Exploring the Role of Elevated Uric Acid in Acute Kidney Injury: A Comprehensive Review of Pathways and Therapeutic Approaches

Abstract Acute kidney injury caused by hyperuricemia is a serious disorder in which high serum uric acid levels damage the kidneys directly and indirectly. The purpose of this review is to clarify the role that hyperuricemia plays in acute kidney injury (AKI), encompassing both crystal-dependent and crystal-independent pathways. It covers the new insights of prerenal, intrinsic, and postrenal AKI pathways brought on by hyperuricemia. Finding pertinent studies by performing a thorough literature search across several databases, including PubMed, Scopus, Web of Science, and Google Scholar. After downloading the article, it was imported into Reference Manager and manually screened for duplicate references using the author names, journals, and publication dates (years) as a guide. Damaged tubular cells release damage-associated molecular patterns, which worsen kidney injury. Early identification and treatment of hyperuricemia are crucial to prevent permanent kidney damage or the onset of chronic renal disease.