Fucoidan functionalized cerium oxide nanoparticles (Fu/CeO2NPs): A multidimensional investigation

Nanotechnology is an expanded branch of current research that involves the production and customization of particle structures with typical sizes of less than 100nm for various uses. A large area of surface to volume ratio was related with minimum surface functionalization, resulting in nanostructured metal oxide nanoparticles with outstanding biomedical characteristics. Cerium oxide (CeO 2 ) is the most approachable rare earth metal oxide due to its selective nature. In this first time reported that the nature of fucoidan functionalized Cerium oxide nanoparticles were determined by using UV-Vis, FE-SEM, HR-TEM, DLS, Zeta potential, FT-IR, XRD and XPS spectroscopic examination. The CeO 2 NPs and Fu/CeO 2 NPs have been effectively cause cell wall damage of pathogenic bacteria E.coli and S.aureus . In-vitro antioxidant activities were showed significant results were obtained CeO 2 NPs and Fu/CeO 2 NPs. Dose-dependent cytotoxicity assay of CeO 2 NPs and Fu/CeO 2 NPs have been treated against A549 (lung) and Hela (cervical) cancer cells. Furthermore, cell morphological changes have analysed by using fluorescent microscopic staining techniques like AO/EB, Hoechst and JC-1. Fu/CeO 2 NPs have more effectively degraded the carcinogenic dye Congo red under sunlight. The present investigation of CeO 2 NPs and Fu/CeO 2 NPs as a novel theranostic platform for bacterial/cancer treatment.