HPA-AXIS IN NTBI OVERLOAD

HPA-AXIS IN NTBI OVERLOAD | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 21 November 2025 V2 Latest version Share on HPA-AXIS IN NTBI OVERLOAD Authors : Marius Lazar , David Seideman , Lucas Smith , Sofia Makri , Benjamin Steinberg , Adrian Tudor , Tamara Dimitrikova , … Show All … , Olga Ivanova , Marianne Wagner , Alexander Louw , Margaret Pistorius , Riku Honda , Boris Cohen , Alexander Strelkov , Susan Tudor , Georg Schuster , and Dr. Carolina Diamandis 0000-0002-6142-4195 [email protected] Show Fewer Authors Info & Affiliations https://doi.org/10.22541/au.166733710.08669086/v2 421 views 191 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Since H63D syndrome was first described, the authors of this paper systematically investigated for the first time to what extent the adrenal glands, as an integral part of the HPA and SAM axes, are also affected by damage caused by non-transferrin bound iron (NTBI), a hallmark of H63D syndrome. Due to the rarity of the H63D syndrome, the representatives of a number of institutions that regularly deal with the topic in the context of their clinical and research activities have come together for this purpose. Thus, a small but significant amount of patient data could be collected worldwide, analyzed and evaluated, with surprisingly clear pathological results. A secondary aspect is that after reviewing the currently available literature, the team of authors came to the conclusion that the issue of HPA and SAM axes dysfunctions and adrenal synthesis activity seems to be also more frequent in other iron metabolic disorders than it is addressed to in everyday’s clinical practice. The result of this work is a warning call to closely monitor the catecholamine balance, the synthesis and control of all "stress hormones", the condition of the adrenal glands as well as other axis structures very early in the course of the H63D syndrome, in order to make unnecessary organ damages at least a little less likely, if not to prevent it to a large extent if detected early. In the meantime, this work has undergone peer review under the auspices of Swabian Research. In some instances, however, the repository in which it is deposited has not implemented this important change in status, and this note is therefore being provided for clarification. Supplementary Material File (h63d syndrome causing adrenal dysfunction iii.pdf) Download 695.21 KB Information & Authors Information Version history V1 Version 1 01 November 2022 V2 Version 2 21 November 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords adrenal glands adrenaline corticosteroid cortisol damage h63d mutation h63d syndrome hpa axis iron ntbi sam axis Authors Affiliations Marius Lazar View all articles by this author David Seideman View all articles by this author Lucas Smith View all articles by this author Sofia Makri View all articles by this author Benjamin Steinberg View all articles by this author Adrian Tudor View all articles by this author Tamara Dimitrikova View all articles by this author Olga Ivanova View all articles by this author Marianne Wagner View all articles by this author Alexander Louw View all articles by this author Margaret Pistorius View all articles by this author Riku Honda View all articles by this author Boris Cohen View all articles by this author Alexander Strelkov View all articles by this author Susan Tudor View all articles by this author Georg Schuster View all articles by this author Dr. Carolina Diamandis 0000-0002-6142-4195 [email protected] View all articles by this author Metrics & Citations Metrics Article Usage 421 views 191 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Marius Lazar, David Seideman, Lucas Smith, et al. HPA-AXIS IN NTBI OVERLOAD. Authorea . 21 November 2025. DOI: https://doi.org/10.22541/au.166733710.08669086/v2 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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