u003e\n\u003ch1\u003eFunding\u003c/h1\u003e\n\u003cp\u003eNone\u003c/p\u003e\n\u003ch1\u003eAvailability of data and materials\u003c/h1\u003e\n\u003cp\u003eAll the data supporting the findings of this study are contained in the manuscript.\u003c/p\u003e\n\u003ch1\u003eAuthors\u0026rsquo; Contributions\u003c/h1\u003e\n\u003cp\u003eP C\u0026nbsp;and C C conceived and designed the project.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eYM C\u0026nbsp;and\u0026nbsp;L L recruited and collected study samples.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eLT Y\u0026nbsp;selected the SNPs and designed primers.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eYM C\u0026nbsp;and HR F performed the experiments.\u003c/p\u003e\n\u003cp\u003eGY S\u0026nbsp;performed and analyzed the data.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u0026nbsp; \u0026nbsp;YM C and LT Y wrote and revised the manuscript.\u003c/p\u003e\n\u003ch1\u003eEthics approval and consent to participate\u003c/h1\u003e\n\u003cp\u003eThe use of human blood sample and the protocol in this study were strictly comply with the criterions of the Declaration of Helsinki and were approved by the Ethics Committee of Shaanxi Provincial Tumor Hospital\u0026nbsp;and\u0026nbsp;Tang du physical examination center. Written informed consent was received from each participant.\u003c/p\u003e\n\u003ch1\u003eConsent for publication\u003c/h1\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eAmant F, Moerman P, Neven P, Timmerman D, Van Limbergen E, Vergote I: \u003cstrong\u003eEndometrial cancer\u003c/strong\u003e. \u003cem\u003eLancet (London, England) \u003c/em\u003e2005, \u003cstrong\u003e366\u003c/strong\u003e(9484):491-505.\u003c/li\u003e\n\u003cli\u003eColombo N, Creutzberg C, Amant F, Bosse T, Gonzalez-Martin A, Ledermann J, Marth C, Nout R, Querleu D, Mirza MR\u003cem\u003e et al\u003c/em\u003e: \u003cstrong\u003eESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: Diagnosis, Treatment and Follow-up\u003c/strong\u003e. \u003cem\u003eInternational journal of gynecological cancer : official journal of the International Gynecological Cancer Society \u003c/em\u003e2016, 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Tu X\u003cem\u003e et al\u003c/em\u003e: \u003cstrong\u003eNINJ2- A novel regulator of endothelial inflammation and activation\u003c/strong\u003e. \u003cem\u003eCellular signalling \u003c/em\u003e2017, \u003cstrong\u003e35\u003c/strong\u003e:231-241.\u003c/li\u003e\n\u003cli\u003eChe Q, Liu BY, Wang FY, He YY, Lu W, Liao Y, Gu W, Wan XP: \u003cstrong\u003eInterleukin 6 promotes endometrial cancer growth through an autocrine feedback loop involving ERK-NF-kappaB signaling pathway\u003c/strong\u003e. \u003cem\u003eBiochemical and biophysical research communications \u003c/em\u003e2014, \u003cstrong\u003e446\u003c/strong\u003e(1):167-172.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style='margin-top:13.0pt;margin-right:0in;margin-bottom:13.0pt;margin-left:0in;line-height:200%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eTable 1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:200%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:14px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eThe basic information of cases and controls\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border: none;width:100.0%;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:29.94%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eVariable\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:26.56%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eCases (n=351)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.88%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eControls (n=344)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.62%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003ep\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:29.94%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eAge (Mean\u0026plusmn;SD)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:26.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e55.66 \u0026plusmn; 8.46\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.88%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e55.60 \u0026plusmn; 8.43\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.62%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.923\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:29.94%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026le;\u003c/span\u003e\u003cspan style='font-size:14px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e55\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:26.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e184\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.88%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e178\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.62%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:29.94%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026gt;55\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:26.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e167\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.88%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e166\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.62%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:29.94%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eClinical index\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:26.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.88%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.62%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:29.94%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eCEA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:26.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e305\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.88%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e105\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.62%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:29.94%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003eQuantity in serum\u003c/span\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e(ng/ml)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:26.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e12.55 \u0026plusmn; 3.95\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.88%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e2.24 \u0026plusmn; 3.14\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.62%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.001*\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:29.94%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eCA125\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:26.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e299\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.88%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e105\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.62%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:29.94%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003eQuantity in serum\u003c/span\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;(U/ml)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:26.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e24.23 \u0026plusmn; 56.30\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.88%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e13.25 \u0026plusmn; 11.52\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.62%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.048*\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:29.94%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eCA199\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:26.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e285\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.88%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e95\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.62%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:29.94%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003eQuantity in serum\u003c/span\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;(U/ml)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:26.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e21.21 \u0026plusmn; 58.23\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.88%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e13.91 \u0026plusmn; 11.62\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.62%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.226\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:29.94%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eAFP\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:26.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e303\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.88%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e105\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.62%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:29.94%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003eQuantity in serum\u003c/span\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;(ng/ml)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:26.56%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e9.75 \u0026plusmn; 5.28\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.88%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e2.77 \u0026plusmn; 0.97\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.62%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.001*\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:200%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:14px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eCEA: Carcinoembryonic antigen; CA: Carbohydrate antigen; AFP: Alpha fetoprotein\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:200%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:14px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e*\u003cem\u003ep \u0026lt;\u003c/em\u003e0.05 indicates statistical significance\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp style='margin-top:13.0pt;margin-right:0in;margin-bottom:13.0pt;margin-left:0in;line-height:200%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eTable 2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:200%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:14px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003ePrimers used in this study\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border: none;width:100.0%;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:9.44%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eSNPs\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.56%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e2nd-PCRP\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.56%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e1st-PCRP\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:25.44%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eUEP_SEQ\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:9.44%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003ers118050317\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eACGTTGGATGGTGTAGTGATTGACACCTG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eACGTTGGATGACAGGAGCTGGTCATGTTGC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:25.44%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eggggtGCCGATGGGGAAGGATTAG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:9.44%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003ers75750647\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eACGTTGGATGTGTTCGCTGTGTACTGGATG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eACGTTGGATGCCCCCACAAAATTACAAACC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:25.44%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eCTAAAGCAGGGTGGAG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:9.44%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003ers7307242\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eACGTTGGATGAAATGCTTCTCCTGGAAGTC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eACGTTGGATGGCCCTAGCCTGTTTCTTTAG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:25.44%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eCCAGATCACTAGCTCTGA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:9.44%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003ers10849390\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eACGTTGGATGTCACACAATCTCACAGGGAC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.56%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eACGTTGGATGGAAATCAGTACTGCCTGTGC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:25.44%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003etcgccCAGGGACAGCCCGCTGCC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:9.44%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003ers11610368\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.56%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eACGTTGGATGTCTGTGACTCCTTGCCAATG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.56%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eACGTTGGATGCTCTGCAATGTTACACAGCC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:25.44%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eCCTTGCCAATGGATAGAATAGAA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:200%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:14px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eUEP SEQ: unextended mini‐sequencing primer\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style='font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cbr\u003e\u0026nbsp;\u003c/span\u003e\u003cstrong style=\"font-family: Calibri, sans-serif; font-size: 15px; text-align: justify;\"\u003e\u003cspan style='font-size:16px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eTable 3\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:200%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:14px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eBasic information of candidate SNPs in this study\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border: none;width:100.0%;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:10.52%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eSNPs\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:10.8%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eChromosome\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:6.18%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eGene\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:7.22%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003ePosition\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:10.0%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eMinor allele\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:12.08%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eCommon allele\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:11.4%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eHWE \u003cem\u003ep\u003c/em\u003e-Value\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:11.96%;border:none;border-top: solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eMAF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:13.52%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eOR (95%CI)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:6.32%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003ep\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:5.48%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eCase\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eControl\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.52%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003ers118050317\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.8%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eNINJ2\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.22%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e634980\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.0%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.08%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.4%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.336\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.48%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.129\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.092\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.52%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e1.46 (1.04 - 2.06)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.32%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.028*\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.52%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003ers75750647\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.8%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eNINJ2\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.22%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e638831\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.0%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.4%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.197\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.48%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.138\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.149\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.52%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.92 (0.68 - 1.24)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.32%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.576\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.52%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003ers10849390\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.8%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eNINJ2\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.22%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e646086\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.0%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.08%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.4%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.638\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.48%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.372\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.360\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.52%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e1.05 (0.85 - 1.31)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.32%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eNINJ2\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.22%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e662624\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.0%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.08%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.4%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.053\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.48%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.127\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.130\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.52%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.97 (0.71 - 1.33)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.32%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.869\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eSNP:\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:14px;line-height:200%;font-family:\"Times New Roman\",serif;color:black;'\u003esingle nucleotide polymorphisms;\u003c/span\u003e\u003cspan style='font-size:14px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;HWE: Hardy-Weinberg equilibrium; MAF: minor allele frequency;\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:14px;line-height:200%;font-family:\"Times New Roman\",serif;color:black;'\u003eOR: odds ratio; 95% CI: 95% confidential interval\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:200%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:14px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e*\u003cem\u003ep \u0026lt;\u003c/em\u003e0.05 indicates statistical significance\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style='font-size:14px;line-height:200%;font-family:\"Calibri\",sans-serif;'\u003e\u003cbr\u003e\u0026nbsp;\u003c/span\u003e\u003cstrong style=\"font-family: Calibri, sans-serif; font-size: 15px; text-align: justify;\"\u003e\u003cspan style='font-size:16px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eTable 4\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:200%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:14px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eGenotype frequencies of the SNPs and their associations with risk of endometrial cancer\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border: none;width:100.0%;border-collapse:collapse;\"\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:12.74%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eSNP\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:12.86%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eModel\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:10.0%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eGenotype\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:6.0%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eCase\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:8.3%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eControl\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:25.06%;border:none;border-top: solid windowtext 1.0pt;padding: 0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eWithout adjustment\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:25.04%;border:none;border-top: solid windowtext 1.0pt;padding: 0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eWith adjustment of age\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:17.4%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eOR (95% CI)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.66%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003ep\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.4%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eOR (95% CI)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.64%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003ep\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:12.74%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003ers118050317\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.86%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eCo-dominant\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.0%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eGG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.0%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e268\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.3%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e282\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.4%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.66%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:17.4%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.64%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:12.74%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:12.86%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:10.0%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eCG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.0%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e74\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.3%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e61\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.4%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e1.28 (0.87 - 1.86)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.66%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.206\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.4%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e1.28 (0.88 - 1.87)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.64%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.202\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:12.74%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:12.86%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:10.0%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eCC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.0%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.3%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.4%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e8.42 (1.05 - 67.76)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.66%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.045*\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.4%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e8.43 (1.05 - 67.89)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.64%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.045*\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:12.74%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:12.86%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eDominant\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.0%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eGG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.0%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e268\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.3%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e282\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.4%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.66%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:17.4%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.64%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:12.74%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:12.86%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:10.0%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eCG+CC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.0%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e82\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.3%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e62\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.4%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e1.39 (0.96 - 2.01)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.66%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.080\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.4%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e1.40 (0.96 - 2.02)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.64%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.078\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:12.74%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:12.86%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eRecessive\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.0%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eGG+CG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.0%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e342\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.3%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e343\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.4%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.66%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:17.4%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.64%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n 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Roman\",serif;color:black;'\u003e8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.3%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.4%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e8.02 (1.00 - 64.50)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.66%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.050\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.4%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e8.03 (1.00 - 64.52)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.64%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.050\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:12.74%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:12.86%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eLog-additive\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.0%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026mdash;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.0%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026mdash;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.3%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026mdash;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.4%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e1.46 (1.04 - 2.06)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.66%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.029*\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.4%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e1.47 (1.04 - 2.07)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.64%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.029*\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:200%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:14px;line-height:200%;font-family:\"Times New Roman\",serif;color:black;'\u003eOR: odds ratio; 95% CI: 95% confidential interval\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:200%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:14px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e*\u003cem\u003ep \u0026lt;\u003c/em\u003e0.05 indicates statistical significance\u003c/span\u003e\u003cspan style='font-size:14px;line-height:200%;font-family:\"Calibri\",sans-serif;'\u003e\u003cbr\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:13.0pt;margin-right:0in;margin-bottom:13.0pt;margin-left:0in;line-height:200%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eTable 5\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:200%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:14px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eThe association between SNPs of \u003cem\u003eNINJ2\u003c/em\u003e and clinical index of endometrial cancer\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border: none;width:99.98%;border-collapse:collapse;\"\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:17.64%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eSNP\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.66%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eClinical Index\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.36%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eGenotype\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.1%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eNumber in cases\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:22.3%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eQuantity in blood\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e(Mean \u0026plusmn; SD)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.94%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003ep\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:17.64%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003ers7307242\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.66%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eCEA (ng/ml)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.36%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eAA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.1%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:22.3%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e14.94 \u0026plusmn; 3.97\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.94%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.021*\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:17.64%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.66%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:12.36%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eAT\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.1%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e69\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:22.3%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e11.56 \u0026plusmn; 3.55\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.94%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:17.64%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.66%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:12.36%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eTT\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.1%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e229\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:22.3%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e12.78 \u0026plusmn; 4.01\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.94%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:17.64%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.66%;padding:0in 5.4pt 0in 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:22.3%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e19.55 \u0026plusmn; 21.16\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.94%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.001*\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:17.64%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.66%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:12.36%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e9.23 \u0026plusmn; 3.82\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.94%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:17.64%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.66%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:12.36%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eTT\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.1%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003ers75750647\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.66%;border:none;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eCA125 (U/ml)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.36%;border:none;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eAA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.1%;border:none;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e35\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:22.3%;border:none;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e46.51 \u0026plusmn; 131.23\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.94%;border:none;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e0.032*\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:17.64%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.66%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:12.36%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003eAG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.1%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e129\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:22.3%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e24.09 \u0026plusmn; 44.88\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.94%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:17.64%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e135\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:22.3%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e18.6 \u0026plusmn; 24.39\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.94%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:17.64%;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n 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Roman\",serif;color:black;'\u003eGG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.1%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e233\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:22.3%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;line-height:115%;font-family: \"Times New Roman\",serif;color:black;'\u003e91.49 \u0026plusmn; 113.83\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.94%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:200%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:14px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eCEA: Carcinoembryonic antigen; CA: Carbohydrate antigen; HE4: Human epididymis protein 4; AFP: Alpha fetoprotein; SF: Serum ferritin; TNF: Tumor necrosis factor\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:200%;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:14px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e*\u003cem\u003ep \u0026lt;\u003c/em\u003e0.05 indicates statistical significance\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"cancer-cell-international","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"ccin","sideBox":"Learn more about [Cancer Cell International](http://cancerci.biomedcentral.com/)","snPcode":"12935","submissionUrl":"https://submission.nature.com/new-submission/12935/3","title":"Cancer Cell International","twitterHandle":"@OncoBioMed","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Endometrial cancer, Ninjurin2, Clinical index, Single nucleotide polymorphisms","lastPublishedDoi":"10.21203/rs.3.rs-35102/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-35102/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003e Endometrial cancer is one of the most common female reproductive system tumors. \u003cem\u003eNinjurin2\u003c/em\u003e (\u003cem\u003eNINJ2\u003c/em\u003e) is a new adhesion factor. As a vascular susceptibility gene, it is highly expressed in other cancers and promotes the growth of cancer cells. We conducted an association analysis between \u003cem\u003eNINJ2\u003c/em\u003e gene polymorphism and endometrial cancer risk.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods: \u003c/strong\u003eFive SNPs rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368 of \u003cem\u003eNINJ2\u003c/em\u003e gene were genotyped in 351 endometrial cancer patients and 344 healthy controls. The clinical index difference between cases and controls were tested by one-way analysis of variance. The allele and genotype frequency of cases and controls were been compared by Chi-square test. The odds ratios (OR) with 95% confidence interval (95% CI) were examined by logistic regression analysis. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults: \u003c/strong\u003eThe SNP rs118050317 mutant allele C and homozygote CC genotype were significant increased the endometrial cancer risk (OR = 1.46, 95% CI = 1.04 – 2.06, \u003cem\u003ep\u003c/em\u003e = 0.028; OR = 8.43, 95% CI = 1.05 – 67.89, \u003cem\u003ep\u003c/em\u003e = 0.045). In the clinical index analysis, there were significant higher quantities of CEA, CA125 and AFP in cases serum than controls.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusion:\u003c/strong\u003e The \u003cem\u003eNINJ2\u003c/em\u003e gene polymorphism loci rs118050317 mutant allele C was associated with an increased risk of endometrial cancer. CEA, CA125 and AFP quantities were significant higher in endometrial cancer patients.\u003c/p\u003e","manuscriptTitle":"Ninjurin 2 rs118050317 gene polymorphism and endometrial cancer risk","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2020-11-13 17:47:25","doi":"10.21203/rs.3.rs-35102/v2","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Accept","date":"2020-11-08T00:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-11-07T00:00:00+00:00","index":2,"fulltext":"Recommendation: Reviewer's comments unavailable due to the journal's policy.\n"},{"type":"reviewerAgreed","content":"","date":"2020-11-04T01:00:00+00:00","index":2,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-11-04T01:00:00+00:00","index":3,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2020-11-04T00:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-11-04T00:00:00+00:00","index":1,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-11-04T00:00:00+00:00","index":3,"fulltext":"Recommendation: Reviewer's comments unavailable due to the journal's policy.\n"},{"type":"editorInvitedReview","content":"","date":"2020-11-04T00:00:00+00:00","index":1,"fulltext":"Recommendation: Reviewer's comments unavailable due to the journal's 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