Diagnostic Value of Serum miR-25-3p in Hypertensive Disorders in Pregnancy

Abstract Objective: Hypertensive disorders in pregnancy (HDIP) are a variety of heterogeneous conditions. microRNA (miR)-25-3p is involved in HDIP diagnosis. This study explored the clinical effects of miR-25-3p on HDIP patients.Methods: A total of 190 HDIP patients including 65 cases of gestation hypertension (GH), 67 cases of mild preeclampsia (mPE) and 58 cases of severe preeclampsia (sPEz), and 60 normal pregnant women were selected as the control. Serum miR-25-3p expression in HDIP patients and controls was detected. Diagnostic efficacy of miR-25-3p on HDIP was analyzed. HDIP patients were assigned into high/low miR-25-3p expression groups. sPEz patients assigned into high/low miR-25-3p expression group were followed up until delivery. Gestational weeks and pregnancy outcomes were recorded at delivery. The effect of miR-25-3p expression on pregnancy outcomes of sPE patients was analyzed.Results: Compared with the controls, miR-25-3p expression in GH, mPE and sPEz patients was upregulated. miR-25-3p expression was highest in sPE patients, then in mPE patients and then in GH patients. Area under the curve of miR-25-3p for sPEz diagnosis was 0.946, with 87.93% sensitivity and 98.33% specificity, which were higher than those for GH and mPE diagnosis. In sPEz patients, systolic and diastolic blood pressure, 24-h urine protein, AST, ALT, GGT and Scr were increased, and PLT was decreased in high expression group. High miR-25-3p expression increased risks of adverse pregnancy outcome in sPEz patients.Conclusions: High miR-25-3p expression helps HDIP diagnosis and is related to increased risks of adverse pregnancy outcomes in sPEz patients.