Evaluation by app in smartphones of awake... | F1000Research "use strict";function _typeof(t){return(_typeof="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(t){return typeof t}:function(t){return t&&"function"==typeof Symbol&&t.constructor===Symbol&&t!==Symbol.prototype?"symbol":typeof t})(t)}!function(){var t=function(){var t,e,o=[],n=window,r=n;for(;r;){try{if(r.frames.__tcfapiLocator){t=r;break}}catch(t){}if(r===n.top)break;r=r.parent}t||(!function t(){var e=n.document,o=!!n.frames.__tcfapiLocator;if(!o)if(e.body){var r=e.createElement("iframe");r.style.cssText="display:none",r.name="__tcfapiLocator",e.body.appendChild(r)}else setTimeout(t,5);return!o}(),n.__tcfapi=function(){for(var t=arguments.length,n=new Array(t),r=0;r 3&&2===parseInt(n[1],10)&&"boolean"==typeof n[3]&&(e=n[3],"function"==typeof n[2]&&n[2]("set",!0)):"ping"===n[0]?"function"==typeof n[2]&&n[2]({gdprApplies:e,cmpLoaded:!1,cmpStatus:"stub"}):o.push(n)},n.addEventListener("message",(function(t){var e="string"==typeof t.data,o={};if(e)try{o=JSON.parse(t.data)}catch(t){}else o=t.data;var n="object"===_typeof(o)&&null!==o?o.__tcfapiCall:null;n&&window.__tcfapi(n.command,n.version,(function(o,r){var a={__tcfapiReturn:{returnValue:o,success:r,callId:n.callId}};t&&t.source&&t.source.postMessage&&t.source.postMessage(e?JSON.stringify(a):a,"*")}),n.parameter)}),!1))};"undefined"!=typeof module?module.exports=t:t()}(); dataLayer = dataLayer || []; // Standard GTM initialization - Google Consent Mode handles consent automatically (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl+ '>m_auth=hzk0Vc3qFsQYhCrIoHz68A>m_preview=env-1>m_cookies_win=x';f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-MWFK8L5J'); ;window.NREUM||(NREUM={});NREUM.init={distributed_tracing:{enabled:true},privacy:{cookies_enabled:true},ajax:{deny_list:["bam.nr-data.net"]}}; ;NREUM.loader_config={accountID:"438030",trustKey:"438030",agentID:"772317073",licenseKey:"97f8f67f26",applicationID:"772317073"} ;NREUM.info={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net",licenseKey:"97f8f67f26",applicationID:"772317073",sa:1} ;/*! For license information please see nr-loader-spa-1.236.0.min.js.LICENSE.txt */ (()=>{"use strict";var e,t,r={5763:(e,t,r)=>{r.d(t,{P_:()=>l,Mt:()=>g,C5:()=>s,DL:()=>v,OP:()=>T,lF:()=>D,Yu:()=>y,Dg:()=>h,CX:()=>c,GE:()=>b,sU:()=>_});var n=r(8632),i=r(9567);const o={beacon:n.ce.beacon,errorBeacon:n.ce.errorBeacon,licenseKey:void 0,applicationID:void 0,sa:void 0,queueTime:void 0,applicationTime:void 0,ttGuid:void 0,user:void 0,account:void 0,product:void 0,extra:void 0,jsAttributes:{},userAttributes:void 0,atts:void 0,transactionName:void 0,tNamePlain:void 0},a={};function s(e){if(!e)throw new Error("All info objects require an agent identifier!");if(!a[e])throw new Error("Info for ".concat(e," was never set"));return a[e]}function c(e,t){if(!e)throw new Error("All info objects require an agent identifier!");a[e]=(0,i.D)(t,o),(0,n.Qy)(e,a[e],"info")}var u=r(7056);const d=()=>{const e={blockSelector:"[data-nr-block]",maskInputOptions:{password:!0}};return{allow_bfcache:!0,privacy:{cookies_enabled:!0},ajax:{deny_list:void 0,enabled:!0,harvestTimeSeconds:10},distributed_tracing:{enabled:void 0,exclude_newrelic_header:void 0,cors_use_newrelic_header:void 0,cors_use_tracecontext_headers:void 0,allowed_origins:void 0},session:{domain:void 0,expiresMs:u.oD,inactiveMs:u.Hb},ssl:void 0,obfuscate:void 0,jserrors:{enabled:!0,harvestTimeSeconds:10},metrics:{enabled:!0},page_action:{enabled:!0,harvestTimeSeconds:30},page_view_event:{enabled:!0},page_view_timing:{enabled:!0,harvestTimeSeconds:30,long_task:!1},session_trace:{enabled:!0,harvestTimeSeconds:10},harvest:{tooManyRequestsDelay:60},session_replay:{enabled:!1,harvestTimeSeconds:60,sampleRate:.1,errorSampleRate:.1,maskTextSelector:"*",maskAllInputs:!0,get blockClass(){return"nr-block"},get ignoreClass(){return"nr-ignore"},get maskTextClass(){return"nr-mask"},get blockSelector(){return e.blockSelector},set blockSelector(t){e.blockSelector+=",".concat(t)},get maskInputOptions(){return e.maskInputOptions},set maskInputOptions(t){e.maskInputOptions={...t,password:!0}}},spa:{enabled:!0,harvestTimeSeconds:10}}},f={};function l(e){if(!e)throw new Error("All configuration objects require an agent identifier!");if(!f[e])throw new Error("Configuration for ".concat(e," was never set"));return f[e]}function h(e,t){if(!e)throw new Error("All configuration objects require an agent identifier!");f[e]=(0,i.D)(t,d()),(0,n.Qy)(e,f[e],"config")}function g(e,t){if(!e)throw new Error("All configuration objects require an agent identifier!");var r=l(e);if(r){for(var n=t.split("."),i=0;i {r.d(t,{D:()=>i});var n=r(50);function i(e,t){try{if(!e||"object"!=typeof e)return(0,n.Z)("Setting a Configurable requires an object as input");if(!t||"object"!=typeof t)return(0,n.Z)("Setting a Configurable requires a model to set its initial properties");const r=Object.create(Object.getPrototypeOf(t),Object.getOwnPropertyDescriptors(t)),o=0===Object.keys(r).length?e:r;for(let a in o)if(void 0!==e[a])try{"object"==typeof e[a]&&"object"==typeof t[a]?r[a]=i(e[a],t[a]):r[a]=e[a]}catch(e){(0,n.Z)("An error occurred while setting a property of a Configurable",e)}return r}catch(e){(0,n.Z)("An error occured while setting a Configurable",e)}}},6818:(e,t,r)=>{r.d(t,{Re:()=>i,gF:()=>o,q4:()=>n});const n="1.236.0",i="PROD",o="CDN"},385:(e,t,r)=>{r.d(t,{FN:()=>a,IF:()=>u,Nk:()=>f,Tt:()=>s,_A:()=>o,il:()=>n,pL:()=>c,v6:()=>i,w1:()=>d});const n="undefined"!=typeof window&&!!window.document,i="undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self.navigator instanceof WorkerNavigator||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis.navigator instanceof WorkerNavigator),o=n?window:"undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis),a=""+o?.location,s=/iPad|iPhone|iPod/.test(navigator.userAgent),c=s&&"undefined"==typeof SharedWorker,u=(()=>{const e=navigator.userAgent.match(/Firefox[/\s](\d+\.\d+)/);return Array.isArray(e)&&e.length>=2?+e[1]:0})(),d=Boolean(n&&window.document.documentMode),f=!!navigator.sendBeacon},1117:(e,t,r)=>{r.d(t,{w:()=>o});var n=r(50);const i={agentIdentifier:"",ee:void 0};class o{constructor(e){try{if("object"!=typeof e)return(0,n.Z)("shared context requires an object as input");this.sharedContext={},Object.assign(this.sharedContext,i),Object.entries(e).forEach((e=>{let[t,r]=e;Object.keys(i).includes(t)&&(this.sharedContext[t]=r)}))}catch(e){(0,n.Z)("An error occured while setting SharedContext",e)}}}},8e3:(e,t,r)=>{r.d(t,{L:()=>d,R:()=>c});var n=r(2177),i=r(1284),o=r(4322),a=r(3325);const s={};function c(e,t){const r={staged:!1,priority:a.p[t]||0};u(e),s[e].get(t)||s[e].set(t,r)}function u(e){e&&(s[e]||(s[e]=new Map))}function d(){let e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:"",t=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"feature";if(u(e),!e||!s[e].get(t))return a(t);s[e].get(t).staged=!0;const r=[...s[e]];function a(t){const r=e?n.ee.get(e):n.ee,a=o.X.handlers;if(r.backlog&&a){var s=r.backlog[t],c=a[t];if(c){for(var u=0;s&&u {let[t,r]=e;return r.staged}))&&(r.sort(((e,t)=>e[1].priority-t[1].priority)),r.forEach((e=>{let[t]=e;a(t)})))}function f(e,t){var r=e[1];(0,i.D)(t[r],(function(t,r){var n=e[0];if(r[0]===n){var i=r[1],o=e[3],a=e[2];i.apply(o,a)}}))}},2177:(e,t,r)=>{r.d(t,{c:()=>f,ee:()=>u});var n=r(8632),i=r(2210),o=r(1284),a=r(5763),s="nr@context";let c=(0,n.fP)();var u;function d(){}function f(e){return(0,i.X)(e,s,l)}function l(){return new d}function h(){u.aborted=!0,u.backlog={}}c.ee?u=c.ee:(u=function e(t,r){var n={},c={},f={},g=!1;try{g=16===r.length&&(0,a.OP)(r).isolatedBacklog}catch(e){}var p={on:b,addEventListener:b,removeEventListener:y,emit:v,get:x,listeners:w,context:m,buffer:A,abort:h,aborted:!1,isBuffering:E,debugId:r,backlog:g?{}:t&&"object"==typeof t.backlog?t.backlog:{}};return p;function m(e){return e&&e instanceof d?e:e?(0,i.X)(e,s,l):l()}function v(e,r,n,i,o){if(!1!==o&&(o=!0),!u.aborted||i){t&&o&&t.emit(e,r,n);for(var a=m(n),s=w(e),d=s.length,f=0;fn,p:()=>i});var n=r(2177).ee.get("handle");function i(e,t,r,i,o){o?(o.buffer([e],i),o.emit(e,t,r)):(n.buffer([e],i),n.emit(e,t,r))}},4322:(e,t,r)=>{r.d(t,{X:()=>o});var n=r(5546);o.on=a;var i=o.handlers={};function o(e,t,r,o){a(o||n.E,i,e,t,r)}function a(e,t,r,i,o){o||(o="feature"),e||(e=n.E);var a=t[o]=t[o]||{};(a[r]=a[r]||[]).push([e,i])}},3239:(e,t,r)=>{r.d(t,{bP:()=>s,iz:()=>c,m$:()=>a});var n=r(385);let i=!1,o=!1;try{const e={get passive(){return i=!0,!1},get signal(){return o=!0,!1}};n._A.addEventListener("test",null,e),n._A.removeEventListener("test",null,e)}catch(e){}function a(e,t){return i||o?{capture:!!e,passive:i,signal:t}:!!e}function s(e,t){let r=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3?arguments[3]:void 0;window.addEventListener(e,t,a(r,n))}function c(e,t){let r=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3?arguments[3]:void 0;document.addEventListener(e,t,a(r,n))}},4402:(e,t,r)=>{r.d(t,{Ht:()=>u,M:()=>c,Rl:()=>a,ky:()=>s});var n=r(385);const i="xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx";function o(e,t){return e?15&e[t]:16*Math.random()|0}function a(){const e=n._A?.crypto||n._A?.msCrypto;let t,r=0;return e&&e.getRandomValues&&(t=e.getRandomValues(new Uint8Array(31))),i.split("").map((e=>"x"===e?o(t,++r).toString(16):"y"===e?(3&o()|8).toString(16):e)).join("")}function s(e){const t=n._A?.crypto||n._A?.msCrypto;let r,i=0;t&&t.getRandomValues&&(r=t.getRandomValues(new Uint8Array(31)));const a=[];for(var s=0;s {r.d(t,{Bq:()=>n,Hb:()=>o,oD:()=>i});const n="NRBA",i=144e5,o=18e5},7894:(e,t,r)=>{function n(){return Math.round(performance.now())}r.d(t,{z:()=>n})},7243:(e,t,r)=>{r.d(t,{e:()=>o});var n=r(385),i={};function o(e){if(e in i)return i[e];if(0===(e||"").indexOf("data:"))return{protocol:"data"};let t;var r=n._A?.location,o={};if(n.il)t=document.createElement("a"),t.href=e;else try{t=new URL(e,r.href)}catch(e){return o}o.port=t.port;var a=t.href.split("://");!o.port&&a[1]&&(o.port=a[1].split("/")[0].split("@").pop().split(":")[1]),o.port&&"0"!==o.port||(o.port="https"===a[0]?"443":"80"),o.hostname=t.hostname||r.hostname,o.pathname=t.pathname,o.protocol=a[0],"/"!==o.pathname.charAt(0)&&(o.pathname="/"+o.pathname);var s=!t.protocol||":"===t.protocol||t.protocol===r.protocol,c=t.hostname===r.hostname&&t.port===r.port;return o.sameOrigin=s&&(!t.hostname||c),"/"===o.pathname&&(i[e]=o),o}},50:(e,t,r)=>{function n(e,t){"function"==typeof console.warn&&(console.warn("New Relic: ".concat(e)),t&&console.warn(t))}r.d(t,{Z:()=>n})},2587:(e,t,r)=>{r.d(t,{N:()=>c,T:()=>u});var n=r(2177),i=r(5546),o=r(8e3),a=r(3325);const s={stn:[a.D.sessionTrace],err:[a.D.jserrors,a.D.metrics],ins:[a.D.pageAction],spa:[a.D.spa],sr:[a.D.sessionReplay,a.D.sessionTrace]};function c(e,t){const r=n.ee.get(t);e&&"object"==typeof e&&(Object.entries(e).forEach((e=>{let[t,n]=e;void 0===u[t]&&(s[t]?s[t].forEach((e=>{n?(0,i.p)("feat-"+t,[],void 0,e,r):(0,i.p)("block-"+t,[],void 0,e,r),(0,i.p)("rumresp-"+t,[Boolean(n)],void 0,e,r)})):n&&(0,i.p)("feat-"+t,[],void 0,void 0,r),u[t]=Boolean(n))})),Object.keys(s).forEach((e=>{void 0===u[e]&&(s[e]?.forEach((t=>(0,i.p)("rumresp-"+e,[!1],void 0,t,r))),u[e]=!1)})),(0,o.L)(t,a.D.pageViewEvent))}const u={}},2210:(e,t,r)=>{r.d(t,{X:()=>i});var n=Object.prototype.hasOwnProperty;function i(e,t,r){if(n.call(e,t))return e[t];var i=r();if(Object.defineProperty&&Object.keys)try{return Object.defineProperty(e,t,{value:i,writable:!0,enumerable:!1}),i}catch(e){}return e[t]=i,i}},1284:(e,t,r)=>{r.d(t,{D:()=>n});const n=(e,t)=>Object.entries(e||{}).map((e=>{let[r,n]=e;return t(r,n)}))},4351:(e,t,r)=>{r.d(t,{P:()=>o});var n=r(2177);const i=()=>{const e=new WeakSet;return(t,r)=>{if("object"==typeof r&&null!==r){if(e.has(r))return;e.add(r)}return r}};function o(e){try{return JSON.stringify(e,i())}catch(e){try{n.ee.emit("internal-error",[e])}catch(e){}}}},3960:(e,t,r)=>{r.d(t,{K:()=>a,b:()=>o});var n=r(3239);function i(){return"undefined"==typeof document||"complete"===document.readyState}function o(e,t){if(i())return e();(0,n.bP)("load",e,t)}function a(e){if(i())return e();(0,n.iz)("DOMContentLoaded",e)}},8632:(e,t,r)=>{r.d(t,{EZ:()=>u,Qy:()=>c,ce:()=>o,fP:()=>a,gG:()=>d,mF:()=>s});var n=r(7894),i=r(385);const o={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net"};function a(){return i._A.NREUM||(i._A.NREUM={}),void 0===i._A.newrelic&&(i._A.newrelic=i._A.NREUM),i._A.NREUM}function s(){let e=a();return e.o||(e.o={ST:i._A.setTimeout,SI:i._A.setImmediate,CT:i._A.clearTimeout,XHR:i._A.XMLHttpRequest,REQ:i._A.Request,EV:i._A.Event,PR:i._A.Promise,MO:i._A.MutationObserver,FETCH:i._A.fetch}),e}function c(e,t,r){let i=a();const o=i.initializedAgents||{},s=o[e]||{};return Object.keys(s).length||(s.initializedAt={ms:(0,n.z)(),date:new Date}),i.initializedAgents={...o,[e]:{...s,[r]:t}},i}function u(e,t){a()[e]=t}function d(){return function(){let e=a();const t=e.info||{};e.info={beacon:o.beacon,errorBeacon:o.errorBeacon,...t}}(),function(){let e=a();const t=e.init||{};e.init={...t}}(),s(),function(){let e=a();const t=e.loader_config||{};e.loader_config={...t}}(),a()}},7956:(e,t,r)=>{r.d(t,{N:()=>i});var n=r(3239);function i(e){let t=arguments.length>1&&void 0!==arguments[1]&&arguments[1],r=arguments.length>2?arguments[2]:void 0,i=arguments.length>3?arguments[3]:void 0;return void(0,n.iz)("visibilitychange",(function(){if(t)return void("hidden"==document.visibilityState&&e());e(document.visibilityState)}),r,i)}},1214:(e,t,r)=>{r.d(t,{em:()=>v,u5:()=>N,QU:()=>S,_L:()=>I,Gm:()=>L,Lg:()=>M,gy:()=>U,BV:()=>Q,Kf:()=>ee});var n=r(2177);const i="nr@original";var o=Object.prototype.hasOwnProperty,a=!1;function s(e,t){return e||(e=n.ee),r.inPlace=function(e,t,n,i,o){n||(n="");var a,s,c,u="-"===n.charAt(0);for(c=0;c 2?n-2:0),o=2;o {r(A[T],e,w),r(E[T],e,w)})),r(l._A,"fetch",y),t.on(y+"end",(function(e,r){var n=this;if(r){var i=r.headers.get("content-length");null!==i&&(n.rxSize=i),t.emit(y+"done",[null,r],n)}else t.emit(y+"done",[e],n)})),t}const O={},j=["pushState","replaceState"];function S(e){const t=function(e){return(e||n.ee).get("history")}(e);return!l.il||O[t.debugId]++||(O[t.debugId]=1,s(t).inPlace(window.history,j,"-")),t}var P=r(3239);const C={},R=["appendChild","insertBefore","replaceChild"];function I(e){const t=function(e){return(e||n.ee).get("jsonp")}(e);if(!l.il||C[t.debugId])return t;C[t.debugId]=!0;var r=s(t),i=/[?&](?:callback|cb)=([^&#]+)/,o=/(.*)\.([^.]+)/,a=/^(\w+)(\.|$)(.*)$/;function c(e,t){var r=e.match(a),n=r[1],i=r[3];return i?c(i,t[n]):t[n]}return r.inPlace(Node.prototype,R,"dom-"),t.on("dom-start",(function(e){!function(e){if(!e||"string"!=typeof e.nodeName||"script"!==e.nodeName.toLowerCase())return;if("function"!=typeof e.addEventListener)return;var n=(a=e.src,s=a.match(i),s?s[1]:null);var a,s;if(!n)return;var u=function(e){var t=e.match(o);if(t&&t.length>=3)return{key:t[2],parent:c(t[1],window)};return{key:e,parent:window}}(n);if("function"!=typeof u.parent[u.key])return;var d={};function f(){t.emit("jsonp-end",[],d),e.removeEventListener("load",f,(0,P.m$)(!1)),e.removeEventListener("error",l,(0,P.m$)(!1))}function l(){t.emit("jsonp-error",[],d),t.emit("jsonp-end",[],d),e.removeEventListener("load",f,(0,P.m$)(!1)),e.removeEventListener("error",l,(0,P.m$)(!1))}r.inPlace(u.parent,[u.key],"cb-",d),e.addEventListener("load",f,(0,P.m$)(!1)),e.addEventListener("error",l,(0,P.m$)(!1)),t.emit("new-jsonp",[e.src],d)}(e[0])})),t}var k=r(5763);const H={};function L(e){const t=function(e){return(e||n.ee).get("mutation")}(e);if(!l.il||H[t.debugId])return t;H[t.debugId]=!0;var r=s(t),i=k.Yu.MO;return i&&(window.MutationObserver=function(e){return this instanceof i?new i(r(e,"fn-")):i.apply(this,arguments)},MutationObserver.prototype=i.prototype),t}const z={};function M(e){const t=function(e){return(e||n.ee).get("promise")}(e);if(z[t.debugId])return t;z[t.debugId]=!0;var r=n.c,o=s(t),a=k.Yu.PR;return a&&function(){function e(r){var n=t.context(),i=o(r,"executor-",n,null,!1);const s=Reflect.construct(a,[i],e);return t.context(s).getCtx=function(){return n},s}l._A.Promise=e,Object.defineProperty(e,"name",{value:"Promise"}),e.toString=function(){return a.toString()},Object.setPrototypeOf(e,a),["all","race"].forEach((function(r){const n=a[r];e[r]=function(e){let i=!1;[...e||[]].forEach((e=>{this.resolve(e).then(a("all"===r),a(!1))}));const o=n.apply(this,arguments);return o;function a(e){return function(){t.emit("propagate",[null,!i],o,!1,!1),i=i||!e}}}})),["resolve","reject"].forEach((function(r){const n=a[r];e[r]=function(e){const r=n.apply(this,arguments);return e!==r&&t.emit("propagate",[e,!0],r,!1,!1),r}})),e.prototype=a.prototype;const n=a.prototype.then;a.prototype.then=function(){var e=this,i=r(e);i.promise=e;for(var a=arguments.length,s=new Array(a),c=0;c e())),t};function m(e,t){i.inPlace(t,["onreadystatechange"],"fn-",E)}function b(){var e=this,t=r.context(e);e.readyState>3&&!t.resolved&&(t.resolved=!0,r.emit("xhr-resolved",[],e)),i.inPlace(e,f,"fn-",E)}if(function(e,t){for(var r in e)t[r]=e[r]}(o,p),p.prototype=o.prototype,i.inPlace(p.prototype,J,"-xhr-",E),r.on("send-xhr-start",(function(e,t){m(e,t),function(e){h.push(e),a&&(y?y.then(A):u?u(A):(w=-w,x.data=w))}(t)})),r.on("open-xhr-start",m),a){var y=c&&c.resolve();if(!u&&!c){var w=1,x=document.createTextNode(w);new a(A).observe(x,{characterData:!0})}}else t.on("fn-end",(function(e){e[0]&&e[0].type===d||A()}));function A(){for(var e=0;e {r.d(t,{t:()=>n});const n=r(3325).D.ajax},6660:(e,t,r)=>{r.d(t,{A:()=>i,t:()=>n});const n=r(3325).D.jserrors,i="nr@seenError"},3081:(e,t,r)=>{r.d(t,{gF:()=>o,mY:()=>i,t9:()=>n,vz:()=>s,xS:()=>a});const n=r(3325).D.metrics,i="sm",o="cm",a="storeSupportabilityMetrics",s="storeEventMetrics"},4649:(e,t,r)=>{r.d(t,{t:()=>n});const n=r(3325).D.pageAction},7633:(e,t,r)=>{r.d(t,{Dz:()=>i,OJ:()=>a,qw:()=>o,t9:()=>n});const n=r(3325).D.pageViewEvent,i="firstbyte",o="domcontent",a="windowload"},9251:(e,t,r)=>{r.d(t,{t:()=>n});const n=r(3325).D.pageViewTiming},3614:(e,t,r)=>{r.d(t,{BST_RESOURCE:()=>i,END:()=>s,FEATURE_NAME:()=>n,FN_END:()=>u,FN_START:()=>c,PUSH_STATE:()=>d,RESOURCE:()=>o,START:()=>a});const n=r(3325).D.sessionTrace,i="bstResource",o="resource",a="-start",s="-end",c="fn"+a,u="fn"+s,d="pushState"},7836:(e,t,r)=>{r.d(t,{BODY:()=>A,CB_END:()=>E,CB_START:()=>u,END:()=>x,FEATURE_NAME:()=>i,FETCH:()=>_,FETCH_BODY:()=>v,FETCH_DONE:()=>m,FETCH_START:()=>p,FN_END:()=>c,FN_START:()=>s,INTERACTION:()=>l,INTERACTION_API:()=>d,INTERACTION_EVENTS:()=>o,JSONP_END:()=>b,JSONP_NODE:()=>g,JS_TIME:()=>T,MAX_TIMER_BUDGET:()=>a,REMAINING:()=>f,SPA_NODE:()=>h,START:()=>w,originalSetTimeout:()=>y});var n=r(5763);const i=r(3325).D.spa,o=["click","submit","keypress","keydown","keyup","change"],a=999,s="fn-start",c="fn-end",u="cb-start",d="api-ixn-",f="remaining",l="interaction",h="spaNode",g="jsonpNode",p="fetch-start",m="fetch-done",v="fetch-body-",b="jsonp-end",y=n.Yu.ST,w="-start",x="-end",A="-body",E="cb"+x,T="jsTime",_="fetch"},5938:(e,t,r)=>{r.d(t,{W:()=>o});var n=r(5763),i=r(2177);class o{constructor(e,t,r){this.agentIdentifier=e,this.aggregator=t,this.ee=i.ee.get(e,(0,n.OP)(this.agentIdentifier).isolatedBacklog),this.featureName=r,this.blocked=!1}}},9144:(e,t,r)=>{r.d(t,{j:()=>m});var n=r(3325),i=r(5763),o=r(5546),a=r(2177),s=r(7894),c=r(8e3),u=r(3960),d=r(385),f=r(50),l=r(3081),h=r(8632);function g(){const e=(0,h.gG)();["setErrorHandler","finished","addToTrace","inlineHit","addRelease","addPageAction","setCurrentRouteName","setPageViewName","setCustomAttribute","interaction","noticeError","setUserId"].forEach((t=>{e[t]=function(){for(var r=arguments.length,n=new Array(r),i=0;i 1?r-1:0),i=1;i {e.exposed&&e.api[t]&&o.push(e.api[t](...n))})),o.length>1?o:o[0]}(t,...n)}}))}var p=r(2587);function m(e){let t=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{},m=arguments.length>2?arguments[2]:void 0,v=arguments.length>3?arguments[3]:void 0,{init:b,info:y,loader_config:w,runtime:x={loaderType:m},exposed:A=!0}=t;const E=(0,h.gG)();y||(b=E.init,y=E.info,w=E.loader_config),(0,i.Dg)(e,b||{}),(0,i.GE)(e,w||{}),(0,i.sU)(e,x),y.jsAttributes??={},d.v6&&(y.jsAttributes.isWorker=!0),(0,i.CX)(e,y),g();const T=function(e,t){t||(0,c.R)(e,"api");const h={};var g=a.ee.get(e),p=g.get("tracer"),m="api-",v=m+"ixn-";function b(t,r,n,o){const a=(0,i.C5)(e);return null===r?delete a.jsAttributes[t]:(0,i.CX)(e,{...a,jsAttributes:{...a.jsAttributes,[t]:r}}),x(m,n,!0,o||null===r?"session":void 0)(t,r)}function y(){}["setErrorHandler","finished","addToTrace","inlineHit","addRelease"].forEach((e=>h[e]=x(m,e,!0,"api"))),h.addPageAction=x(m,"addPageAction",!0,n.D.pageAction),h.setCurrentRouteName=x(m,"routeName",!0,n.D.spa),h.setPageViewName=function(t,r){if("string"==typeof t)return"/"!==t.charAt(0)&&(t="/"+t),(0,i.OP)(e).customTransaction=(r||"http://custom.transaction")+t,x(m,"setPageViewName",!0)()},h.setCustomAttribute=function(e,t){let r=arguments.length>2&&void 0!==arguments[2]&&arguments[2];if("string"==typeof e){if(["string","number"].includes(typeof t)||null===t)return b(e,t,"setCustomAttribute",r);(0,f.Z)("Failed to execute setCustomAttribute.\nNon-null value must be a string or number type, but a type of was provided."))}else(0,f.Z)("Failed to execute setCustomAttribute.\nName must be a string type, but a type of was provided."))},h.setUserId=function(e){if("string"==typeof e||null===e)return b("enduser.id",e,"setUserId",!0);(0,f.Z)("Failed to execute setUserId.\nNon-null value must be a string type, but a type of was provided."))},h.interaction=function(){return(new y).get()};var w=y.prototype={createTracer:function(e,t){var r={},i=this,a="function"==typeof t;return(0,o.p)(v+"tracer",[(0,s.z)(),e,r],i,n.D.spa,g),function(){if(p.emit((a?"":"no-")+"fn-start",[(0,s.z)(),i,a],r),a)try{return t.apply(this,arguments)}catch(e){throw p.emit("fn-err",[arguments,this,"string"==typeof e?new Error(e):e],r),e}finally{p.emit("fn-end",[(0,s.z)()],r)}}}};function x(e,t,r,i){return function(){return(0,o.p)(l.xS,["API/"+t+"/called"],void 0,n.D.metrics,g),i&&(0,o.p)(e+t,[(0,s.z)(),...arguments],r?null:this,i,g),r?void 0:this}}function A(){r.e(439).then(r.bind(r,7438)).then((t=>{let{setAPI:r}=t;r(e),(0,c.L)(e,"api")})).catch((()=>(0,f.Z)("Downloading runtime APIs failed...")))}return["actionText","setName","setAttribute","save","ignore","onEnd","getContext","end","get"].forEach((e=>{w[e]=x(v,e,void 0,n.D.spa)})),h.noticeError=function(e,t){"string"==typeof e&&(e=new Error(e)),(0,o.p)(l.xS,["API/noticeError/called"],void 0,n.D.metrics,g),(0,o.p)("err",[e,(0,s.z)(),!1,t],void 0,n.D.jserrors,g)},d.il?(0,u.b)((()=>A()),!0):A(),h}(e,v);return(0,h.Qy)(e,T,"api"),(0,h.Qy)(e,A,"exposed"),(0,h.EZ)("activatedFeatures",p.T),T}},3325:(e,t,r)=>{r.d(t,{D:()=>n,p:()=>i});const n={ajax:"ajax",jserrors:"jserrors",metrics:"metrics",pageAction:"page_action",pageViewEvent:"page_view_event",pageViewTiming:"page_view_timing",sessionReplay:"session_replay",sessionTrace:"session_trace",spa:"spa"},i={[n.pageViewEvent]:1,[n.pageViewTiming]:2,[n.metrics]:3,[n.jserrors]:4,[n.ajax]:5,[n.sessionTrace]:6,[n.pageAction]:7,[n.spa]:8,[n.sessionReplay]:9}}},n={};function i(e){var t=n[e];if(void 0!==t)return t.exports;var o=n[e]={exports:{}};return r[e](o,o.exports,i),o.exports}i.m=r,i.d=(e,t)=>{for(var r in t)i.o(t,r)&&!i.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},i.f={},i.e=e=>Promise.all(Object.keys(i.f).reduce(((t,r)=>(i.f[r](e,t),t)),[])),i.u=e=>(({78:"page_action-aggregate",147:"metrics-aggregate",242:"session-manager",317:"jserrors-aggregate",348:"page_view_timing-aggregate",412:"lazy-feature-loader",439:"async-api",538:"recorder",590:"session_replay-aggregate",675:"compressor",733:"session_trace-aggregate",786:"page_view_event-aggregate",873:"spa-aggregate",898:"ajax-aggregate"}[e]||e)+"."+{78:"ac76d497",147:"3dc53903",148:"1a20d5fe",242:"2a64278a",317:"49e41428",348:"bd6de33a",412:"2f55ce66",439:"30bd804e",538:"1b18459f",590:"cf0efb30",675:"ae9f91a8",733:"83105561",786:"06482edd",860:"03a8b7a5",873:"e6b09d52",898:"998ef92b"}[e]+"-1.236.0.min.js"),i.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),e={},t="NRBA:",i.l=(r,n,o,a)=>{if(e[r])e[r].push(n);else{var s,c;if(void 0!==o)for(var u=document.getElementsByTagName("script"),d=0;d {s.onerror=s.onload=null,clearTimeout(h);var i=e[r];if(delete e[r],s.parentNode&&s.parentNode.removeChild(s),i&&i.forEach((e=>e(n))),t)return t(n)},h=setTimeout(l.bind(null,void 0,{type:"timeout",target:s}),12e4);s.onerror=l.bind(null,s.onerror),s.onload=l.bind(null,s.onload),c&&document.head.appendChild(s)}},i.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},i.j=364,i.p="https://js-agent.newrelic.com/",(()=>{var e={364:0,953:0};i.f.j=(t,r)=>{var n=i.o(e,t)?e[t]:void 0;if(0!==n)if(n)r.push(n[2]);else{var o=new Promise(((r,i)=>n=e[t]=[r,i]));r.push(n[2]=o);var a=i.p+i.u(t),s=new Error;i.l(a,(r=>{if(i.o(e,t)&&(0!==(n=e[t])&&(e[t]=void 0),n)){var o=r&&("load"===r.type?"missing":r.type),a=r&&r.target&&r.target.src;s.message="Loading chunk "+t+" failed.\n("+o+": "+a+")",s.name="ChunkLoadError",s.type=o,s.request=a,n[1](s)}}),"chunk-"+t,t)}};var t=(t,r)=>{var n,o,[a,s,c]=r,u=0;if(a.some((t=>0!==e[t]))){for(n in s)i.o(s,n)&&(i.m[n]=s[n]);if(c)c(i)}for(t&&t(r);u {i.r(o);var e=i(3325),t=i(5763);const r=Object.values(e.D);function n(e){const n={};return r.forEach((r=>{n[r]=function(e,r){return!1!==(0,t.Mt)(r,"".concat(e,".enabled"))}(r,e)})),n}var a=i(9144);var s=i(5546),c=i(385),u=i(8e3),d=i(5938),f=i(3960),l=i(50);class h extends d.W{constructor(e,t,r){let n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3];super(e,t,r),this.auto=n,this.abortHandler,this.featAggregate,this.onAggregateImported,n&&(0,u.R)(e,r)}importAggregator(){let e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};if(this.featAggregate||!this.auto)return;const r=c.il&&!0===(0,t.Mt)(this.agentIdentifier,"privacy.cookies_enabled");let n;this.onAggregateImported=new Promise((e=>{n=e}));const o=async()=>{let t;try{if(r){const{setupAgentSession:e}=await Promise.all([i.e(860),i.e(242)]).then(i.bind(i,3228));t=e(this.agentIdentifier)}}catch(e){(0,l.Z)("A problem occurred when starting up session manager. This page will not start or extend any session.",e)}try{if(!this.shouldImportAgg(this.featureName,t))return void(0,u.L)(this.agentIdentifier,this.featureName);const{lazyFeatureLoader:r}=await i.e(412).then(i.bind(i,8582)),{Aggregate:o}=await r(this.featureName,"aggregate");this.featAggregate=new o(this.agentIdentifier,this.aggregator,e),n(!0)}catch(e){(0,l.Z)("Downloading and initializing ".concat(this.featureName," failed..."),e),this.abortHandler?.(),n(!1)}};c.il?(0,f.b)((()=>o()),!0):o()}shouldImportAgg(r,n){return r!==e.D.sessionReplay||!1!==(0,t.Mt)(this.agentIdentifier,"session_trace.enabled")&&(!!n?.isNew||!!n?.state.sessionReplay)}}var g=i(7633),p=i(7894);class m extends h{static featureName=g.t9;constructor(r,n){let i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(super(r,n,g.t9,i),("undefined"==typeof PerformanceNavigationTiming||c.Tt)&&"undefined"!=typeof PerformanceTiming){const n=(0,t.OP)(r);n[g.Dz]=Math.max(Date.now()-n.offset,0),(0,f.K)((()=>n[g.qw]=Math.max((0,p.z)()-n[g.Dz],0))),(0,f.b)((()=>{const t=(0,p.z)();n[g.OJ]=Math.max(t-n[g.Dz],0),(0,s.p)("timing",["load",t],void 0,e.D.pageViewTiming,this.ee)}))}this.importAggregator()}}var v=i(1117),b=i(1284);class y extends v.w{constructor(e){super(e),this.aggregatedData={}}store(e,t,r,n,i){var o=this.getBucket(e,t,r,i);return o.metrics=function(e,t){t||(t={count:0});return t.count+=1,(0,b.D)(e,(function(e,r){t[e]=w(r,t[e])})),t}(n,o.metrics),o}merge(e,t,r,n,i){var o=this.getBucket(e,t,n,i);if(o.metrics){var a=o.metrics;a.count+=r.count,(0,b.D)(r,(function(e,t){if("count"!==e){var n=a[e],i=r[e];i&&!i.c?a[e]=w(i.t,n):a[e]=function(e,t){if(!t)return e;t.c||(t=x(t.t));return t.min=Math.min(e.min,t.min),t.max=Math.max(e.max,t.max),t.t+=e.t,t.sos+=e.sos,t.c+=e.c,t}(i,a[e])}}))}else o.metrics=r}storeMetric(e,t,r,n){var i=this.getBucket(e,t,r);return i.stats=w(n,i.stats),i}getBucket(e,t,r,n){this.aggregatedData[e]||(this.aggregatedData[e]={});var i=this.aggregatedData[e][t];return i||(i=this.aggregatedData[e][t]={params:r||{}},n&&(i.custom=n)),i}get(e,t){return t?this.aggregatedData[e]&&this.aggregatedData[e][t]:this.aggregatedData[e]}take(e){for(var t={},r="",n=!1,i=0;i t.max&&(t.max=e),e 2&&void 0!==arguments[2])||arguments[2];super(e,r,j.t,n),c.il&&((0,t.OP)(e).initHidden=Boolean("hidden"===document.visibilityState),(0,N.N)((()=>(0,s.p)("docHidden",[(0,p.z)()],void 0,j.t,this.ee)),!0),(0,O.bP)("pagehide",(()=>(0,s.p)("winPagehide",[(0,p.z)()],void 0,j.t,this.ee))),this.importAggregator())}}var P=i(3081);class C extends h{static featureName=P.t9;constructor(e,t){let r=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];super(e,t,P.t9,r),this.importAggregator()}}var R,I=i(2210),k=i(1214),H=i(2177),L={};try{R=localStorage.getItem("__nr_flags").split(","),console&&"function"==typeof console.log&&(L.console=!0,-1!==R.indexOf("dev")&&(L.dev=!0),-1!==R.indexOf("nr_dev")&&(L.nrDev=!0))}catch(e){}function z(e){try{L.console&&z(e)}catch(e){}}L.nrDev&&H.ee.on("internal-error",(function(e){z(e.stack)})),L.dev&&H.ee.on("fn-err",(function(e,t,r){z(r.stack)})),L.dev&&(z("NR AGENT IN DEVELOPMENT MODE"),z("flags: "+(0,b.D)(L,(function(e,t){return e})).join(", ")));var M=i(6660);class B extends h{static featureName=M.t;constructor(r,n){let i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];super(r,n,M.t,i),this.skipNext=0;try{this.removeOnAbort=new AbortController}catch(e){}const o=this;o.ee.on("fn-start",(function(e,t,r){o.abortHandler&&(o.skipNext+=1)})),o.ee.on("fn-err",(function(t,r,n){o.abortHandler&&!n[M.A]&&((0,I.X)(n,M.A,(function(){return!0})),this.thrown=!0,(0,s.p)("err",[n,(0,p.z)()],void 0,e.D.jserrors,o.ee))})),o.ee.on("fn-end",(function(){o.abortHandler&&!this.thrown&&o.skipNext>0&&(o.skipNext-=1)})),o.ee.on("internal-error",(function(t){(0,s.p)("ierr",[t,(0,p.z)(),!0],void 0,e.D.jserrors,o.ee)})),this.origOnerror=c._A.onerror,c._A.onerror=this.onerrorHandler.bind(this),c._A.addEventListener("unhandledrejection",(t=>{const r=function(e){let t="Unhandled Promise Rejection: ";if(e instanceof Error)try{return e.message=t+e.message,e}catch(t){return e}if(void 0===e)return new Error(t);try{return new Error(t+(0,D.P)(e))}catch(e){return new Error(t)}}(t.reason);(0,s.p)("err",[r,(0,p.z)(),!1,{unhandledPromiseRejection:1}],void 0,e.D.jserrors,this.ee)}),(0,O.m$)(!1,this.removeOnAbort?.signal)),(0,k.gy)(this.ee),(0,k.BV)(this.ee),(0,k.em)(this.ee),(0,t.OP)(r).xhrWrappable&&(0,k.Kf)(this.ee),this.abortHandler=this.#e,this.importAggregator()}#e(){this.removeOnAbort?.abort(),this.abortHandler=void 0}onerrorHandler(t,r,n,i,o){"function"==typeof this.origOnerror&&this.origOnerror(...arguments);try{this.skipNext?this.skipNext-=1:(0,s.p)("err",[o||new F(t,r,n),(0,p.z)()],void 0,e.D.jserrors,this.ee)}catch(t){try{(0,s.p)("ierr",[t,(0,p.z)(),!0],void 0,e.D.jserrors,this.ee)}catch(e){}}return!1}}function F(e,t,r){this.message=e||"Uncaught error with no additional information",this.sourceURL=t,this.line=r}let U=1;const q="nr@id";function G(e){const t=typeof e;return!e||"object"!==t&&"function"!==t?-1:e===c._A?0:(0,I.X)(e,q,(function(){return U++}))}function V(e){if("string"==typeof e&&e.length)return e.length;if("object"==typeof e){if("undefined"!=typeof ArrayBuffer&&e instanceof ArrayBuffer&&e.byteLength)return e.byteLength;if("undefined"!=typeof Blob&&e instanceof Blob&&e.size)return e.size;if(!("undefined"!=typeof FormData&&e instanceof FormData))try{return(0,D.P)(e).length}catch(e){return}}}var X=i(7243);class W{constructor(e){this.agentIdentifier=e,this.generateTracePayload=this.generateTracePayload.bind(this),this.shouldGenerateTrace=this.shouldGenerateTrace.bind(this)}generateTracePayload(e){if(!this.shouldGenerateTrace(e))return null;var r=(0,t.DL)(this.agentIdentifier);if(!r)return null;var n=(r.accountID||"").toString()||null,i=(r.agentID||"").toString()||null,o=(r.trustKey||"").toString()||null;if(!n||!i)return null;var a=(0,_.M)(),s=(0,_.Ht)(),c=Date.now(),u={spanId:a,traceId:s,timestamp:c};return(e.sameOrigin||this.isAllowedOrigin(e)&&this.useTraceContextHeadersForCors())&&(u.traceContextParentHeader=this.generateTraceContextParentHeader(a,s),u.traceContextStateHeader=this.generateTraceContextStateHeader(a,c,n,i,o)),(e.sameOrigin&&!this.excludeNewrelicHeader()||!e.sameOrigin&&this.isAllowedOrigin(e)&&this.useNewrelicHeaderForCors())&&(u.newrelicHeader=this.generateTraceHeader(a,s,c,n,i,o)),u}generateTraceContextParentHeader(e,t){return"00-"+t+"-"+e+"-01"}generateTraceContextStateHeader(e,t,r,n,i){return i+"@nr=0-1-"+r+"-"+n+"-"+e+"----"+t}generateTraceHeader(e,t,r,n,i,o){if(!("function"==typeof c._A?.btoa))return null;var a={v:[0,1],d:{ty:"Browser",ac:n,ap:i,id:e,tr:t,ti:r}};return o&&n!==o&&(a.d.tk=o),btoa((0,D.P)(a))}shouldGenerateTrace(e){return this.isDtEnabled()&&this.isAllowedOrigin(e)}isAllowedOrigin(e){var r=!1,n={};if((0,t.Mt)(this.agentIdentifier,"distributed_tracing")&&(n=(0,t.P_)(this.agentIdentifier).distributed_tracing),e.sameOrigin)r=!0;else if(n.allowed_origins instanceof Array)for(var i=0;i 2&&void 0!==arguments[2])||arguments[2];super(r,n,Z.t,i),(0,t.OP)(r).xhrWrappable&&(this.dt=new W(r),this.handler=(e,t,r,n)=>(0,s.p)(e,t,r,n,this.ee),(0,k.u5)(this.ee),(0,k.Kf)(this.ee),function(r,n,i,o){function a(e){var t=this;t.totalCbs=0,t.called=0,t.cbTime=0,t.end=E,t.ended=!1,t.xhrGuids={},t.lastSize=null,t.loadCaptureCalled=!1,t.params=this.params||{},t.metrics=this.metrics||{},e.addEventListener("load",(function(r){_(t,e)}),(0,O.m$)(!1)),c.IF||e.addEventListener("progress",(function(e){t.lastSize=e.loaded}),(0,O.m$)(!1))}function s(e){this.params={method:e[0]},T(this,e[1]),this.metrics={}}function u(e,n){var i=(0,t.DL)(r);i.xpid&&this.sameOrigin&&n.setRequestHeader("X-NewRelic-ID",i.xpid);var a=o.generateTracePayload(this.parsedOrigin);if(a){var s=!1;a.newrelicHeader&&(n.setRequestHeader("newrelic",a.newrelicHeader),s=!0),a.traceContextParentHeader&&(n.setRequestHeader("traceparent",a.traceContextParentHeader),a.traceContextStateHeader&&n.setRequestHeader("tracestate",a.traceContextStateHeader),s=!0),s&&(this.dt=a)}}function d(e,t){var r=this.metrics,i=e[0],o=this;if(r&&i){var a=V(i);a&&(r.txSize=a)}this.startTime=(0,p.z)(),this.listener=function(e){try{"abort"!==e.type||o.loadCaptureCalled||(o.params.aborted=!0),("load"!==e.type||o.called===o.totalCbs&&(o.onloadCalled||"function"!=typeof t.onload)&&"function"==typeof o.end)&&o.end(t)}catch(e){try{n.emit("internal-error",[e])}catch(e){}}};for(var s=0;s 1?e[1]=i:e.push(i)}else e[0]&&e[0].headers&&s(e[0].headers,n)&&(this.dt=n);function s(e,t){var r=!1;return t.newrelicHeader&&(e.set("newrelic",t.newrelicHeader),r=!0),t.traceContextParentHeader&&(e.set("traceparent",t.traceContextParentHeader),t.traceContextStateHeader&&e.set("tracestate",t.traceContextStateHeader),r=!0),r}}function x(e,t){this.params={},this.metrics={},this.startTime=(0,p.z)(),this.dt=t,e.length>=1&&(this.target=e[0]),e.length>=2&&(this.opts=e[1]);var r,n=this.opts||{},i=this.target;"string"==typeof i?r=i:"object"==typeof i&&i instanceof Y?r=i.url:c._A?.URL&&"object"==typeof i&&i instanceof URL&&(r=i.href),T(this,r);var o=(""+(i&&i instanceof Y&&i.method||n.method||"GET")).toUpperCase();this.params.method=o,this.txSize=V(n.body)||0}function A(t,r){var n;this.endTime=(0,p.z)(),this.params||(this.params={}),this.params.status=r?r.status:0,"string"==typeof this.rxSize&&this.rxSize.length>0&&(n=+this.rxSize);var o={txSize:this.txSize,rxSize:n,duration:(0,p.z)()-this.startTime};i("xhr",[this.params,o,this.startTime,this.endTime,"fetch"],this,e.D.ajax)}function E(t){var r=this.params,n=this.metrics;if(!this.ended){this.ended=!0;for(var o=0;o 2&&void 0!==arguments[2])||arguments[2];super(e,t,we.t,r),this.importAggregator()}}new class{constructor(e){let t=arguments.length>1&&void 0!==arguments[1]?arguments[1]:(0,_.ky)(16);c._A?(this.agentIdentifier=t,this.sharedAggregator=new y({agentIdentifier:this.agentIdentifier}),this.features={},this.desiredFeatures=new Set(e.features||[]),this.desiredFeatures.add(m),Object.assign(this,(0,a.j)(this.agentIdentifier,e,e.loaderType||"agent")),this.start()):(0,l.Z)("Failed to initial the agent. Could not determine the runtime environment.")}get config(){return{info:(0,t.C5)(this.agentIdentifier),init:(0,t.P_)(this.agentIdentifier),loader_config:(0,t.DL)(this.agentIdentifier),runtime:(0,t.OP)(this.agentIdentifier)}}start(){const t="features";try{const r=n(this.agentIdentifier),i=[...this.desiredFeatures];i.sort(((t,r)=>e.p[t.featureName]-e.p[r.featureName])),i.forEach((t=>{if(r[t.featureName]||t.featureName===e.D.pageViewEvent){const n=function(t){switch(t){case e.D.ajax:return[e.D.jserrors];case e.D.sessionTrace:return[e.D.ajax,e.D.pageViewEvent];case e.D.sessionReplay:return[e.D.sessionTrace];case e.D.pageViewTiming:return[e.D.pageViewEvent];default:return[]}}(t.featureName);n.every((e=>r[e]))||(0,l.Z)("".concat(t.featureName," is enabled but one or more dependent features has been disabled (").concat((0,D.P)(n),"). This may cause unintended consequences or missing data...")),this.features[t.featureName]=new t(this.agentIdentifier,this.sharedAggregator)}})),(0,T.Qy)(this.agentIdentifier,this.features,t)}catch(e){(0,l.Z)("Failed to initialize all enabled instrument classes (agent aborted) -",e);for(const e in this.features)this.features[e].abortHandler?.();const r=(0,T.fP)();return delete r.initializedAgents[this.agentIdentifier]?.api,delete r.initializedAgents[this.agentIdentifier]?.[t],delete this.sharedAggregator,r.ee?.abort(),delete r.ee?.get(this.agentIdentifier),!1}}}({features:[J,m,S,class extends h{static featureName=oe;constructor(t,r){if(super(t,r,oe,!(arguments.length>2&&void 0!==arguments[2])||arguments[2]),!c.il)return;const n=this.ee;let i;(0,k.QU)(n),this.eventsEE=(0,k.em)(n),this.eventsEE.on(se,(function(e,t){this.bstStart=(0,p.z)()})),this.eventsEE.on(ae,(function(t,r){(0,s.p)("bst",[t[0],r,this.bstStart,(0,p.z)()],void 0,e.D.sessionTrace,n)})),n.on(ce+ne,(function(e){this.time=(0,p.z)(),this.startPath=location.pathname+location.hash})),n.on(ce+ie,(function(t){(0,s.p)("bstHist",[location.pathname+location.hash,this.startPath,this.time],void 0,e.D.sessionTrace,n)}));try{i=new PerformanceObserver((t=>{const r=t.getEntries();(0,s.p)(te,[r],void 0,e.D.sessionTrace,n)})),i.observe({type:re,buffered:!0})}catch(e){}this.importAggregator({resourceObserver:i})}},C,xe,B,class extends h{static featureName=de;constructor(e,r){if(super(e,r,de,!(arguments.length>2&&void 0!==arguments[2])||arguments[2]),!c.il)return;if(!(0,t.OP)(e).xhrWrappable)return;try{this.removeOnAbort=new AbortController}catch(e){}let n,i=0;const o=this.ee.get("tracer"),a=(0,k._L)(this.ee),s=(0,k.Lg)(this.ee),u=(0,k.BV)(this.ee),d=(0,k.Kf)(this.ee),f=this.ee.get("events"),l=(0,k.u5)(this.ee),h=(0,k.QU)(this.ee),g=(0,k.Gm)(this.ee);function m(e,t){h.emit("newURL",[""+window.location,t])}function v(){i++,n=window.location.hash,this[ve]=(0,p.z)()}function b(){i--,window.location.hash!==n&&m(0,!0);var e=(0,p.z)();this[pe]=~~this[pe]+e-this[ve],this[ye]=e}function y(e,t){e.on(t,(function(){this[t]=(0,p.z)()}))}this.ee.on(ve,v),s.on(be,v),a.on(be,v),this.ee.on(ye,b),s.on(ge,b),a.on(ge,b),this.ee.buffer([ve,ye,"xhr-resolved"],this.featureName),f.buffer([ve],this.featureName),u.buffer(["setTimeout"+le,"clearTimeout"+fe,ve],this.featureName),d.buffer([ve,"new-xhr","send-xhr"+fe],this.featureName),l.buffer([me+fe,me+"-done",me+he+fe,me+he+le],this.featureName),h.buffer(["newURL"],this.featureName),g.buffer([ve],this.featureName),s.buffer(["propagate",be,ge,"executor-err","resolve"+fe],this.featureName),o.buffer([ve,"no-"+ve],this.featureName),a.buffer(["new-jsonp","cb-start","jsonp-error","jsonp-end"],this.featureName),y(l,me+fe),y(l,me+"-done"),y(a,"new-jsonp"),y(a,"jsonp-end"),y(a,"cb-start"),h.on("pushState-end",m),h.on("replaceState-end",m),window.addEventListener("hashchange",m,(0,O.m$)(!0,this.removeOnAbort?.signal)),window.addEventListener("load",m,(0,O.m$)(!0,this.removeOnAbort?.signal)),window.addEventListener("popstate",(function(){m(0,i>1)}),(0,O.m$)(!0,this.removeOnAbort?.signal)),this.abortHandler=this.#e,this.importAggregator()}#e(){this.removeOnAbort?.abort(),this.abortHandler=void 0}}],loaderType:"spa"})})(),window.NRBA=o})(); window.jQuery || document.write(' ') CKEDITOR_BASEPATH='https://f1000research.com/js/vendor/ckeditor/' window.reactTheme = 'research'; window.MathJax = { CommonHTML: { linebreaks: { automatic: true } }, 'HTML-CSS': { linebreaks: { automatic: true } }, SVG: { linebreaks: { automatic: true } }, AuthorInit: function() { MathJax.Hub.Register.MessageHook('End Process', function () { let timeout = false; // holder for timeout id const delay = 250; // delay after event is "complete" to run callback const reflowMath = function() { const dispFormulas = document.querySelectorAll('.disp-formula.panel'); if (!dispFormulas) { return; } for (const dispFormula of dispFormulas) { const child = dispFormula.querySelector('.MathJax_Preview').nextSibling.firstChild; const isMultiline = MathJax.Hub.getAllJax(dispFormula)[0].root.isMultiline; if (dispFormula.offsetWidth < child.offsetWidth || isMultiline) { MathJax.Hub.Queue(['Rerender', MathJax.Hub, dispFormula]); } } }; window.addEventListener('resize', function() { clearTimeout(timeout); // clear the timeout timeout = setTimeout(reflowMath, delay); // start timing for event "completion" }); }); }, }; if (window.location.hash == '#_=_'){ window.location = window.location.href.split('#')[0] } !function(f,b,e,v,n,t,s){if(f.fbq)return;n=f.fbq=function() {n.callMethod? n.callMethod.apply(n,arguments):n.queue.push(arguments)} ;if(!f._fbq)f._fbq=n; n.push=n;n.loaded=!0;n.version='2.0';n.queue=[];t=b.createElement(e);t.async=!0; t.src=v;s=b.getElementsByTagName(e)[0];s.parentNode.insertBefore(t,s)}(window, document,'script','https://connect.facebook.net/en_US/fbevents.js'); fbq('init', '1641728616063202'); fbq('track', "PixelInitialized", {}); (function(h,o,t,j,a,r){ h.hj=h.hj||function(){(h.hj.q=h.hj.q||[]).push(arguments)}; h._hjSettings={hjid:2318163,hjsv:6}; a=o.getElementsByTagName('head')[0]; r=o.createElement('script');r.async=1; r.src=t+h._hjSettings.hjid+j+h._hjSettings.hjsv; a.appendChild(r); })(window,document,'https://static.hotjar.com/c/hotjar-','.js?sv='); search file_upload Submit your research search menu close search Browse Gateways & Collections How to Publish Submit your Research My Submissions Article Guidelines Article Guidelines (New Versions) Open Data, Software and Code Guidelines Open Data and Accessible Source Materials Guidelines (HSS) Open Data, Software and Code Guidelines (PSE) Prepublication Checks Production Process Posters and Slides Guidelines Document Guidelines Article Processing Charges Peer Review Finding Article Reviewers About How it Works For Reviewers Our Advisors Policies Glossary FAQs For Developers Newsroom Contact My Research Submissions Content and Tracking Alerts My Details Sign In file_upload Submit your research { "@context": "https://schema.org", "@type": "ScholarlyArticle", "mainEntityOfPage": { "@type": "WebPage", "@id": "https://f1000research.com/articles/12-766" }, "headline": "Evaluation by app in smartphones of awake bruxism at the return of presential classes in two...", "datePublished": "2023-06-30T16:02:55", "dateModified": "2024-08-05T16:11:16", "author": [ { "@type": "Person", "name": "Byron Velasquez Ron" }, { "@type": "Person", "name": "Veronica Mosquera Cisneros" }, { "@type": "Person", "name": "Pamela Pazmiño Troncoso" }, { "@type": "Person", "name": "Maria Rodriguez Tates" }, { "@type": "Person", "name": "Eddy Alvares Lalvay" }, { "@type": "Person", "name": "Luis Chauca Bajaña" }, { "@type": "Person", "name": "Andrea Ordoñez Balladares" } ], "publisher": { "@type": "Organization", "name": "F1000Research", "logo": { "@type": "ImageObject", "url": "https://f1000research.com/img/AMP/F1000Research_image.png", "height": 480, "width": 60 } }, "image": { "@type": "ImageObject", "url": "https://f1000research.com/img/AMP/F1000Research_image.png", "height": 1200, "width": 150 }, "description": " Background. The return to normality post-pandemic brought some inconveniences to the population, especially students. To evaluate the frequency of awake bruxism behaviors through the use of an app on smartphones in dental students returning to presential classes. Awake bruxism was evaluated with the creation of an app that according to the authors evaluates: relaxed jaw muscles, dental contact, jaw effort, clenching teeth and teeth grinding, 5 frequent oral conditions in the population. The frequency of awake/daytime bruxism (AB) in healthy individuals when comparing other populations with possible risk factors for additive bruxism (psychological factors, depression, suicide delusions, etc.), evaluating consequent clinical signs (fatigue, muscle pain, attritions and dental openings). Methods: The sample of three hundred (n=300) young adults legally enrolled in two Ecuadorian universities, the sample was selected among fifth, sixth, seventh, eighth and ninth semester students legally enrolled and who are attending Faculty of Dentistry classes in 2 different cities (Quito and Guayaquil). The app was configured to provide 20 alerts during the day x seven days a week, in real time. Results. The study obtained 95% reliability and 5% error in research, was used. The relaxation condition was present in all users, but 40% of the alerts were associated with jaw and tooth discomfort, 39% corresponded to the discomfort of mandibular clenching, and 24% corresponded to tooth contact. A direct significant association was found between the state of relaxation and nonrelaxation, with a high probability of reports related to nonrelaxation (p ≤ 0.05). Conclusions: Awake bruxism with the app was evaluated, identifying 5 behaviors such as: relaxed mandibular muscles, dental contact, mandibular effort, clenching and grinding teeth, frequent conditions in the population; reporting a state of mandibular relaxation, there is a high probability that a condition of nonrelaxation would be reported (p≤0.05)." } { "@context": "http://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": "1", "item": { "@id": "https://f1000research.com/", "name": "Home" } }, { "@type": "ListItem", "position": "2", "item": { "@id": "https://f1000research.com/browse/articles", "name": "Browse" } }, { "@type": "ListItem", "position": "3", "item": { "@id": "https://f1000research.com/articles/12-766", "name": "Evaluation by app in smartphones of awake bruxism at the return of..." } } ] } Home Browse Evaluation by app in smartphones of awake bruxism at the return of... ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article Velasquez Ron B, Mosquera Cisneros V, Pazmiño Troncoso P et al. Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.12688/f1000research.133946.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Research Article Revised Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] Byron Velasquez Ron https://orcid.org/0000-0001-5660-3941 1,2 , Veronica Mosquera Cisneros 2 , Pamela Pazmiño Troncoso 2 , [...] Maria Rodriguez Tates 2 , Eddy Alvares Lalvay https://orcid.org/0000-0002-7377-8003 2 , Luis Chauca Bajaña https://orcid.org/0000-0002-8713-951X 3 , Andrea Ordoñez Balladares 3 Byron Velasquez Ron https://orcid.org/0000-0001-5660-3941 1,2 , Veronica Mosquera Cisneros 2 , [...] Pamela Pazmiño Troncoso 2 , Maria Rodriguez Tates 2 , Eddy Alvares Lalvay https://orcid.org/0000-0002-7377-8003 2 , Luis Chauca Bajaña https://orcid.org/0000-0002-8713-951X 3 , Andrea Ordoñez Balladares 3 PUBLISHED 05 Aug 2024 Author details Author details 1 State University of New York University Center for Academic and Workforce Development, Manhathan, New York, USA 2 UDLA, Universidad de Las Americas, Quito, Via Nayon, 170523, Ecuador 3 Universidad de Guayaquil, Guayaquil, Guayas, Ecuador Byron Velasquez Ron Roles: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Investigation, Methodology, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Veronica Mosquera Cisneros Roles: Investigation, Methodology, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Pamela Pazmiño Troncoso Roles: Investigation, Methodology, Writing – Original Draft Preparation, Writing – Review & Editing Maria Rodriguez Tates Roles: Investigation, Methodology, Project Administration, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Eddy Alvares Lalvay Roles: Conceptualization, Investigation, Methodology, Writing – Original Draft Preparation, Writing – Review & Editing Luis Chauca Bajaña Roles: Investigation, Methodology, Writing – Original Draft Preparation, Writing – Review & Editing Andrea Ordoñez Balladares Roles: Investigation, Methodology, Writing – Original Draft Preparation, Writing – Review & Editing OPEN PEER REVIEW DETAILS REVIEWER STATUS Abstract Background . The return to normality post-pandemic brought some inconveniences to the population, especially students. To evaluate the frequency of awake bruxism behaviors through the use of an app on smartphones in dental students returning to presential classes. Awake bruxism was evaluated with the creation of an app that according to the authors evaluates: relaxed jaw muscles, dental contact, jaw effort, clenching teeth and teeth grinding, 5 frequent oral conditions in the population. The frequency of awake/daytime bruxism (AB) in healthy individuals when comparing other populations with possible risk factors for additive bruxism (psychological factors, depression, suicide delusions, etc.), evaluating consequent clinical signs (fatigue, muscle pain, attritions and dental openings). Methods : The sample of three hundred (n=300) young adults legally enrolled in two Ecuadorian universities, the sample was selected among fifth, sixth, seventh, eighth and ninth semester students legally enrolled and who are attending Faculty of Dentistry classes in 2 different cities (Quito and Guayaquil). The app was configured to provide 20 alerts during the day x seven days a week, in real time. Results . The study obtained 95% reliability and 5% error in research, was used. The relaxation condition was present in all users, but 40% of the alerts were associated with jaw and tooth discomfort, 39% corresponded to the discomfort of mandibular clenching, and 24% corresponded to tooth contact. A direct significant association was found between the state of relaxation and nonrelaxation, with a high probability of reports related to nonrelaxation (p ≤ 0.05). Conclusions: Awake bruxism with the app was evaluated, identifying 5 behaviors such as: relaxed mandibular muscles, dental contact, mandibular effort, clenching and grinding teeth, frequent conditions in the population; reporting a state of mandibular relaxation, there is a high probability that a condition of nonrelaxation would be reported (p≤0.05). READ ALL READ LESS Keywords bruxism, ecological momentary assessment, smartphone, prevalence, COVID-19 pandemic. Corresponding Author(s) Byron Velasquez Ron ( [email protected] ) Close Corresponding author: Byron Velasquez Ron Competing interests: No competing interests were disclosed. Grant information: The author(s) declared that no grants were involved in supporting this work. Copyright: © 2024 Velasquez Ron B et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The author(s) is/are employees of the US Government and therefore domestic copyright protection in USA does not apply to this work. The work may be protected under the copyright laws of other jurisdictions when used in those jurisdictions. How to cite: Velasquez Ron B, Mosquera Cisneros V, Pazmiño Troncoso P et al. Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.12688/f1000research.133946.2 ) First published: 30 Jun 2023, 12 :766 ( https://doi.org/10.12688/f1000research.133946.1 ) Latest published: 05 Aug 2024, 12 :766 ( https://doi.org/10.12688/f1000research.133946.2 ) Revised Amendments from Version 1 Responding to the reviewers, indicating that the verb evaluation was abstract around the research topic, they recommended using the verb monitor. The objective was corrected by clarifying the goal of the research in a better way, expanding the section of materials and methods with better explanation on the recommendation of the reviewers, the conclusion as it should respond to the objective was also revised. In the introduction, the wording is improved by including references suggested by the reviewers that justify the topic to be investigated. In the materials and methods, contact is made with the creators of the app via email, confirming the authorship of the same, making the application free. Table 1 with the suggested indications is changed. In the discussion it is completely reorganized, the language and references are reviewed, the suggestions to discuss clearly about the use of the app and the follow-up it provides on Awake bruxism are respected, the result of the state of relaxation that the patients had is also discussed, contrasting with other studies that applied EMA fundamental basis of the application. The conclusion is reviewed when the objective is found that the first 4 days of monitoring in the bruxism app showed symptoms such as discomfort in the jaw and teeth, from day 4 the students answered in the record of the alerts in the app that they felt relaxed, according to authors it was due to the brain action that they generate unconsciously to self-control, let's remember that Awake Bruxism is an activity that the patient does not know he has but that is generated in summer hours, for this reason scientists justify that the human brain reconditions its reactions so that it becomes preventive or is on alert of a diagnosed condition. Responding to the reviewers, indicating that the verb evaluation was abstract around the research topic, they recommended using the verb monitor. The objective was corrected by clarifying the goal of the research in a better way, expanding the section of materials and methods with better explanation on the recommendation of the reviewers, the conclusion as it should respond to the objective was also revised. In the introduction, the wording is improved by including references suggested by the reviewers that justify the topic to be investigated. In the materials and methods, contact is made with the creators of the app via email, confirming the authorship of the same, making the application free. Table 1 with the suggested indications is changed. In the discussion it is completely reorganized, the language and references are reviewed, the suggestions to discuss clearly about the use of the app and the follow-up it provides on Awake bruxism are respected, the result of the state of relaxation that the patients had is also discussed, contrasting with other studies that applied EMA fundamental basis of the application. The conclusion is reviewed when the objective is found that the first 4 days of monitoring in the bruxism app showed symptoms such as discomfort in the jaw and teeth, from day 4 the students answered in the record of the alerts in the app that they felt relaxed, according to authors it was due to the brain action that they generate unconsciously to self-control, let's remember that Awake Bruxism is an activity that the patient does not know he has but that is generated in summer hours, for this reason scientists justify that the human brain reconditions its reactions so that it becomes preventive or is on alert of a diagnosed condition. See the authors' detailed response to the review by Maria Beatriz Duarte Gaviao See the authors' detailed response to the review by Swapna B V and kavishma Sulaya READ REVIEWER RESPONSES Background Bruxism is a debated topic, especially when considering dental clinical manifestations and their relationships with other medical specialties, 1 causing controversy in confronting effects and consequences. A panel of experts, including dentists, psychologists, and specialists in pain and facial pain, defined bruxism using strategies such as polysomnography (PSG) and electromyography (EMG) 2 to determine whether it is triggered by specific clinical signs such as involuntary movements 3 in the chewing muscles. 4 There are many studies on this topic; unfortunately, scientific evidence on awake bruxism is limited. The concept of awake bruxism is currently considered muscular activity during wakefulness that is characterized by repetitive or sustained dental contact, accompanied by pushes or mandibular reinforcements (movements) during a person’s conscious activities, which is not necessarily pathological but has clinical consequences. 5 , 6 When comparing populations, awake bruxism has risk factors such as mental disorders, depression, and suicidal delusions, among others, with clinical signs such as fatigue, muscle pain, dental attrition, and temporomandibular joint pain, suggesting the need for the evaluation of intercultural comparisons, social strata and lifestyle habits. 7 Evaluation can be performed with noninstrumental approaches such as self-reports (anamnestic questionnaires), clinical observation, instrumental evaluation using electromyography (EMG), and ecological momentary assessment (EMA) strategies. 2 , 8 , 9 EMA allows us to collect data in real time over a given period of time by recording multiple coincident points in the environment. 10 – 12 This instrumentation goes beyond retrospective questionnaires, making EMA very useful in the evaluation of oral activity. The limitation of EMA is that the data are fragmented, as only specific behaviors are selected. 13 – 15 To control this bias, in Italy, the research group under Professor Alessandro Bracci at the University of Pavoda created a smartphone app, which incorporates EMA to collect data on dental contact, jaw clenching, tooth compression and teeth grinding. 16 , 17 The application provides data on the frequency of awake bruxism behaviors (clinical signs entered into the application) over a period of one week, with evaluation 4 times per day. These data are stored in the memory of the phone. After the evaluation time, we obtained data on the percentage and frequency of clinical signs. 18 The objective of this study was to monitor the frequency of awake bruxism behaviors in dental students by using a smartphone app. Materials and Methods Approval was obtained from the Bioethics Committee of the University of the Americas (CEBE-2022-0601). Three hundred (n = 300) young adults who were legally enrolled in two different Ecuadorian universities (*UDLA/UESG) in Quito and Guayaquil were randomly selected after signing the informed consent form and agreeing to participate in the study. They underwent a one-week registration period with a smartphone app (BruxApp Research ® , Pontedera, Italy) developed by Dr. Alessandro Bracci et al., with the aim of reporting and monitoring the frequency of AB behaviors in their natural environment; this free application can be accessed via Google Pay and the App store. The students were made aware of the responsibility of participating in the research, making their country and their university known to the world. The sample included fifth-, sixth-, seventh-, eighth- and ninth-semester students who were legally enrolled and who were attending face-to-face classes conducted by the Faculty of Dentistry at two different Ecuadorian universities (Quito and Guayaquil). The inclusion criteria included having recent generation smartphones, good general health and the absence of temporomandibular joint disorder (TMD)/orofacial pain and/or any documented degenerative, neurological or systemic disease (e.g., rheumatological disease, hormonal disease). An informative meeting was held during which the students maintained contact with the principal investigators (BV, VM, PP, MRT, EAL, LCH, and AO). During that session, the objective of the study was explained, and training was provided on how to use the app ( Figure 1 ). Figure 1. Flow diagram research. The Bruxism APP collects a person’s data in a self-informed way in their daily life with an EMA approach (ecological approach), sending random messages during the day that alert the person of the conditions of their teeth and jaw muscles; individuals must respond within 5 minutes by touching the cone of the screen of their cell phone and indicating the current condition of their jaw muscles: jaw muscle relaxation, teeth contact, jaw clenching, teeth clenching and teeth grinding. The objective of the study was explained while providing training for the correct use of the application ( Figure 1 ). The students were instructed to download the BruxApp and asked to start their first data collection session the next morning, which included 20 alerts per day at random intervals. The participants were instructed to comply with at least 60% of the requests per day (answering within the first 5 minutes; otherwise, the screen sent an error message) Students who responded to <60% of the alerts were excluded from the study automatically. Data were recorded during a period of 7 days, the records were calibrated from 8.00 to 12.30 and from 14.30 to 22.00, and the participants were instructed to ignore alerts during meals and particular activities (smoking, singing). The application records were recorded all day. After seven valid days of recordings, the software generated an anonymous .csv file, which the students sent to the researchers via prearranged emails. The data were collected by the lead author (B. V.) in collaboration with two resident dentists of the Specialty of Oral Rehabilitation (V. M., P. P., MRT, and EAL) of dentistry and two professors (LCH and A. of the Faculty of Dentistry of the University of Guayaquil). To maximize the recording window, lunchtime was excluded because the participants were instructed to ignore alerts during meals and activities (smoking, singing). If the minimum number of valid responses per day was not obtained, the software automatically added another recording day to ensure completion of the 7-day protocol. For the study of awake bruxism, the chi-square test ( Table 1 ) was used to determine the association between muscle relaxation and nonrelaxation. In the alerts from the app, in the first stage, the muscles were not in occlusal contact (maximum intercuspation); in the second stage, there was occlusal contact (maximum intercuspation) and clenching of the jaw and teeth accompanied by grinding. The existing correlation was direct despite being in different contexts, demonstrating that the conditions were present during the conscious activity of the person (awake). When reporting mandibular relaxation, there was a high probability that muscle relaxation was reported in the application (p≤0.05). Table 1. Significance test. Chi-square tests Valor gl Asymptotic significance (bilateral) Pearson's Chi-square 1200.000 † 16 <.001 Likelihood ratio 902.565 16 <.001 Linear-by-linear association 299.000 1 <.001 N. of valid cases 300 † 9 boxes (36.0%) had an expected count of less than 5. The minimum expected count was 0.56. Results Assuming 95% reliability and 5% error in the research, a sample size of 300 young adults from the two universities involved in the study was included in simple random sampling model. The research was characterized by analyzing variables such as sex and age ( Table 2 ). Table 2. Distribution of the sample by sex. Sex † n %n Female 253 84.33 Male 47 15.67 Total ‡ 300 100 † Sex. ‡ Total Sex. The proportion of females among the selected sample was 84.33%, compared with that of 15.67% for males. Thus, the proportion of females in this study was significantly greater than that of males. A total of 79% of the participants were aged 21 to 22 years, which was expected since this sample set consisted of young adults studying at a university ( Table 3 ). Table 3. Distribution of the sample by age. Age (years) § n %n 19 30 10 21 134 44.7 22 104 34.7 23 10 3.33 24 1 0.33 25 12 4 26 6 2 27 1 0.33 32 2 0.67 Total ¶ 300 100 § Age. ¶ Total Ages. Relaxation was evident in all users, but 40% of the alerts were associated with jaw and tooth discomfort, 39% corresponded to mandibular clenching, and 24% corresponded to tooth contact ( Table 4 ). Table 4. Distribution of alerts according to user conditions. Conditions Alerts % Relaxed 3652 68.9 Jaw clenching § 917 15.28 Tooth contact 573 9.55 Tooth clenching 487 8.12 Pain when opening/closing the mouth 142 2.37 Daytime pressure 142 2.37 Teeth grinding 70 1.17 Difficulty opening the mouth when waking up 10 0.17 Sore teeth 7 0.12 Total 6000 100 § Jaw clenching was most relevant Thus, among the aforementioned symptoms, 63% of the alerts sent by BruxApp were related to specific symptoms. The study was conducted in one week: on the first day, 33% of the participants reported discomfort; on the second day, 61% reported maxillary discomfort; on the third day, 64% reported decreased discomfort; on the fourth day, 21% reported a decrease in discomfort; on the fifth day, the discomfort percentage was maintained; on the sixth day, 41% of the participants reported being relaxed; and on the seventh day, the percentage of participants who reported being relaxed increased by 51% ( Table 5 ). Table 5. Distribution of alerts according to condition among sex and age groups. Sex/Age (Groups) Females years Males years Condition 18/21 years 22/25 years 26/32 years Total 18/21 years 22/25 years Total Grand Total Relaxed Alerts 1644 1308 115 3067 295 290 585 3652 %Alerts 45.2 35.82 3.19 83.98 8.08 7.94 16.02 100 Tooth clenching Alerts 242 164 11 417 42 28 70 487 %Alerts 49.69 33.48 2.26 85.63 8.62 5.7 14.37 100 Jaw clenching Alerts 442 307 25 774 83 60 143 917 %Alerts 48.20 33.48 2.73 84.41 9.05 6.54 15.59 100 Sore teeth Alerts 1 1 5 7 0 0 0 7 %Alerts 14.29 14.29 71.43 100 0 0 0 100 Tooth contact Alerts 277 194 15 486 50 37 87 73 %Alerts 48.34 33.86 2.62 84.82 8.73 6.46 15.18 100 Difficulty opening the mouth upon waking Alerts 5 5 0 10 0 0 0 10 %Alerts 50 50 0 100 0 0 0 100 Pain when opening/closing the mouth Alerts 67 48 5 120 12 10 22 142 %Alerts 47.18 33.8 3.52 84.51 8.45 7.04 15.5 100 Daytime pressure Alerts 68 48 4 120 12 10 22 142 %Alerts 47.89 33.8 2.82 84.51 8.45 7.04 15.5 100 Teeth grinding Alerts 34 25 0 59 6 5 11 70 %Alerts 48.57 35.71 0 84.29 8.57 7.14 15.71 100 Total Alerts 2780 2100 180 5060 500 440 940 6000 %Alerts 46.33 35 3 84.33 8.33 7.33 15.7 100 Discussion The collection of heterogeneous information, the calibration of personal self-reports and group reports on phones, and training in the use of the smartphone app facilitated the data collection. The included population of dental students may have had a positive influence on the results, as having knowledge of what the app is measuring limited the bias in the study. The app used in the study to monitor the frequency of AB behavior revealed that the symptomatology found was more significant in 84% of women aged 21 to 22 years, and the daily use of technology by young people was helpful in their fulfillment of responses to the alerts of the app. This information coincides with what was proposed by Dias et al. in 2021, which indicates that the use of the EMA approach in smartphone programs for monitoring AB behaviors was useful in the long term, making individuals aware of the recognition of the different pathologies considered by the application. 19 , 20 The BruxApp provides various frequencies and percentages depending on sex and age groups; 32.13% of women and 5.91% of men reported experiencing maxillary discomfort, justifying its diagnostic importance. The report indicated that 68.9% of alerts received responses regarding a state of relaxation (without jaw discomfort). 21 , 22 When excluding the state of relaxation, mandibular clenching had the greatest significance at 39%. Monitoring the nonrelaxation state with five specific conditions included in the app, such as jaw muscle relaxation, tooth contact, jaw force, teeth clenching, and teeth grinding, resulted in the collection of data for >6000 alerts (20 alerts × 300 participants × 7 days). During the 7-day observation period, data on 42000 alerts were collected. Zani et al. (2021) used the BruxApp in 2 Italian universities for monitoring AB behaviors by assessing the state of relaxation and nonrelaxation, coinciding with 5 conditions: relaxation of the mandibular musculature, 76.4%; contact with teeth, 13.6%; mandibular bracing, 7.0%; teeth clenching, 2.5%; and teeth grinding, 0.5%.21,22 Data collected using the EMA approach in observational studies indicate a reference in the frequency of AB behaviors, indicating that predisposing factors may vary in women under normal conditions, stress factors, and hormonal factors. 23 , 24 Jaw clenching was the most frequently reported, at 15.28%, and dental pain was the least frequently reported, at 0.17%, and the combined frequency of AB in a state of nonrelaxation was 23.6% 25 ; the consideration of psychological factors within the etiology of AB, which relates to sex, provides a statistical variable indicating that men control their emotions better 26 than women do. Studies conducted by Bracci et al. (2018) showed similarities with our study, revealing a slight difference in sex when monitoring AB behaviors with EMAs, which was not a determinant of the outcome. 10 , 27 No statistically significant differences were found between the population participating in the research (UDLA; USG), the self-reported strategies for AB, which helped in the data collection, and the alerts generated by the app during the 7-day monitoring period, which controlled the bias of the study due to the alarm that was activated according to the program. 28 , 29 The alerts generated in the evaluation by using the application provided diverse results: 33% of participants reported experiencing jaw discomfort the first day, 61% reported it on the second day, 64% reported it on the third day, 21% reported it on the fourth day, the result did not change on the fifth day, 41% reported experiencing relaxation on the sixth day, and 51% reported experiencing relaxation on the seventh day. The natural fluctuation in the recognition consisting of the symptomatology reported regarding the specific AB behaviors recorded in the app demonstrates considerable variability. 30 , 31 These findings indicate that relaxed muscles are recognized in a high percentage of the investigated population, taking the baseline results as a starting point when evaluating the combined frequencies of all the symptoms of AB indicated in the app. 32 , 33 The EMA strategy used in the smartphone application indicated a medium frequency value that provided reliability in monitoring AB behaviors, reducing the influence of natural fluctuations directly related to the specific symptomatology. 34 , 35 Unfortunately, e-mail registration limited daytime contact with the patients with TMD, 36 , 37 and it is recommended that future research evaluate the increase or decrease in the frequency of AB symptoms, relating them to eating habits, smoking habits, medication use, and psychological problems. 38 , 39 Compared with the findings of other similar studies that have contributed to updating the concept of bruxism by providing strategic evaluation options, 40 , 41 population comparisons will be made better by translating the BruxApp 42 , 43 into several languages, which opens the possibility of conducting multicenter epidemiological research on bruxism. Conclusion During 7 days of monitoring the frequency of AB behaviors through a smartphone app, the student population experienced discomfort in the jaw and teeth in the first 4 days, reaching a state of relaxation on the seventh day. Data availability Zenodo. Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers, https://doi.org/10.5281/zenodo.7979723 . 43 This project contains the following underlying data: • Table 1: Significance test • Table 2.docx (Data of distribution of the sample by gender) • Table 3.docx (Data of distributions of sample by age) • Table 4.docx (Data of distribution of alerts according to user conditions) • Table 5.docx (Data of distribution of alerts according to condition among sex and age groups) Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0). Acknowledgments The authors would like to express their special thanks to Universidad de Las Américas. References 1. Emodi A, Manfredini D, Shalev T, et al. : Awake Bruxism-Single-Point Self-Report versus Ecological Momentary Assessment. J. Clin. Med. 2021 Apr 15; 10 (8): 1699. PubMed Abstract | Publisher Full Text | Free Full Text 2. Lobbezoo F, Ahlberg J, Raphael KG, et al. : International consensus on the assessment of bruxism: Report of a work in progress. J. Oral Rehabil. 2018 Nov; 45 (11): 837–844. PubMed Abstract | Publisher Full Text | Free Full Text 3. De Baat C, Verhoeff M, Ahlberg J, et al. : Medications and addictive substances potentially inducing or attenuating sleep bruxism and/or awake bruxism. J. Oral Rehabil. 2021 Mar; 48 (3): 343–354. PubMed Abstract | Publisher Full Text | Free Full Text 4. Lobbezoo F, Ahlberg J, Glaros AG, et al. : Bruxism defined and graded: An international consensus. J. Oral Rehabil. 2013 Jan; 40 (1): 2–4. PubMed Abstract | Publisher Full Text 5. Matthew N, Manchery N: Can chronic oral inflammation and masticatory dysfunction contribute to cognitive impairment? Curr. Opin. Psychiatry. 2020 Mar; 33 (2): 156–162. Publisher Full Text 6. Emodi A, Manfredini D, Shalev T, et al. : Psychosocial and Behavioral Factors in Awake Bruxism-Self-Report versus Ecological Momentary Assessment. J. Clin. Med. 2021 Sep 27; 10 (19): 4447. PubMed Abstract | Publisher Full Text | Free Full Text 7. Souza M, Carvalho A, Fugueredo O, et al. : Awake bruxism frequency and psychosocial factors in college preparatory students. Cranio. 2020 Oct 14; 1–7. 8. Bracci A, Lange M, Djukic G, et al. : Ecological momentary assessment of awake bruxism behaviors: Possible developments and clinical usefulness of a smartphone application. Front. Neurol. 2019 Mar 5; 10 : 170. 9. Marpaung C, van Selms MKA , Lobbezoo F: Prevalence and risk indicators of pain-related temporomandibular disorders among Indonesian children and adolescents. Community Dent. Oral Epidemiol. 2018 Aug; 46 (4): 400–406. PubMed Abstract | Publisher Full Text 10. Bastani P, Manchery N, Samadbeik M, et al. : Digital Health in Children’s Oral and Dental Health: An Overview and a Bibliometric Analysis. Children. 2022; 9 : 1039. Publisher Full Text 11. Shopova D, Bozhkova T, Yordanova S, et al. : Case Report: Digital analysis of occlusion with T-Scan Novus in occlusal splint treatment for a patient with bruxism. F1000Res. 2022; 10 : 10. Publisher Full Text 12. Kaplan S, Ohrbach R: Self-Report of Waking-State Oral Parafunctional Behaviors in the Natural Environment. J. Oral Facial Pain Headache. Spring 2016; 30 (2): 107–119. PubMed Abstract | Publisher Full Text 13. Dias R, Rodrigues M, Serra J, et al. : Utility of Smartphone-based real-time report (Ecological Momentary Assessment) in the assessment and monitoring of awake bruxism: A multiple-week interval study in a Portuguese population of university students. J. Oral Rehabil. 2021 Dec; 48 (12): 1307–1313. PubMed Abstract | Publisher Full Text 14. Bracci A, Djukic G, Favero L, et al. : Frequency of awake bruxism behaviours in the natural environment. A 7-day, multiple-point observation of real-time report in healthy young adults. J. Oral Rehabil. 2018 Jun; 45 (6): 423–429. Publisher Full Text 15. Lavigne G, Rompré P, Montplaisir J: Sleep bruxism: Validity of clinical research diagnostic criteria in a controlled polysomnographic study. J. Dent Res. 1996; 75 (1): 546–552. PubMed Abstract | Publisher Full Text 16. Funato M, Ono Y, Baba K, et al. : Evaluation of the non-functional tooth contact in patients with temporomandibular disorders by using newly developed electronic system. J. Oral Rehabil. 2014; 41 (3): 170–176. PubMed Abstract | Publisher Full Text | Free Full Text 17. Heboyan A, Karobai M, Hamed A, et al. : Bruxism as a Consequence of Stress and Movement Disorders: Brief Review. Eur. J. Gen. Dent. 2022; 11 : 081–083. Publisher Full Text 18. Manfredini D, Bracci A, Djukic G: BruxApp: the ecological momentary assessment of awake bruxism. Minerva Stomatol. 2016 Aug; 10 (4): 252–255. PubMed Abstract | Publisher Full Text | Free Full Text 19. Zani A, Lobbezoo F, Bracci A, et al. : Smartphone based evaluation of awake bruxism behaviors in a sample of healthy young adults findings from two University centers. J. Oral Rehabil. 2021 Sep; 48 (9): 989–995. PubMed Abstract | Publisher Full Text | Free Full Text 20. Colonna A, Lobardo L, Siciliani G, et al. : Smartphone-based application for EMA assessment of awake bruxism: compliance evaluation in a sample of healthy young adults. Clin. Oral Investig. 2020 Apr; 24 (4): 1395–1400. Publisher Full Text 21. Goldstein R, Auclair W: The clinical management of awake bruxism. J. Am. Dent. Assoc. 2017 Jun; 148 (6): 387–391. Publisher Full Text 22. Bulanda S, Ilczuk D, Nitecka A, et al. : Sleep Bruxism in Children: Etiology, Diagnosis, and Treatment-A Literature Review. Int. J. Environ. Res. Public Health. 2021 Sep 10; 18 (18): 9544. PubMed Abstract | Publisher Full Text | Free Full Text 23. Cavallo P, Carpinelli L, Savarese G: Perceived stress and bruxism in university students. BMC. Res. Notes. 2016 Dec 21; 9 (1): 514. PubMed Abstract | Publisher Full Text | Free Full Text 24. Manfredini D, Serra J, Carboncini F, et al. : Current Concepts of Bruxism. Int. J. Prosthodont. September/October 2017; 30 (5): 437–438. PubMed Abstract | Publisher Full Text 25. Bracci A, Djukic G, Salmaso L, et al. : Frequency of awake bruxism behaviours in the natural environment. A 7-day, multiple-point observation of real-time report in healthy young adults. J. Oral Rehabil. 2018 Jun; 45 (6): 423–429. PubMed Abstract | Publisher Full Text 26. Shopova D, Mladenov K: Case Report: A digital workflow in the treatment of bruxism in a young patient. F1000Res. 2022; 10 : 10. Publisher Full Text 27. Thymi M, Rollman A, Visscher C, et al. : Experience with bruxism in the everyday oral implantology practice in the Netherlands: a qualitative study. BDJ Open. 2018 Nov 9; 4 : 17040. PubMed Abstract | Publisher Full Text | Free Full Text 28. Manfredini D, Ahlberg G, Bracci A, et al. : Towards a Standardized Tool for the Assessment of Bruxism (STAB)-Overview and general remarks of a multidimensional bruxism evaluation system. J. Oral Rehabil. 2020 May; 47 (5): 549–556. PubMed Abstract | Publisher Full Text 29. Shopova D, Yordanova M, Yordanova S, et al. : Software Details in Occlusal Splint Creation through 3Shape Design Studio. Open Access Maced. J. Med. Sci. 2021; 9 (D): 330–335. Publisher Full Text 30. Mark A: What is bruxism? J. Am. Dent. Assoc. 2021 Sep; 152 (9): 788. Publisher Full Text 31. Nagappan N, Madhanmohan R, Manchery N, et al. : Oral Health-Related Quality of Life and Dental Caries Status in Children With Orofacial Cleft: An Indian Outlook. J. Pharm. Bioallied Sci. 2019 May; 11 (Suppl 2): S169–S174. Publisher Full Text 32. Hardy R, Bonsor S: The efficacy of occlusal splints in the treatment of bruxism: A systematic review. J. Dent. 2021 May; 108 : 103621. PubMed Abstract | Publisher Full Text 33. Dadnam D, Dadnam C, Al-Saffar H: Pandemic bruxism. Br. Dent. J. 2021 Mar; 230 (5): 271. PubMed Abstract | Publisher Full Text | Free Full Text 34. Sabbagh H, Sabbagh A, Heppner A, et al. : Patients’ perceptions on temporomandibular disorder treatment with hydrostatic oral splints - a pilot study. BDJ Open. 2022 Feb 5; 8 (1): 4. PubMed Abstract | Publisher Full Text | Free Full Text 35. Duanmu Z, Liu L, Ren Y, et al. : Development of a biomechanical model for dynamic occlusal stress analysis. Int. J. Oral Sci. 2021; 13 : 29. PubMed Abstract | Publisher Full Text | Free Full Text 36. Goldstein G, DeSantis L, Goodcacre C: Bruxism: Best Evidence Consensus Statement. J. Prosthodont. 2021 Apr; 30 (S1): 91–101. Publisher Full Text 37. Manfredini D, Colonna A, Bracci A, et al. : Bruxism: a summary of current knowledge on aetiology, assessment and management. Oral Surg. 2020; 13 (4): 358–370. Publisher Full Text 38. Youny S, Salinas T, Wiens J: The effect of patient specific factors on oclussal forces generated: best evidence consensus statement. J. Prosthodont. 2021; 30 (S1): 52–60. Publisher Full Text 39. Malvin N, Lobbezzo F, Karen S, et al. : Stress-evoked muscle activity in women with and without chronic myofascial face pain. J. Oral Rehabil. 2021; 48 : 1089–1098. 40. Pereira NC, Oltramari PVP, Conti PCR, et al. : Frequency of awake bruxism behaviour in orthodontic patients: Randomised clinical trial: Awake bruxism behaviour in orthodontic patients. J. Oral Rehabil. 2021 Apr; 48 (4): 422–429. PubMed Abstract | Publisher Full Text 41. Silva T, Ortiz F, Maracci L, et al. : Association among headache, temporomandibular disorder, and awake bruxism: A cross-sectional study. Headache. 2022 Jun; 62 (6): 748–754. Publisher Full Text 42. Velásquez Ron B, Mosquera Cisneros V, Pazmiño Troncoso P, et al. : Monitoring of awake bruxism by intelligent app. F1000Res. 2022; 11 : 479. PubMed Abstract | Publisher Full Text | Free Full Text 43. Velasquez Ron B, Rodriguez Tates M: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers. Zenodo. F1000Res. 2023; 1 (23): 215. Publisher Full Text Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 30 Jun 2023 ADD YOUR COMMENT Comment Author details Author details 1 State University of New York University Center for Academic and Workforce Development, Manhathan, New York, USA 2 UDLA, Universidad de Las Americas, Quito, Via Nayon, 170523, Ecuador 3 Universidad de Guayaquil, Guayaquil, Guayas, Ecuador Byron Velasquez Ron Roles: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Investigation, Methodology, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Veronica Mosquera Cisneros Roles: Investigation, Methodology, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Pamela Pazmiño Troncoso Roles: Investigation, Methodology, Writing – Original Draft Preparation, Writing – Review & Editing Maria Rodriguez Tates Roles: Investigation, Methodology, Project Administration, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Eddy Alvares Lalvay Roles: Conceptualization, Investigation, Methodology, Writing – Original Draft Preparation, Writing – Review & Editing Luis Chauca Bajaña Roles: Investigation, Methodology, Writing – Original Draft Preparation, Writing – Review & Editing Andrea Ordoñez Balladares Roles: Investigation, Methodology, Writing – Original Draft Preparation, Writing – Review & Editing Competing interests No competing interests were disclosed. Grant information The author(s) declared that no grants were involved in supporting this work. Article Versions (2) version 2 Revised Published: 05 Aug 2024, 12:766 https://doi.org/10.12688/f1000research.133946.2 version 1 Published: 30 Jun 2023, 12:766 https://doi.org/10.12688/f1000research.133946.1 Copyright © 2024 Velasquez Ron B et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The author(s) is/are employees of the US Government and therefore domestic copyright protection in USA does not apply to this work. The work may be protected under the copyright laws of other jurisdictions when used in those jurisdictions. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Velasquez Ron B, Mosquera Cisneros V, Pazmiño Troncoso P et al. Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.12688/f1000research.133946.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 2 VERSION 2 PUBLISHED 05 Aug 2024 Revised Views 0 Cite How to cite this report: de Araujo G. Reviewer Report For: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.5256/f1000research.168484.r328134 ) The direct URL for this report is: https://f1000research.com/articles/12-766/v2#referee-response-328134 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 16 Oct 2024 Gabriela de Araujo , Universidade Federal de Santa Maria, Santa Maria, Brazil Not Approved VIEWS 0 https://doi.org/10.5256/f1000research.168484.r328134 Dear authors, investigating the frequency of behaviors related to awake bruxism, especially in a sample of university students, is important given the increased incidence of this outcome. The topic and idea of the study is relevant, since the use of ... Continue reading READ ALL Dear authors, investigating the frequency of behaviors related to awake bruxism, especially in a sample of university students, is important given the increased incidence of this outcome. The topic and idea of the study is relevant, since the use of apps can help change behavior and help identify important signs. However, the study has significant errors in the writing, limiting readers' comprehension on several points. In addition, the shows insufficiency of important information, especially in the study's methodology, could lead to future studies being reproduced. After reading, some aspects could be clarified to improve the article, so please leave your comments below. #Abstract: -The methodology section shows insufficient important information for an initial understanding of the study. How does the app assess the frequency of bruxism? It's not clear how the app identifies the behaviors of tooth contact, muscle relaxation, teeth grinding and the apartment. -Describe the statistical analysis used. #Introduction: - Bruxism has different types of classification depending on how the diagnosis is made. In this case, as the bruxism was self-reported by the student through the app, the most correct term to describe it is “possible bruxism”. Please take care to use the correct term throughout the study. - Please reference the following sentence: “When comparing populations, awake bruxism has risk factors such as mental disorders, depression, and suicidal delusions, among others” - Please describe in the introduction a study from the last five years that has assessed possible awake bruxism in students, and what the associated factors are. The introduction also shows insufficiency data on the prevalence of this condition, especially in relation to the study sample (young students). - Are there any studies that have evaluated bruxism-related apps? If so, please describe. #Methods: - Please include that “possible awake bruxism” was assessed through the participants' self-report; -Important information on data collection is missing. How were participants contacted to take part in the study and download the app? When was the study carried out? Was it after the COVID-19 pandemic? - Why were only university students from recent semesters included? Were only dental students considered? It is not clear here. - Why was there no sample calculation? Especially in descriptive studies, this is unpredictable. I suggest calculating the power of the study. - The statistical analysis part is not very clear. Be careful when relating the chi-square test to the expression “association”. The statistical analysis was carried out to check the distribution of the sample (frequencies) and not associations. #Results: - There are many tables that don't need to exist. I suggest adding the distribution tables for the sex and age variables. I also suggest classifying the age variable categorically (adolescents, young adults and adults) according to the World Health Organization classification. Is the work clearly and accurately presented and does it cite the current literature? Partly Is the study design appropriate and is the work technically sound? No Are sufficient details of methods and analysis provided to allow replication by others? No If applicable, is the statistical analysis and its interpretation appropriate? Partly Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? No Competing Interests: No competing interests were disclosed. Reviewer Expertise: dentistry; pediatric dentistry; social and preventive dentistry; epidemiology. I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT de Araujo G. Reviewer Report For: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.5256/f1000research.168484.r328134 ) The direct URL for this report is: https://f1000research.com/articles/12-766/v2#referee-response-328134 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Medina D. Reviewer Report For: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.5256/f1000research.168484.r328132 ) The direct URL for this report is: https://f1000research.com/articles/12-766/v2#referee-response-328132 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 11 Oct 2024 Dyanne Medina , University of São Paulo, São Paulo, Brazil Not Approved VIEWS 0 https://doi.org/10.5256/f1000research.168484.r328132 In the abstract, I can identify some deficiencies in the study. The second sentence begins with "To" but is incomplete and shows insufficient clarity. Additionally, the description of awake bruxism behaviors is confusing. In the background section, these behaviors are ... Continue reading READ ALL In the abstract, I can identify some deficiencies in the study. The second sentence begins with "To" but is incomplete and shows insufficient clarity. Additionally, the description of awake bruxism behaviors is confusing. In the background section, these behaviors are defined in one way, but in the results, they are labeled differently, and in the conclusion, yet another set of names is used. This inconsistency makes it unclear which behavior is being discussed. I have never encountered the term "jaw effort" in the context of awake bruxism. In physiology, "jaw effort" is distinctly defined as "jaw bracing" or "jaw clenching." Jaw effort refers to the amount of force or muscular activity required to perform a specific task, such as chewing, which involves dynamic jaw movements during repetitive actions. In contrast, jaw bracing refers to the often subconscious contraction of the jaw muscles, typically involving sustained tension. The way this was described raises concerns that participants may have been given instructions that led them to misreport their behaviors. In the introduction, the study by Souza does not specifically state that individuals with awake bruxism are at risk for suicidal delusions. In fact, Souza's study is unique in the field and lacks further evidence to support such claims, so this cannot be presented as a fact, nor can the other risk factors. Additionally, the phrase "when comparing populations" is vague—what populations are being compared? Furthermore, in the introduction, the authors mention instrumental approaches such as PDG and EMG, but these concepts are discussed separately. They should be consolidated since they pertain to the same topic. I also noticed that there is no mention in the introduction of the significance of returning to classes or why this is an important moment to assess students’ frequency of awake bruxism. The rationale for assessing relaxation versus non-relaxation is not well explained. I strongly recommend reviewing other articles on EMA and awake bruxism, where the behaviors are more clearly described, as the explanation in the methods section is quite confusing. The methods section needs to be better detailed to align with the results being presented. In the results section, a condition called "daytime pressure" is suddenly introduced, though it was not mentioned previously in the methods, along with other new conditions. The manuscript requires substantial revision, particularly regarding its design, objectives, results, and interpretation. Additionally, the discussion and conclusion need to be more clearly articulated, they are many inconsistencies to allow publishing this article. That said, the authors have done commendable work with a substantial and representative sample. Is the work clearly and accurately presented and does it cite the current literature? Partly Is the study design appropriate and is the work technically sound? No Are sufficient details of methods and analysis provided to allow replication by others? No If applicable, is the statistical analysis and its interpretation appropriate? Partly Are all the source data underlying the results available to ensure full reproducibility? No Are the conclusions drawn adequately supported by the results? No Competing Interests: No competing interests were disclosed. Reviewer Expertise: My research area are: Temporomandibular disorders, bruxism, ecological momentary assessment, fatigue, chewing performance and quantitative sensory testing. I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Medina D. Reviewer Report For: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.5256/f1000research.168484.r328132 ) The direct URL for this report is: https://f1000research.com/articles/12-766/v2#referee-response-328132 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: B V S and Sulaya k. Reviewer Report For: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.5256/f1000research.168484.r310982 ) The direct URL for this report is: https://f1000research.com/articles/12-766/v2#referee-response-310982 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 07 Oct 2024 Swapna B V , Manipal Academy of Higher Education (Ringgold ID: 76793), Manipal, India kavishma Sulaya , Department of Prosthodontics and Crown& Bridge, Manipal Academy of Higher Education, Manipal, Karnataka, India; Manipal Academy of Higher Education (Ringgold ID: 76793), Manipal, Karnataka, India Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.168484.r310982 I would like to appreciate the efforts made by the authors in considering all the suggestions from the reviewers for improving the manuscript. I have few suggestions 1. Abstract – background of the study still remains ... Continue reading READ ALL I would like to appreciate the efforts made by the authors in considering all the suggestions from the reviewers for improving the manuscript. I have few suggestions 1. Abstract – background of the study still remains unclear, could be re written in better way to improve the readership. 2. Introduction - terminologies like pushes or mandibular reinforcement, additive bruxism, jaw effort is still mentioned, are these terminologies appropriate. 3. Recheck reference number 16, it is not by Dr Alessandro Bracci. 4. The conclusion needs to be elaborated as it is too short. Competing Interests: No competing interests were disclosed. Reviewer Expertise: Prosthodontics We confirm that we have read this submission and believe that we have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however we have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT B V S and Sulaya k. Reviewer Report For: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.5256/f1000research.168484.r310982 ) The direct URL for this report is: https://f1000research.com/articles/12-766/v2#referee-response-310982 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Version 1 VERSION 1 PUBLISHED 30 Jun 2023 Views 0 Cite How to cite this report: B V S and Sulaya k. Reviewer Report For: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.5256/f1000research.146965.r274092 ) The direct URL for this report is: https://f1000research.com/articles/12-766/v1#referee-response-274092 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 22 May 2024 Swapna B V , Manipal Academy of Higher Education (Ringgold ID: 76793), Manipal, India kavishma Sulaya , Department of Prosthodontics and Crown& Bridge, Manipal Academy of Higher Education, Manipal, Karnataka, India; Manipal Academy of Higher Education (Ringgold ID: 76793), Manipal, Karnataka, India Not Approved VIEWS 0 https://doi.org/10.5256/f1000research.146965.r274092 This manuscript aims to evaluate the use of smartphone applications in university students with awake bruxism. Abstract- The background is not clear and needs to be rewritten more meaningfully. Please re-write the aim of the study and ... Continue reading READ ALL This manuscript aims to evaluate the use of smartphone applications in university students with awake bruxism. Abstract- The background is not clear and needs to be rewritten more meaningfully. Please re-write the aim of the study and the conclusion. In introduction, the abbreviation SB is for sleep bruxism, but it is wrongly mentioned. There are other abbreviations that have not been expanded, eg. EMA, GA. Please check whether the use of terminologies like pushes or mandibular reinforcement, additive bruxism is appropriate. The methodology of this study is interesting as the tool used for evaluation is gaining popularity, however the manuscript needs to be improvised and more comprehending to improve the readership. The English language requires lot of corrections and improvement as most of the sentences do not convey the intended meaning to the reader. The reference number 16 cited is not by Dr Alessandro Bracci, about development of the app, It is wrongly cited. Is the app available as free version for download? How did the researcher persuade the respondents to download it? What is the full form of BA, mentioned in discussion? The reference number 24, 25 does not match with information about gender differences. The conclusion should be rewritten as this sentence “Bruxism awake with the app was evaluated, identifying 5 behaviors such as’’ makes no sense. Is the work clearly and accurately presented and does it cite the current literature? No Is the study design appropriate and is the work technically sound? Partly Are sufficient details of methods and analysis provided to allow replication by others? No If applicable, is the statistical analysis and its interpretation appropriate? Partly Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? No Competing Interests: No competing interests were disclosed. Reviewer Expertise: Prosthodontics We confirm that we have read this submission and believe that we have an appropriate level of expertise to state that we do not consider it to be of an acceptable scientific standard, for reasons outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT B V S and Sulaya k. Reviewer Report For: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.5256/f1000research.146965.r274092 ) The direct URL for this report is: https://f1000research.com/articles/12-766/v1#referee-response-274092 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 05 Aug 2024 Byron Velasquez Ron , UDLA, Universidad de Las Americas, Quito, 170523, Ecuador 05 Aug 2024 Author Response Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from ... Continue reading Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from two university centers by using a smartphone app, for consideration by F1000reserach . We confirm that this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere. In this paper was to monitor the frequency of awake bruxism behaviors in dental students by using a smartphone app. We attach the comments of the reviewers and the new manuscript with all the changes made. We believe that this manuscript is appropriate for publication by F1000reserach. Reviewed 1 : Maria Beatriz Duarte Gaviao Please, revised the English language in the Introduction, as commented above. Almost paragraphs need to be rewritten, specially the last one, in which the first sentence does not make sense considering the study design, since the AB was not evaluated before or during the pandemic. Moreover, the aim needs to be better described and conclusion must be in agreement. Please, check if the BruxApp was developed by Dr Alessandro Bracci et al . The reference 16 does not match with this information, as well as the authors of reference 16 did not developed the app, I think. Statistical analysis must be inserted in the end of Methods. Please, explain why the condition of relaxation and non relaxation was associated. Why is this association important? Many paragraphs of the Discussion are results, not characterizing discussion. The Conclusion is not reliable, since stress with parafunctions were not evaluated. Finally, the manuscript needs intense reformulation regarding the design, aim, results and their interpretation, and a more precise discussion and conclusion. Despite this, the authors have performed a good job using an expressive sample. Response to comments from reviewers: English language reviewed Cites references reviewed Introduction totally changed Aim changed The Bracci Team created the app (Siena University) References 16 corrected. Statistical analysis changed the order Relaxation and non-relaxation were associated, the app allows in its monitoring to decipher if the patient is relaxed, in some cases the patient does not accept that he is not relaxed, the monitoring clarifies that on some occasions he may be asymptomatic and therefore does not know the condition. Discussion totally changed Conclusion totally changed Reviewer 2 : Swapna B V This manuscript aims to evaluate the use of smartphone applications in university students with awake bruxism. Abstract- The background is not clear and needs to be rewritten more meaningfully. Please re-write the aim of the study and the conclusion. In introduction, the abbreviation SB is for sleep bruxism, but it is wrongly mentioned. There are other abbreviations that have not been expanded, eg. EMA, GA. Please check whether the use of terminologies like pushes or mandibular reinforcement, additive bruxism is appropriate. The methodology of this study is interesting as the tool used for evaluation is gaining popularity, however the manuscript needs to be improvised and more comprehending to improve the readership. The English language requires lot of corrections and improvement as most of the sentences do not convey the intended meaning to the reader. The reference number 16 cited is not by Dr Alessandro Bracci, about development of the app, It is wrongly cited. Is the app available as free version for download? How did the researcher persuade the respondents to download it? What is the full form of BA, mentioned in discussion? The reference number 24, 25 does not match with information about gender differences. The conclusion should be rewritten as this sentence “Bruxism awake with the app was evaluated, identifying 5 behaviors such as’’ makes no sense. Response to comments from reviewers: Abstract totally changed Aim changed Conclusion totally changed SB corrected Abbreviation reviewed The manuscript is corrected English language reviewed References 16 corrected. For academic purposes the app is free, a letter from the institution must be sent that proves the study to be carried out. The participants were socialized about their ailments, as they did not know the subject and explained to them, the study aroused a lot of interest. BA changed for AB (awake bruxism) References 24,25 reviewed Conclusion totally changed Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from two university centers by using a smartphone app, for consideration by F1000reserach . We confirm that this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere. In this paper was to monitor the frequency of awake bruxism behaviors in dental students by using a smartphone app. We attach the comments of the reviewers and the new manuscript with all the changes made. We believe that this manuscript is appropriate for publication by F1000reserach. Reviewed 1 : Maria Beatriz Duarte Gaviao Please, revised the English language in the Introduction, as commented above. Almost paragraphs need to be rewritten, specially the last one, in which the first sentence does not make sense considering the study design, since the AB was not evaluated before or during the pandemic. Moreover, the aim needs to be better described and conclusion must be in agreement. Please, check if the BruxApp was developed by Dr Alessandro Bracci et al . The reference 16 does not match with this information, as well as the authors of reference 16 did not developed the app, I think. Statistical analysis must be inserted in the end of Methods. Please, explain why the condition of relaxation and non relaxation was associated. Why is this association important? Many paragraphs of the Discussion are results, not characterizing discussion. The Conclusion is not reliable, since stress with parafunctions were not evaluated. Finally, the manuscript needs intense reformulation regarding the design, aim, results and their interpretation, and a more precise discussion and conclusion. Despite this, the authors have performed a good job using an expressive sample. Response to comments from reviewers: English language reviewed Cites references reviewed Introduction totally changed Aim changed The Bracci Team created the app (Siena University) References 16 corrected. Statistical analysis changed the order Relaxation and non-relaxation were associated, the app allows in its monitoring to decipher if the patient is relaxed, in some cases the patient does not accept that he is not relaxed, the monitoring clarifies that on some occasions he may be asymptomatic and therefore does not know the condition. Discussion totally changed Conclusion totally changed Reviewer 2 : Swapna B V This manuscript aims to evaluate the use of smartphone applications in university students with awake bruxism. Abstract- The background is not clear and needs to be rewritten more meaningfully. Please re-write the aim of the study and the conclusion. In introduction, the abbreviation SB is for sleep bruxism, but it is wrongly mentioned. There are other abbreviations that have not been expanded, eg. EMA, GA. Please check whether the use of terminologies like pushes or mandibular reinforcement, additive bruxism is appropriate. The methodology of this study is interesting as the tool used for evaluation is gaining popularity, however the manuscript needs to be improvised and more comprehending to improve the readership. The English language requires lot of corrections and improvement as most of the sentences do not convey the intended meaning to the reader. The reference number 16 cited is not by Dr Alessandro Bracci, about development of the app, It is wrongly cited. Is the app available as free version for download? How did the researcher persuade the respondents to download it? What is the full form of BA, mentioned in discussion? The reference number 24, 25 does not match with information about gender differences. The conclusion should be rewritten as this sentence “Bruxism awake with the app was evaluated, identifying 5 behaviors such as’’ makes no sense. Response to comments from reviewers: Abstract totally changed Aim changed Conclusion totally changed SB corrected Abbreviation reviewed The manuscript is corrected English language reviewed References 16 corrected. For academic purposes the app is free, a letter from the institution must be sent that proves the study to be carried out. The participants were socialized about their ailments, as they did not know the subject and explained to them, the study aroused a lot of interest. BA changed for AB (awake bruxism) References 24,25 reviewed Conclusion totally changed Competing Interests: We have no conflicts of interest to disclose. Close Report a concern Author Response 26 Jun 2024 Byron Velasquez Ron , UDLA, Universidad de Las Americas, Quito, 170523, Ecuador 26 Jun 2024 Author Response Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from ... Continue reading Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from two university centers by using a smartphone app, for consideration by F1000reserach . We confirm that this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere. In this paper was to monitor the frequency of awake bruxism behaviors in dental students by using a smartphone app. We attach the comments of the reviewers and the new manuscript with all the changes made. We believe that this manuscript is appropriate for publication by F1000reserach. Response to comments from reviewers: Reviewer 2 . This manuscript aims to evaluate the use of smartphone applications in university students with awake bruxism. Abstract- The background is not clear and needs to be rewritten more meaningfully. Please re-write the aim of the study and the conclusion. In introduction, the abbreviation SB is for sleep bruxism, but it is wrongly mentioned. There are other abbreviations that have not been expanded, eg. EMA, GA. Please check whether the use of terminologies like pushes or mandibular reinforcement, additive bruxism is appropriate. The methodology of this study is interesting as the tool used for evaluation is gaining popularity, however the manuscript needs to be improvised and more comprehending to improve the readership. The English language requires lot of corrections and improvement as most of the sentences do not convey the intended meaning to the reader. The reference number 16 cited is not by Dr Alessandro Bracci, about development of the app, It is wrongly cited. Is the app available as free version for download? How did the researcher persuade the respondents to download it? What is the full form of BA, mentioned in discussion? The reference number 24, 25 does not match with information about gender differences. The conclusion should be rewritten as this sentence “Bruxism awake with the app was evaluated, identifying 5 behaviors such as’’ makes no sense. Response to comments from reviewers: Abstract totally changed Aim changed Conclusion totally changed SB corrected Abbreviation reviewed The manuscript is corrected English language reviewed References 16 corrected. For academic purposes the app is free, a letter from the institution must be sent that proves the study to be carried out. The participants were socialized about their ailments, as they did not know the subject and explained to them, the study aroused a lot of interest. BA changed for AB (awake bruxism) References 24,25 reviewed Conclusion totally changed Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from two university centers by using a smartphone app, for consideration by F1000reserach . We confirm that this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere. In this paper was to monitor the frequency of awake bruxism behaviors in dental students by using a smartphone app. We attach the comments of the reviewers and the new manuscript with all the changes made. We believe that this manuscript is appropriate for publication by F1000reserach. Response to comments from reviewers: Reviewer 2 . This manuscript aims to evaluate the use of smartphone applications in university students with awake bruxism. Abstract- The background is not clear and needs to be rewritten more meaningfully. Please re-write the aim of the study and the conclusion. In introduction, the abbreviation SB is for sleep bruxism, but it is wrongly mentioned. There are other abbreviations that have not been expanded, eg. EMA, GA. Please check whether the use of terminologies like pushes or mandibular reinforcement, additive bruxism is appropriate. The methodology of this study is interesting as the tool used for evaluation is gaining popularity, however the manuscript needs to be improvised and more comprehending to improve the readership. The English language requires lot of corrections and improvement as most of the sentences do not convey the intended meaning to the reader. The reference number 16 cited is not by Dr Alessandro Bracci, about development of the app, It is wrongly cited. Is the app available as free version for download? How did the researcher persuade the respondents to download it? What is the full form of BA, mentioned in discussion? The reference number 24, 25 does not match with information about gender differences. The conclusion should be rewritten as this sentence “Bruxism awake with the app was evaluated, identifying 5 behaviors such as’’ makes no sense. Response to comments from reviewers: Abstract totally changed Aim changed Conclusion totally changed SB corrected Abbreviation reviewed The manuscript is corrected English language reviewed References 16 corrected. For academic purposes the app is free, a letter from the institution must be sent that proves the study to be carried out. The participants were socialized about their ailments, as they did not know the subject and explained to them, the study aroused a lot of interest. BA changed for AB (awake bruxism) References 24,25 reviewed Conclusion totally changed Competing Interests: We have no conflicts of interest to disclose. Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 05 Aug 2024 Byron Velasquez Ron , UDLA, Universidad de Las Americas, Quito, 170523, Ecuador 05 Aug 2024 Author Response Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from ... Continue reading Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from two university centers by using a smartphone app, for consideration by F1000reserach . We confirm that this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere. In this paper was to monitor the frequency of awake bruxism behaviors in dental students by using a smartphone app. We attach the comments of the reviewers and the new manuscript with all the changes made. We believe that this manuscript is appropriate for publication by F1000reserach. Reviewed 1 : Maria Beatriz Duarte Gaviao Please, revised the English language in the Introduction, as commented above. Almost paragraphs need to be rewritten, specially the last one, in which the first sentence does not make sense considering the study design, since the AB was not evaluated before or during the pandemic. Moreover, the aim needs to be better described and conclusion must be in agreement. Please, check if the BruxApp was developed by Dr Alessandro Bracci et al . The reference 16 does not match with this information, as well as the authors of reference 16 did not developed the app, I think. Statistical analysis must be inserted in the end of Methods. Please, explain why the condition of relaxation and non relaxation was associated. Why is this association important? Many paragraphs of the Discussion are results, not characterizing discussion. The Conclusion is not reliable, since stress with parafunctions were not evaluated. Finally, the manuscript needs intense reformulation regarding the design, aim, results and their interpretation, and a more precise discussion and conclusion. Despite this, the authors have performed a good job using an expressive sample. Response to comments from reviewers: English language reviewed Cites references reviewed Introduction totally changed Aim changed The Bracci Team created the app (Siena University) References 16 corrected. Statistical analysis changed the order Relaxation and non-relaxation were associated, the app allows in its monitoring to decipher if the patient is relaxed, in some cases the patient does not accept that he is not relaxed, the monitoring clarifies that on some occasions he may be asymptomatic and therefore does not know the condition. Discussion totally changed Conclusion totally changed Reviewer 2 : Swapna B V This manuscript aims to evaluate the use of smartphone applications in university students with awake bruxism. Abstract- The background is not clear and needs to be rewritten more meaningfully. Please re-write the aim of the study and the conclusion. In introduction, the abbreviation SB is for sleep bruxism, but it is wrongly mentioned. There are other abbreviations that have not been expanded, eg. EMA, GA. Please check whether the use of terminologies like pushes or mandibular reinforcement, additive bruxism is appropriate. The methodology of this study is interesting as the tool used for evaluation is gaining popularity, however the manuscript needs to be improvised and more comprehending to improve the readership. The English language requires lot of corrections and improvement as most of the sentences do not convey the intended meaning to the reader. The reference number 16 cited is not by Dr Alessandro Bracci, about development of the app, It is wrongly cited. Is the app available as free version for download? How did the researcher persuade the respondents to download it? What is the full form of BA, mentioned in discussion? The reference number 24, 25 does not match with information about gender differences. The conclusion should be rewritten as this sentence “Bruxism awake with the app was evaluated, identifying 5 behaviors such as’’ makes no sense. Response to comments from reviewers: Abstract totally changed Aim changed Conclusion totally changed SB corrected Abbreviation reviewed The manuscript is corrected English language reviewed References 16 corrected. For academic purposes the app is free, a letter from the institution must be sent that proves the study to be carried out. The participants were socialized about their ailments, as they did not know the subject and explained to them, the study aroused a lot of interest. BA changed for AB (awake bruxism) References 24,25 reviewed Conclusion totally changed Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from two university centers by using a smartphone app, for consideration by F1000reserach . We confirm that this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere. In this paper was to monitor the frequency of awake bruxism behaviors in dental students by using a smartphone app. We attach the comments of the reviewers and the new manuscript with all the changes made. We believe that this manuscript is appropriate for publication by F1000reserach. Reviewed 1 : Maria Beatriz Duarte Gaviao Please, revised the English language in the Introduction, as commented above. Almost paragraphs need to be rewritten, specially the last one, in which the first sentence does not make sense considering the study design, since the AB was not evaluated before or during the pandemic. Moreover, the aim needs to be better described and conclusion must be in agreement. Please, check if the BruxApp was developed by Dr Alessandro Bracci et al . The reference 16 does not match with this information, as well as the authors of reference 16 did not developed the app, I think. Statistical analysis must be inserted in the end of Methods. Please, explain why the condition of relaxation and non relaxation was associated. Why is this association important? Many paragraphs of the Discussion are results, not characterizing discussion. The Conclusion is not reliable, since stress with parafunctions were not evaluated. Finally, the manuscript needs intense reformulation regarding the design, aim, results and their interpretation, and a more precise discussion and conclusion. Despite this, the authors have performed a good job using an expressive sample. Response to comments from reviewers: English language reviewed Cites references reviewed Introduction totally changed Aim changed The Bracci Team created the app (Siena University) References 16 corrected. Statistical analysis changed the order Relaxation and non-relaxation were associated, the app allows in its monitoring to decipher if the patient is relaxed, in some cases the patient does not accept that he is not relaxed, the monitoring clarifies that on some occasions he may be asymptomatic and therefore does not know the condition. Discussion totally changed Conclusion totally changed Reviewer 2 : Swapna B V This manuscript aims to evaluate the use of smartphone applications in university students with awake bruxism. Abstract- The background is not clear and needs to be rewritten more meaningfully. Please re-write the aim of the study and the conclusion. In introduction, the abbreviation SB is for sleep bruxism, but it is wrongly mentioned. There are other abbreviations that have not been expanded, eg. EMA, GA. Please check whether the use of terminologies like pushes or mandibular reinforcement, additive bruxism is appropriate. The methodology of this study is interesting as the tool used for evaluation is gaining popularity, however the manuscript needs to be improvised and more comprehending to improve the readership. The English language requires lot of corrections and improvement as most of the sentences do not convey the intended meaning to the reader. The reference number 16 cited is not by Dr Alessandro Bracci, about development of the app, It is wrongly cited. Is the app available as free version for download? How did the researcher persuade the respondents to download it? What is the full form of BA, mentioned in discussion? The reference number 24, 25 does not match with information about gender differences. The conclusion should be rewritten as this sentence “Bruxism awake with the app was evaluated, identifying 5 behaviors such as’’ makes no sense. Response to comments from reviewers: Abstract totally changed Aim changed Conclusion totally changed SB corrected Abbreviation reviewed The manuscript is corrected English language reviewed References 16 corrected. For academic purposes the app is free, a letter from the institution must be sent that proves the study to be carried out. The participants were socialized about their ailments, as they did not know the subject and explained to them, the study aroused a lot of interest. BA changed for AB (awake bruxism) References 24,25 reviewed Conclusion totally changed Competing Interests: We have no conflicts of interest to disclose. Close Report a concern Author Response 26 Jun 2024 Byron Velasquez Ron , UDLA, Universidad de Las Americas, Quito, 170523, Ecuador 26 Jun 2024 Author Response Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from ... Continue reading Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from two university centers by using a smartphone app, for consideration by F1000reserach . We confirm that this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere. In this paper was to monitor the frequency of awake bruxism behaviors in dental students by using a smartphone app. We attach the comments of the reviewers and the new manuscript with all the changes made. We believe that this manuscript is appropriate for publication by F1000reserach. Response to comments from reviewers: Reviewer 2 . This manuscript aims to evaluate the use of smartphone applications in university students with awake bruxism. Abstract- The background is not clear and needs to be rewritten more meaningfully. Please re-write the aim of the study and the conclusion. In introduction, the abbreviation SB is for sleep bruxism, but it is wrongly mentioned. There are other abbreviations that have not been expanded, eg. EMA, GA. Please check whether the use of terminologies like pushes or mandibular reinforcement, additive bruxism is appropriate. The methodology of this study is interesting as the tool used for evaluation is gaining popularity, however the manuscript needs to be improvised and more comprehending to improve the readership. The English language requires lot of corrections and improvement as most of the sentences do not convey the intended meaning to the reader. The reference number 16 cited is not by Dr Alessandro Bracci, about development of the app, It is wrongly cited. Is the app available as free version for download? How did the researcher persuade the respondents to download it? What is the full form of BA, mentioned in discussion? The reference number 24, 25 does not match with information about gender differences. The conclusion should be rewritten as this sentence “Bruxism awake with the app was evaluated, identifying 5 behaviors such as’’ makes no sense. Response to comments from reviewers: Abstract totally changed Aim changed Conclusion totally changed SB corrected Abbreviation reviewed The manuscript is corrected English language reviewed References 16 corrected. For academic purposes the app is free, a letter from the institution must be sent that proves the study to be carried out. The participants were socialized about their ailments, as they did not know the subject and explained to them, the study aroused a lot of interest. BA changed for AB (awake bruxism) References 24,25 reviewed Conclusion totally changed Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from two university centers by using a smartphone app, for consideration by F1000reserach . We confirm that this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere. In this paper was to monitor the frequency of awake bruxism behaviors in dental students by using a smartphone app. We attach the comments of the reviewers and the new manuscript with all the changes made. We believe that this manuscript is appropriate for publication by F1000reserach. Response to comments from reviewers: Reviewer 2 . This manuscript aims to evaluate the use of smartphone applications in university students with awake bruxism. Abstract- The background is not clear and needs to be rewritten more meaningfully. Please re-write the aim of the study and the conclusion. In introduction, the abbreviation SB is for sleep bruxism, but it is wrongly mentioned. There are other abbreviations that have not been expanded, eg. EMA, GA. Please check whether the use of terminologies like pushes or mandibular reinforcement, additive bruxism is appropriate. The methodology of this study is interesting as the tool used for evaluation is gaining popularity, however the manuscript needs to be improvised and more comprehending to improve the readership. The English language requires lot of corrections and improvement as most of the sentences do not convey the intended meaning to the reader. The reference number 16 cited is not by Dr Alessandro Bracci, about development of the app, It is wrongly cited. Is the app available as free version for download? How did the researcher persuade the respondents to download it? What is the full form of BA, mentioned in discussion? The reference number 24, 25 does not match with information about gender differences. The conclusion should be rewritten as this sentence “Bruxism awake with the app was evaluated, identifying 5 behaviors such as’’ makes no sense. Response to comments from reviewers: Abstract totally changed Aim changed Conclusion totally changed SB corrected Abbreviation reviewed The manuscript is corrected English language reviewed References 16 corrected. For academic purposes the app is free, a letter from the institution must be sent that proves the study to be carried out. The participants were socialized about their ailments, as they did not know the subject and explained to them, the study aroused a lot of interest. BA changed for AB (awake bruxism) References 24,25 reviewed Conclusion totally changed Competing Interests: We have no conflicts of interest to disclose. Close Report a concern COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Shopova DA. Reviewer Report For: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.5256/f1000research.146965.r224191 ) The direct URL for this report is: https://f1000research.com/articles/12-766/v1#referee-response-224191 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 14 May 2024 Dobromira Antonova Shopova , Department of Prosthetic Dentistry, Faculty of Dental Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria Approved VIEWS 0 https://doi.org/10.5256/f1000research.146965.r224191 The work is clearly and accurately presented and it cites the current literature properly. The study design is appropriate and the work is with technically and scientifically sound. The sufficient details of methods and analysis provide to allow ... Continue reading READ ALL The work is clearly and accurately presented and it cites the current literature properly. The study design is appropriate and the work is with technically and scientifically sound. The sufficient details of methods and analysis provide to allow replication by other researchers. The statistical analysis and its interpretation are appropriate. All the source data underlying the results are available to ensure full reproducibility. The conclusions are adequately drawn and supported by the results. 1. The introduction is short, with only 17 cited authors. In general, the number of references is not large - 50, which tends to the minimum for a review article. I ask the authors to add more articles, especially those published in the last 5 years. Authors can add and more similar articles to enrich their article. 50 cited articles are too small number. 2. Long tables make the results quite difficult. Try to systematize the cited authors more tightly. 3. The discussion is voluminous enough and a sufficient number of authors are compared. 4. The conclusion consists of one short sentence. Authors can submit their opinion on the most suitable app according to them. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: I am a prosthodontics.I am interested in digital technologies in dentistry - additive manufacturing and milling CAD/CAM. I also started working in the field of implantology. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Shopova DA. Reviewer Report For: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.5256/f1000research.146965.r224191 ) The direct URL for this report is: https://f1000research.com/articles/12-766/v1#referee-response-224191 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Gaviao MBD. Reviewer Report For: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.5256/f1000research.146965.r224184 ) The direct URL for this report is: https://f1000research.com/articles/12-766/v1#referee-response-224184 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 14 May 2024 Maria Beatriz Duarte Gaviao , University of Campinas (UNICAMP), Piracicaba, Brazil Not Approved VIEWS 0 https://doi.org/10.5256/f1000research.146965.r224184 This manuscript aimed to evaluate the awake bruxism in university students using a smartphone application. This is an important and interesting issue, the sample is adequate and the authors have looked for a good methodology. Nevertheless, the manuscript needs reworking ... Continue reading READ ALL This manuscript aimed to evaluate the awake bruxism in university students using a smartphone application. This is an important and interesting issue, the sample is adequate and the authors have looked for a good methodology. Nevertheless, the manuscript needs reworking to be more comprehensible. In general, the English language needs to be revised. Furthermore, cited references must be checked for the names of the authors and their respective numbers throughout the text, synchronized with the list of references. Abstract: The “Background” does not make sense. Please, rewrite and defined the aim precisely. Also define the app used, BruxApp app, so as not to confuse the reader. The phrase “Awake bruxism was evaluated with the creation of an app that according to the authors evaluates…” it seems that the authors of this manuscript created the app. It is not possible to understand what additive bruxism is. The conclusion repeats the results and is vague. Text Please, revised the English language in the Introduction, as commented above. Almost paragraphs need to be rewritten, specially the last one, in which the first sentence does not make sense considering the study design, since the AB was not evaluated before or during the pandemic. Moreover, the aim needs to be better described and conclusion must be in agreement. Please, check if the BruxApp was developed by Dr Alessandro Bracci et al . The reference 16 does not match with this information, as well as the authors of reference 16 did not developed the app, I think. Statistical analysis must be inserted in the end of Methods. Please, explain why the condition of relaxation and nonrelaxation was associated. Why is this association important? Many paragraphs of the Discussion are results, not characterizing discussion. The Conclusion is not reliable, since stress with parafunctions were not evaluated. Finally, the manuscript needs intense reformulation regarding the design, aim, results and their interpretation, and a more precise discussion and conclusion. Despite this, the authors have performed a good job using an expressive sample. Is the work clearly and accurately presented and does it cite the current literature? No Is the study design appropriate and is the work technically sound? No Are sufficient details of methods and analysis provided to allow replication by others? No If applicable, is the statistical analysis and its interpretation appropriate? No Are all the source data underlying the results available to ensure full reproducibility? No Are the conclusions drawn adequately supported by the results? No Competing Interests: No competing interests were disclosed. Reviewer Expertise: Oral Physiology, Temporomandibular disorders, Brruxism, Quality of life. I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Gaviao MBD. Reviewer Report For: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.5256/f1000research.146965.r224184 ) The direct URL for this report is: https://f1000research.com/articles/12-766/v1#referee-response-224184 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 05 Aug 2024 Byron Velasquez Ron , UDLA, Universidad de Las Americas, Quito, 170523, Ecuador 05 Aug 2024 Author Response Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from ... Continue reading Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from two university centers by using a smartphone app, for consideration by F1000reserach . We confirm that this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere. In this paper was to monitor the frequency of awake bruxism behaviors in dental students by using a smartphone app. We attach the comments of the reviewers and the new manuscript with all the changes made. We believe that this manuscript is appropriate for publication by F1000reserach. Reviewed 1 : Maria Beatriz Duarte Gaviao Please, revised the English language in the Introduction, as commented above. Almost paragraphs need to be rewritten, specially the last one, in which the first sentence does not make sense considering the study design, since the AB was not evaluated before or during the pandemic. Moreover, the aim needs to be better described and conclusion must be in agreement. Please, check if the BruxApp was developed by Dr Alessandro Bracci et al . The reference 16 does not match with this information, as well as the authors of reference 16 did not developed the app, I think. Statistical analysis must be inserted in the end of Methods. Please, explain why the condition of relaxation and non relaxation was associated. Why is this association important? Many paragraphs of the Discussion are results, not characterizing discussion. The Conclusion is not reliable, since stress with parafunctions were not evaluated. Finally, the manuscript needs intense reformulation regarding the design, aim, results and their interpretation, and a more precise discussion and conclusion. Despite this, the authors have performed a good job using an expressive sample. Response to comments from reviewers: English language reviewed Cites references reviewed Introduction totally changed Aim changed The Bracci Team created the app (Siena University) References 16 corrected. Statistical analysis changed the order Relaxation and non-relaxation were associated, the app allows in its monitoring to decipher if the patient is relaxed, in some cases the patient does not accept that he is not relaxed, the monitoring clarifies that on some occasions he may be asymptomatic and therefore does not know the condition. Discussion totally changed Conclusion totally changed Reviewer 2 : Swapna B V This manuscript aims to evaluate the use of smartphone applications in university students with awake bruxism. Abstract- The background is not clear and needs to be rewritten more meaningfully. Please re-write the aim of the study and the conclusion. In introduction, the abbreviation SB is for sleep bruxism, but it is wrongly mentioned. There are other abbreviations that have not been expanded, eg. EMA, GA. Please check whether the use of terminologies like pushes or mandibular reinforcement, additive bruxism is appropriate. The methodology of this study is interesting as the tool used for evaluation is gaining popularity, however the manuscript needs to be improvised and more comprehending to improve the readership. The English language requires lot of corrections and improvement as most of the sentences do not convey the intended meaning to the reader. The reference number 16 cited is not by Dr Alessandro Bracci, about development of the app, It is wrongly cited. Is the app available as free version for download? How did the researcher persuade the respondents to download it? What is the full form of BA, mentioned in discussion? The reference number 24, 25 does not match with information about gender differences. The conclusion should be rewritten as this sentence “Bruxism awake with the app was evaluated, identifying 5 behaviors such as’’ makes no sense. Response to comments from reviewers: Abstract totally changed Aim changed Conclusion totally changed SB corrected Abbreviation reviewed The manuscript is corrected English language reviewed References 16 corrected. For academic purposes the app is free, a letter from the institution must be sent that proves the study to be carried out. The participants were socialized about their ailments, as they did not know the subject and explained to them, the study aroused a lot of interest. BA changed for AB (awake bruxism) References 24,25 reviewed Conclusion totally changed Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from two university centers by using a smartphone app, for consideration by F1000reserach . We confirm that this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere. In this paper was to monitor the frequency of awake bruxism behaviors in dental students by using a smartphone app. We attach the comments of the reviewers and the new manuscript with all the changes made. We believe that this manuscript is appropriate for publication by F1000reserach. Reviewed 1 : Maria Beatriz Duarte Gaviao Please, revised the English language in the Introduction, as commented above. Almost paragraphs need to be rewritten, specially the last one, in which the first sentence does not make sense considering the study design, since the AB was not evaluated before or during the pandemic. Moreover, the aim needs to be better described and conclusion must be in agreement. Please, check if the BruxApp was developed by Dr Alessandro Bracci et al . The reference 16 does not match with this information, as well as the authors of reference 16 did not developed the app, I think. Statistical analysis must be inserted in the end of Methods. Please, explain why the condition of relaxation and non relaxation was associated. Why is this association important? Many paragraphs of the Discussion are results, not characterizing discussion. The Conclusion is not reliable, since stress with parafunctions were not evaluated. Finally, the manuscript needs intense reformulation regarding the design, aim, results and their interpretation, and a more precise discussion and conclusion. Despite this, the authors have performed a good job using an expressive sample. Response to comments from reviewers: English language reviewed Cites references reviewed Introduction totally changed Aim changed The Bracci Team created the app (Siena University) References 16 corrected. Statistical analysis changed the order Relaxation and non-relaxation were associated, the app allows in its monitoring to decipher if the patient is relaxed, in some cases the patient does not accept that he is not relaxed, the monitoring clarifies that on some occasions he may be asymptomatic and therefore does not know the condition. Discussion totally changed Conclusion totally changed Reviewer 2 : Swapna B V This manuscript aims to evaluate the use of smartphone applications in university students with awake bruxism. Abstract- The background is not clear and needs to be rewritten more meaningfully. Please re-write the aim of the study and the conclusion. In introduction, the abbreviation SB is for sleep bruxism, but it is wrongly mentioned. There are other abbreviations that have not been expanded, eg. EMA, GA. Please check whether the use of terminologies like pushes or mandibular reinforcement, additive bruxism is appropriate. The methodology of this study is interesting as the tool used for evaluation is gaining popularity, however the manuscript needs to be improvised and more comprehending to improve the readership. The English language requires lot of corrections and improvement as most of the sentences do not convey the intended meaning to the reader. The reference number 16 cited is not by Dr Alessandro Bracci, about development of the app, It is wrongly cited. Is the app available as free version for download? How did the researcher persuade the respondents to download it? What is the full form of BA, mentioned in discussion? The reference number 24, 25 does not match with information about gender differences. The conclusion should be rewritten as this sentence “Bruxism awake with the app was evaluated, identifying 5 behaviors such as’’ makes no sense. Response to comments from reviewers: Abstract totally changed Aim changed Conclusion totally changed SB corrected Abbreviation reviewed The manuscript is corrected English language reviewed References 16 corrected. For academic purposes the app is free, a letter from the institution must be sent that proves the study to be carried out. The participants were socialized about their ailments, as they did not know the subject and explained to them, the study aroused a lot of interest. BA changed for AB (awake bruxism) References 24,25 reviewed Conclusion totally changed Competing Interests: We have no conflicts of interest to disclose. Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 05 Aug 2024 Byron Velasquez Ron , UDLA, Universidad de Las Americas, Quito, 170523, Ecuador 05 Aug 2024 Author Response Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from ... Continue reading Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from two university centers by using a smartphone app, for consideration by F1000reserach . We confirm that this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere. In this paper was to monitor the frequency of awake bruxism behaviors in dental students by using a smartphone app. We attach the comments of the reviewers and the new manuscript with all the changes made. We believe that this manuscript is appropriate for publication by F1000reserach. Reviewed 1 : Maria Beatriz Duarte Gaviao Please, revised the English language in the Introduction, as commented above. Almost paragraphs need to be rewritten, specially the last one, in which the first sentence does not make sense considering the study design, since the AB was not evaluated before or during the pandemic. Moreover, the aim needs to be better described and conclusion must be in agreement. Please, check if the BruxApp was developed by Dr Alessandro Bracci et al . The reference 16 does not match with this information, as well as the authors of reference 16 did not developed the app, I think. Statistical analysis must be inserted in the end of Methods. Please, explain why the condition of relaxation and non relaxation was associated. Why is this association important? Many paragraphs of the Discussion are results, not characterizing discussion. The Conclusion is not reliable, since stress with parafunctions were not evaluated. Finally, the manuscript needs intense reformulation regarding the design, aim, results and their interpretation, and a more precise discussion and conclusion. Despite this, the authors have performed a good job using an expressive sample. Response to comments from reviewers: English language reviewed Cites references reviewed Introduction totally changed Aim changed The Bracci Team created the app (Siena University) References 16 corrected. Statistical analysis changed the order Relaxation and non-relaxation were associated, the app allows in its monitoring to decipher if the patient is relaxed, in some cases the patient does not accept that he is not relaxed, the monitoring clarifies that on some occasions he may be asymptomatic and therefore does not know the condition. Discussion totally changed Conclusion totally changed Reviewer 2 : Swapna B V This manuscript aims to evaluate the use of smartphone applications in university students with awake bruxism. Abstract- The background is not clear and needs to be rewritten more meaningfully. Please re-write the aim of the study and the conclusion. In introduction, the abbreviation SB is for sleep bruxism, but it is wrongly mentioned. There are other abbreviations that have not been expanded, eg. EMA, GA. Please check whether the use of terminologies like pushes or mandibular reinforcement, additive bruxism is appropriate. The methodology of this study is interesting as the tool used for evaluation is gaining popularity, however the manuscript needs to be improvised and more comprehending to improve the readership. The English language requires lot of corrections and improvement as most of the sentences do not convey the intended meaning to the reader. The reference number 16 cited is not by Dr Alessandro Bracci, about development of the app, It is wrongly cited. Is the app available as free version for download? How did the researcher persuade the respondents to download it? What is the full form of BA, mentioned in discussion? The reference number 24, 25 does not match with information about gender differences. The conclusion should be rewritten as this sentence “Bruxism awake with the app was evaluated, identifying 5 behaviors such as’’ makes no sense. Response to comments from reviewers: Abstract totally changed Aim changed Conclusion totally changed SB corrected Abbreviation reviewed The manuscript is corrected English language reviewed References 16 corrected. For academic purposes the app is free, a letter from the institution must be sent that proves the study to be carried out. The participants were socialized about their ailments, as they did not know the subject and explained to them, the study aroused a lot of interest. BA changed for AB (awake bruxism) References 24,25 reviewed Conclusion totally changed Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from two university centers by using a smartphone app, for consideration by F1000reserach . We confirm that this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere. In this paper was to monitor the frequency of awake bruxism behaviors in dental students by using a smartphone app. We attach the comments of the reviewers and the new manuscript with all the changes made. We believe that this manuscript is appropriate for publication by F1000reserach. Reviewed 1 : Maria Beatriz Duarte Gaviao Please, revised the English language in the Introduction, as commented above. Almost paragraphs need to be rewritten, specially the last one, in which the first sentence does not make sense considering the study design, since the AB was not evaluated before or during the pandemic. Moreover, the aim needs to be better described and conclusion must be in agreement. Please, check if the BruxApp was developed by Dr Alessandro Bracci et al . The reference 16 does not match with this information, as well as the authors of reference 16 did not developed the app, I think. Statistical analysis must be inserted in the end of Methods. Please, explain why the condition of relaxation and non relaxation was associated. Why is this association important? Many paragraphs of the Discussion are results, not characterizing discussion. The Conclusion is not reliable, since stress with parafunctions were not evaluated. Finally, the manuscript needs intense reformulation regarding the design, aim, results and their interpretation, and a more precise discussion and conclusion. Despite this, the authors have performed a good job using an expressive sample. Response to comments from reviewers: English language reviewed Cites references reviewed Introduction totally changed Aim changed The Bracci Team created the app (Siena University) References 16 corrected. Statistical analysis changed the order Relaxation and non-relaxation were associated, the app allows in its monitoring to decipher if the patient is relaxed, in some cases the patient does not accept that he is not relaxed, the monitoring clarifies that on some occasions he may be asymptomatic and therefore does not know the condition. Discussion totally changed Conclusion totally changed Reviewer 2 : Swapna B V This manuscript aims to evaluate the use of smartphone applications in university students with awake bruxism. Abstract- The background is not clear and needs to be rewritten more meaningfully. Please re-write the aim of the study and the conclusion. In introduction, the abbreviation SB is for sleep bruxism, but it is wrongly mentioned. There are other abbreviations that have not been expanded, eg. EMA, GA. Please check whether the use of terminologies like pushes or mandibular reinforcement, additive bruxism is appropriate. The methodology of this study is interesting as the tool used for evaluation is gaining popularity, however the manuscript needs to be improvised and more comprehending to improve the readership. The English language requires lot of corrections and improvement as most of the sentences do not convey the intended meaning to the reader. The reference number 16 cited is not by Dr Alessandro Bracci, about development of the app, It is wrongly cited. Is the app available as free version for download? How did the researcher persuade the respondents to download it? What is the full form of BA, mentioned in discussion? The reference number 24, 25 does not match with information about gender differences. The conclusion should be rewritten as this sentence “Bruxism awake with the app was evaluated, identifying 5 behaviors such as’’ makes no sense. Response to comments from reviewers: Abstract totally changed Aim changed Conclusion totally changed SB corrected Abbreviation reviewed The manuscript is corrected English language reviewed References 16 corrected. For academic purposes the app is free, a letter from the institution must be sent that proves the study to be carried out. The participants were socialized about their ailments, as they did not know the subject and explained to them, the study aroused a lot of interest. BA changed for AB (awake bruxism) References 24,25 reviewed Conclusion totally changed Competing Interests: We have no conflicts of interest to disclose. Close Report a concern COMMENT ON THIS REPORT Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 30 Jun 2023 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 2 3 4 5 Version 2 (revision) 05 Aug 24 read read read Version 1 30 Jun 23 read read read Maria Beatriz Duarte Gaviao , University of Campinas (UNICAMP), Piracicaba, Brazil Dobromira Antonova Shopova , Medical University of Plovdiv, Plovdiv, Bulgaria Swapna B V , Manipal Academy of Higher Education (Ringgold ID: 76793), Manipal, India kavishma Sulaya , Manipal Academy of Higher Education, Manipal, India; Manipal Academy of Higher Education (Ringgold ID: 76793), Manipal, India Dyanne Medina , University of São Paulo, São Paulo, Brazil Gabriela de Araujo , Universidade Federal de Santa Maria, Santa Maria, Brazil Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 de Araujo G. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 16 Oct 2024 | for Version 2 Gabriela de Araujo , Universidade Federal de Santa Maria, Santa Maria, Brazil 0 Views copyright © 2024 de Araujo G. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Not Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Dear authors, investigating the frequency of behaviors related to awake bruxism, especially in a sample of university students, is important given the increased incidence of this outcome. The topic and idea of the study is relevant, since the use of apps can help change behavior and help identify important signs. However, the study has significant errors in the writing, limiting readers' comprehension on several points. In addition, the shows insufficiency of important information, especially in the study's methodology, could lead to future studies being reproduced. After reading, some aspects could be clarified to improve the article, so please leave your comments below. #Abstract: -The methodology section shows insufficient important information for an initial understanding of the study. How does the app assess the frequency of bruxism? It's not clear how the app identifies the behaviors of tooth contact, muscle relaxation, teeth grinding and the apartment. -Describe the statistical analysis used. #Introduction: - Bruxism has different types of classification depending on how the diagnosis is made. In this case, as the bruxism was self-reported by the student through the app, the most correct term to describe it is “possible bruxism”. Please take care to use the correct term throughout the study. - Please reference the following sentence: “When comparing populations, awake bruxism has risk factors such as mental disorders, depression, and suicidal delusions, among others” - Please describe in the introduction a study from the last five years that has assessed possible awake bruxism in students, and what the associated factors are. The introduction also shows insufficiency data on the prevalence of this condition, especially in relation to the study sample (young students). - Are there any studies that have evaluated bruxism-related apps? If so, please describe. #Methods: - Please include that “possible awake bruxism” was assessed through the participants' self-report; -Important information on data collection is missing. How were participants contacted to take part in the study and download the app? When was the study carried out? Was it after the COVID-19 pandemic? - Why were only university students from recent semesters included? Were only dental students considered? It is not clear here. - Why was there no sample calculation? Especially in descriptive studies, this is unpredictable. I suggest calculating the power of the study. - The statistical analysis part is not very clear. Be careful when relating the chi-square test to the expression “association”. The statistical analysis was carried out to check the distribution of the sample (frequencies) and not associations. #Results: - There are many tables that don't need to exist. I suggest adding the distribution tables for the sex and age variables. I also suggest classifying the age variable categorically (adolescents, young adults and adults) according to the World Health Organization classification. Is the work clearly and accurately presented and does it cite the current literature? Partly Is the study design appropriate and is the work technically sound? No Are sufficient details of methods and analysis provided to allow replication by others? No If applicable, is the statistical analysis and its interpretation appropriate? Partly Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? No Competing Interests No competing interests were disclosed. Reviewer Expertise dentistry; pediatric dentistry; social and preventive dentistry; epidemiology. I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above. reply Respond to this report Responses (0) de Araujo G. Peer Review Report For: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.5256/f1000research.168484.r328134) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/12-766/v2#referee-response-328134 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Medina D. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 11 Oct 2024 | for Version 2 Dyanne Medina , University of São Paulo, São Paulo, Brazil 0 Views copyright © 2024 Medina D. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Not Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions In the abstract, I can identify some deficiencies in the study. The second sentence begins with "To" but is incomplete and shows insufficient clarity. Additionally, the description of awake bruxism behaviors is confusing. In the background section, these behaviors are defined in one way, but in the results, they are labeled differently, and in the conclusion, yet another set of names is used. This inconsistency makes it unclear which behavior is being discussed. I have never encountered the term "jaw effort" in the context of awake bruxism. In physiology, "jaw effort" is distinctly defined as "jaw bracing" or "jaw clenching." Jaw effort refers to the amount of force or muscular activity required to perform a specific task, such as chewing, which involves dynamic jaw movements during repetitive actions. In contrast, jaw bracing refers to the often subconscious contraction of the jaw muscles, typically involving sustained tension. The way this was described raises concerns that participants may have been given instructions that led them to misreport their behaviors. In the introduction, the study by Souza does not specifically state that individuals with awake bruxism are at risk for suicidal delusions. In fact, Souza's study is unique in the field and lacks further evidence to support such claims, so this cannot be presented as a fact, nor can the other risk factors. Additionally, the phrase "when comparing populations" is vague—what populations are being compared? Furthermore, in the introduction, the authors mention instrumental approaches such as PDG and EMG, but these concepts are discussed separately. They should be consolidated since they pertain to the same topic. I also noticed that there is no mention in the introduction of the significance of returning to classes or why this is an important moment to assess students’ frequency of awake bruxism. The rationale for assessing relaxation versus non-relaxation is not well explained. I strongly recommend reviewing other articles on EMA and awake bruxism, where the behaviors are more clearly described, as the explanation in the methods section is quite confusing. The methods section needs to be better detailed to align with the results being presented. In the results section, a condition called "daytime pressure" is suddenly introduced, though it was not mentioned previously in the methods, along with other new conditions. The manuscript requires substantial revision, particularly regarding its design, objectives, results, and interpretation. Additionally, the discussion and conclusion need to be more clearly articulated, they are many inconsistencies to allow publishing this article. That said, the authors have done commendable work with a substantial and representative sample. Is the work clearly and accurately presented and does it cite the current literature? Partly Is the study design appropriate and is the work technically sound? No Are sufficient details of methods and analysis provided to allow replication by others? No If applicable, is the statistical analysis and its interpretation appropriate? Partly Are all the source data underlying the results available to ensure full reproducibility? No Are the conclusions drawn adequately supported by the results? No Competing Interests No competing interests were disclosed. Reviewer Expertise My research area are: Temporomandibular disorders, bruxism, ecological momentary assessment, fatigue, chewing performance and quantitative sensory testing. I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above. reply Respond to this report Responses (0) Medina D. Peer Review Report For: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.5256/f1000research.168484.r328132) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/12-766/v2#referee-response-328132 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 B V S et al. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 07 Oct 2024 | for Version 2 Swapna B V , Manipal Academy of Higher Education (Ringgold ID: 76793), Manipal, India kavishma Sulaya , Department of Prosthodontics and Crown& Bridge, Manipal Academy of Higher Education, Manipal, Karnataka, India; Manipal Academy of Higher Education (Ringgold ID: 76793), Manipal, Karnataka, India 0 Views copyright © 2024 B V S et al. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions I would like to appreciate the efforts made by the authors in considering all the suggestions from the reviewers for improving the manuscript. I have few suggestions 1. Abstract – background of the study still remains unclear, could be re written in better way to improve the readership. 2. Introduction - terminologies like pushes or mandibular reinforcement, additive bruxism, jaw effort is still mentioned, are these terminologies appropriate. 3. Recheck reference number 16, it is not by Dr Alessandro Bracci. 4. The conclusion needs to be elaborated as it is too short. Competing Interests No competing interests were disclosed. Reviewer Expertise Prosthodontics We confirm that we have read this submission and believe that we have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however we have significant reservations, as outlined above. reply Respond to this report Responses (0) B V S and Sulaya k. Peer Review Report For: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.5256/f1000research.168484.r310982) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/12-766/v2#referee-response-310982 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 B V S et al. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 22 May 2024 | for Version 1 Swapna B V , Manipal Academy of Higher Education (Ringgold ID: 76793), Manipal, India kavishma Sulaya , Department of Prosthodontics and Crown& Bridge, Manipal Academy of Higher Education, Manipal, Karnataka, India; Manipal Academy of Higher Education (Ringgold ID: 76793), Manipal, Karnataka, India 0 Views copyright © 2024 B V S et al. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (2) Not Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions This manuscript aims to evaluate the use of smartphone applications in university students with awake bruxism. Abstract- The background is not clear and needs to be rewritten more meaningfully. Please re-write the aim of the study and the conclusion. In introduction, the abbreviation SB is for sleep bruxism, but it is wrongly mentioned. There are other abbreviations that have not been expanded, eg. EMA, GA. Please check whether the use of terminologies like pushes or mandibular reinforcement, additive bruxism is appropriate. The methodology of this study is interesting as the tool used for evaluation is gaining popularity, however the manuscript needs to be improvised and more comprehending to improve the readership. The English language requires lot of corrections and improvement as most of the sentences do not convey the intended meaning to the reader. The reference number 16 cited is not by Dr Alessandro Bracci, about development of the app, It is wrongly cited. Is the app available as free version for download? How did the researcher persuade the respondents to download it? What is the full form of BA, mentioned in discussion? The reference number 24, 25 does not match with information about gender differences. The conclusion should be rewritten as this sentence “Bruxism awake with the app was evaluated, identifying 5 behaviors such as’’ makes no sense. Is the work clearly and accurately presented and does it cite the current literature? No Is the study design appropriate and is the work technically sound? Partly Are sufficient details of methods and analysis provided to allow replication by others? No If applicable, is the statistical analysis and its interpretation appropriate? Partly Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? No Competing Interests No competing interests were disclosed. Reviewer Expertise Prosthodontics We confirm that we have read this submission and believe that we have an appropriate level of expertise to state that we do not consider it to be of an acceptable scientific standard, for reasons outlined above. reply Respond to this report Responses (2) Author Response 05 Aug 2024 Byron Velasquez Ron, UDLA, Universidad de Las Americas, Quito, 170523, Ecuador Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from two university centers by using a smartphone app, for consideration by F1000reserach . We confirm that this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere. In this paper was to monitor the frequency of awake bruxism behaviors in dental students by using a smartphone app. We attach the comments of the reviewers and the new manuscript with all the changes made. We believe that this manuscript is appropriate for publication by F1000reserach. Reviewed 1 : Maria Beatriz Duarte Gaviao Please, revised the English language in the Introduction, as commented above. Almost paragraphs need to be rewritten, specially the last one, in which the first sentence does not make sense considering the study design, since the AB was not evaluated before or during the pandemic. Moreover, the aim needs to be better described and conclusion must be in agreement. Please, check if the BruxApp was developed by Dr Alessandro Bracci et al . The reference 16 does not match with this information, as well as the authors of reference 16 did not developed the app, I think. Statistical analysis must be inserted in the end of Methods. Please, explain why the condition of relaxation and non relaxation was associated. Why is this association important? Many paragraphs of the Discussion are results, not characterizing discussion. The Conclusion is not reliable, since stress with parafunctions were not evaluated. Finally, the manuscript needs intense reformulation regarding the design, aim, results and their interpretation, and a more precise discussion and conclusion. Despite this, the authors have performed a good job using an expressive sample. Response to comments from reviewers: English language reviewed Cites references reviewed Introduction totally changed Aim changed The Bracci Team created the app (Siena University) References 16 corrected. Statistical analysis changed the order Relaxation and non-relaxation were associated, the app allows in its monitoring to decipher if the patient is relaxed, in some cases the patient does not accept that he is not relaxed, the monitoring clarifies that on some occasions he may be asymptomatic and therefore does not know the condition. Discussion totally changed Conclusion totally changed Reviewer 2 : Swapna B V This manuscript aims to evaluate the use of smartphone applications in university students with awake bruxism. Abstract- The background is not clear and needs to be rewritten more meaningfully. Please re-write the aim of the study and the conclusion. In introduction, the abbreviation SB is for sleep bruxism, but it is wrongly mentioned. There are other abbreviations that have not been expanded, eg. EMA, GA. Please check whether the use of terminologies like pushes or mandibular reinforcement, additive bruxism is appropriate. The methodology of this study is interesting as the tool used for evaluation is gaining popularity, however the manuscript needs to be improvised and more comprehending to improve the readership. The English language requires lot of corrections and improvement as most of the sentences do not convey the intended meaning to the reader. The reference number 16 cited is not by Dr Alessandro Bracci, about development of the app, It is wrongly cited. Is the app available as free version for download? How did the researcher persuade the respondents to download it? What is the full form of BA, mentioned in discussion? The reference number 24, 25 does not match with information about gender differences. The conclusion should be rewritten as this sentence “Bruxism awake with the app was evaluated, identifying 5 behaviors such as’’ makes no sense. Response to comments from reviewers: Abstract totally changed Aim changed Conclusion totally changed SB corrected Abbreviation reviewed The manuscript is corrected English language reviewed References 16 corrected. For academic purposes the app is free, a letter from the institution must be sent that proves the study to be carried out. The participants were socialized about their ailments, as they did not know the subject and explained to them, the study aroused a lot of interest. BA changed for AB (awake bruxism) References 24,25 reviewed Conclusion totally changed View more View less Competing Interests We have no conflicts of interest to disclose. reply Respond Report a concern Author Response 26 Jun 2024 Byron Velasquez Ron, UDLA, Universidad de Las Americas, Quito, 170523, Ecuador Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from two university centers by using a smartphone app, for consideration by F1000reserach . We confirm that this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere. In this paper was to monitor the frequency of awake bruxism behaviors in dental students by using a smartphone app. We attach the comments of the reviewers and the new manuscript with all the changes made. We believe that this manuscript is appropriate for publication by F1000reserach. Response to comments from reviewers: Reviewer 2 . This manuscript aims to evaluate the use of smartphone applications in university students with awake bruxism. Abstract- The background is not clear and needs to be rewritten more meaningfully. Please re-write the aim of the study and the conclusion. In introduction, the abbreviation SB is for sleep bruxism, but it is wrongly mentioned. There are other abbreviations that have not been expanded, eg. EMA, GA. Please check whether the use of terminologies like pushes or mandibular reinforcement, additive bruxism is appropriate. The methodology of this study is interesting as the tool used for evaluation is gaining popularity, however the manuscript needs to be improvised and more comprehending to improve the readership. The English language requires lot of corrections and improvement as most of the sentences do not convey the intended meaning to the reader. The reference number 16 cited is not by Dr Alessandro Bracci, about development of the app, It is wrongly cited. Is the app available as free version for download? How did the researcher persuade the respondents to download it? What is the full form of BA, mentioned in discussion? The reference number 24, 25 does not match with information about gender differences. The conclusion should be rewritten as this sentence “Bruxism awake with the app was evaluated, identifying 5 behaviors such as’’ makes no sense. Response to comments from reviewers: Abstract totally changed Aim changed Conclusion totally changed SB corrected Abbreviation reviewed The manuscript is corrected English language reviewed References 16 corrected. For academic purposes the app is free, a letter from the institution must be sent that proves the study to be carried out. The participants were socialized about their ailments, as they did not know the subject and explained to them, the study aroused a lot of interest. BA changed for AB (awake bruxism) References 24,25 reviewed Conclusion totally changed View more View less Competing Interests We have no conflicts of interest to disclose. reply Respond Report a concern B V S and Sulaya k. Peer Review Report For: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.5256/f1000research.146965.r274092) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/12-766/v1#referee-response-274092 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Shopova D. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 14 May 2024 | for Version 1 Dobromira Antonova Shopova , Department of Prosthetic Dentistry, Faculty of Dental Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria 0 Views copyright © 2024 Shopova D. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The work is clearly and accurately presented and it cites the current literature properly. The study design is appropriate and the work is with technically and scientifically sound. The sufficient details of methods and analysis provide to allow replication by other researchers. The statistical analysis and its interpretation are appropriate. All the source data underlying the results are available to ensure full reproducibility. The conclusions are adequately drawn and supported by the results. 1. The introduction is short, with only 17 cited authors. In general, the number of references is not large - 50, which tends to the minimum for a review article. I ask the authors to add more articles, especially those published in the last 5 years. Authors can add and more similar articles to enrich their article. 50 cited articles are too small number. 2. Long tables make the results quite difficult. Try to systematize the cited authors more tightly. 3. The discussion is voluminous enough and a sufficient number of authors are compared. 4. The conclusion consists of one short sentence. Authors can submit their opinion on the most suitable app according to them. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes Competing Interests No competing interests were disclosed. Reviewer Expertise I am a prosthodontics.I am interested in digital technologies in dentistry - additive manufacturing and milling CAD/CAM. I also started working in the field of implantology. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Shopova DA. Peer Review Report For: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.5256/f1000research.146965.r224191) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/12-766/v1#referee-response-224191 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Gaviao M. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 14 May 2024 | for Version 1 Maria Beatriz Duarte Gaviao , University of Campinas (UNICAMP), Piracicaba, Brazil 0 Views copyright © 2024 Gaviao M. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (1) Not Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions This manuscript aimed to evaluate the awake bruxism in university students using a smartphone application. This is an important and interesting issue, the sample is adequate and the authors have looked for a good methodology. Nevertheless, the manuscript needs reworking to be more comprehensible. In general, the English language needs to be revised. Furthermore, cited references must be checked for the names of the authors and their respective numbers throughout the text, synchronized with the list of references. Abstract: The “Background” does not make sense. Please, rewrite and defined the aim precisely. Also define the app used, BruxApp app, so as not to confuse the reader. The phrase “Awake bruxism was evaluated with the creation of an app that according to the authors evaluates…” it seems that the authors of this manuscript created the app. It is not possible to understand what additive bruxism is. The conclusion repeats the results and is vague. Text Please, revised the English language in the Introduction, as commented above. Almost paragraphs need to be rewritten, specially the last one, in which the first sentence does not make sense considering the study design, since the AB was not evaluated before or during the pandemic. Moreover, the aim needs to be better described and conclusion must be in agreement. Please, check if the BruxApp was developed by Dr Alessandro Bracci et al . The reference 16 does not match with this information, as well as the authors of reference 16 did not developed the app, I think. Statistical analysis must be inserted in the end of Methods. Please, explain why the condition of relaxation and nonrelaxation was associated. Why is this association important? Many paragraphs of the Discussion are results, not characterizing discussion. The Conclusion is not reliable, since stress with parafunctions were not evaluated. Finally, the manuscript needs intense reformulation regarding the design, aim, results and their interpretation, and a more precise discussion and conclusion. Despite this, the authors have performed a good job using an expressive sample. Is the work clearly and accurately presented and does it cite the current literature? No Is the study design appropriate and is the work technically sound? No Are sufficient details of methods and analysis provided to allow replication by others? No If applicable, is the statistical analysis and its interpretation appropriate? No Are all the source data underlying the results available to ensure full reproducibility? No Are the conclusions drawn adequately supported by the results? No Competing Interests No competing interests were disclosed. Reviewer Expertise Oral Physiology, Temporomandibular disorders, Brruxism, Quality of life. I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above. reply Respond to this report Responses (1) Author Response 05 Aug 2024 Byron Velasquez Ron, UDLA, Universidad de Las Americas, Quito, 170523, Ecuador Dear Mr. Editor, after the corrections recommended by the reviewers and yours, we present an Original Research article entitle Monitoring the frequency of awake bruxism behaviors in dental students from two university centers by using a smartphone app, for consideration by F1000reserach . We confirm that this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere. In this paper was to monitor the frequency of awake bruxism behaviors in dental students by using a smartphone app. We attach the comments of the reviewers and the new manuscript with all the changes made. We believe that this manuscript is appropriate for publication by F1000reserach. Reviewed 1 : Maria Beatriz Duarte Gaviao Please, revised the English language in the Introduction, as commented above. Almost paragraphs need to be rewritten, specially the last one, in which the first sentence does not make sense considering the study design, since the AB was not evaluated before or during the pandemic. Moreover, the aim needs to be better described and conclusion must be in agreement. Please, check if the BruxApp was developed by Dr Alessandro Bracci et al . The reference 16 does not match with this information, as well as the authors of reference 16 did not developed the app, I think. Statistical analysis must be inserted in the end of Methods. Please, explain why the condition of relaxation and non relaxation was associated. Why is this association important? Many paragraphs of the Discussion are results, not characterizing discussion. The Conclusion is not reliable, since stress with parafunctions were not evaluated. Finally, the manuscript needs intense reformulation regarding the design, aim, results and their interpretation, and a more precise discussion and conclusion. Despite this, the authors have performed a good job using an expressive sample. Response to comments from reviewers: English language reviewed Cites references reviewed Introduction totally changed Aim changed The Bracci Team created the app (Siena University) References 16 corrected. Statistical analysis changed the order Relaxation and non-relaxation were associated, the app allows in its monitoring to decipher if the patient is relaxed, in some cases the patient does not accept that he is not relaxed, the monitoring clarifies that on some occasions he may be asymptomatic and therefore does not know the condition. Discussion totally changed Conclusion totally changed Reviewer 2 : Swapna B V This manuscript aims to evaluate the use of smartphone applications in university students with awake bruxism. Abstract- The background is not clear and needs to be rewritten more meaningfully. Please re-write the aim of the study and the conclusion. In introduction, the abbreviation SB is for sleep bruxism, but it is wrongly mentioned. There are other abbreviations that have not been expanded, eg. EMA, GA. Please check whether the use of terminologies like pushes or mandibular reinforcement, additive bruxism is appropriate. The methodology of this study is interesting as the tool used for evaluation is gaining popularity, however the manuscript needs to be improvised and more comprehending to improve the readership. The English language requires lot of corrections and improvement as most of the sentences do not convey the intended meaning to the reader. The reference number 16 cited is not by Dr Alessandro Bracci, about development of the app, It is wrongly cited. Is the app available as free version for download? How did the researcher persuade the respondents to download it? What is the full form of BA, mentioned in discussion? The reference number 24, 25 does not match with information about gender differences. The conclusion should be rewritten as this sentence “Bruxism awake with the app was evaluated, identifying 5 behaviors such as’’ makes no sense. Response to comments from reviewers: Abstract totally changed Aim changed Conclusion totally changed SB corrected Abbreviation reviewed The manuscript is corrected English language reviewed References 16 corrected. For academic purposes the app is free, a letter from the institution must be sent that proves the study to be carried out. The participants were socialized about their ailments, as they did not know the subject and explained to them, the study aroused a lot of interest. BA changed for AB (awake bruxism) References 24,25 reviewed Conclusion totally changed View more View less Competing Interests We have no conflicts of interest to disclose. reply Respond Report a concern Gaviao MBD. Peer Review Report For: Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers [version 2; peer review: 1 approved, 1 approved with reservations, 3 not approved] . F1000Research 2024, 12 :766 ( https://doi.org/10.5256/f1000research.146965.r224184) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/12-766/v1#referee-response-224184 Alongside their report, reviewers assign a status to the article: Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions Adjust parameters to alter display View on desktop for interactive features Includes Interactive Elements View on desktop for interactive features Competing Interests Policy Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. Consider the following examples, but note that this is not an exhaustive list: Examples of 'Non-Financial Competing Interests' Within the past 4 years, you have held joint grants, published or collaborated with any of the authors of the selected paper. You have a close personal relationship (e.g. parent, spouse, sibling, or domestic partner) with any of the authors. You are a close professional associate of any of the authors (e.g. scientific mentor, recent student). You work at the same institute as any of the authors. You hope/expect to benefit (e.g. favour or employment) as a result of your submission. You are an Editor for the journal in which the article is published. Examples of 'Financial Competing Interests' You expect to receive, or in the past 4 years have received, any of the following from any commercial organisation that may gain financially from your submission: a salary, fees, funding, reimbursements. You expect to receive, or in the past 4 years have received, shared grant support or other funding with any of the authors. You hold, or are currently applying for, any patents or significant stocks/shares relating to the subject matter of the paper you are commenting on. Stay Updated Sign up for content alerts and receive a weekly or monthly email with all newly published articles Register with F1000Research Already registered? Sign in Not now, thanks close PLEASE NOTE If you are an AUTHOR of this article, please check that you signed in with the account associated with this article otherwise we cannot automatically identify your role as an author and your comment will be labelled as a “User Comment”. If you are a REVIEWER of this article, please check that you have signed in with the account associated with this article and then go to your account to submit your report, please do not post your review here. If you do not have access to your original account, please contact us . All commenters must hold a formal affiliation as per our Policies . The information that you give us will be displayed next to your comment. User comments must be in English, comprehensible and relevant to the article under discussion. We reserve the right to remove any comments that we consider to be inappropriate, offensive or otherwise in breach of the User Comment Terms and Conditions . Commenters must not use a comment for personal attacks. When criticisms of the article are based on unpublished data, the data should be made available. I accept the User Comment Terms and Conditions Please confirm that you accept the User Comment Terms and Conditions. Affiliation ✕ refresh Please enter your institution. Note: To add your institution or organisation, start typing the name and then select the correct name from the list. Where applicable, the name will appear in both the original language and in English. Do not paste in the name. If the name does not appear in the drop-down list, we will display the information you have entered. ✕ refresh Country/Region * USA UK Canada China France Germany Afghanistan Aland Islands Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory British Virgin Islands Brunei Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Cook Islands Costa Rica Cote d'Ivoire Croatia Cuba Cyprus Czech Republic Democratic Republic of the Congo Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands Faroe Islands Federated States of Micronesia Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guam Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and Mcdonald Islands Holy See (Vatican City State) Honduras Hong Kong Hungary Iceland India Indonesia Iran Iraq Ireland Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Kosovo (Serbia and Montenegro) Kuwait Kyrgyzstan Lao People's Democratic Republic Latvia Lebanon Lesotho Liberia Libya Liechtenstein Lithuania Luxembourg Macao Madagascar Malawi Malaysia Maldives Mali Malta Marshall Islands Martinique Mauritania Mauritius Mayotte Mexico Minor Outlying Islands of the United States Moldova Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands Antilles New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island North Korea North Macedonia Northern Mariana Islands Norway Oman Pakistan Palau Palestinian Territory Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Puerto Rico Qatar Reunion Romania Russian Federation Rwanda Saint Helena Saint Kitts and Nevis Saint Lucia Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Is South Korea South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syria Taiwan Tajikistan Tanzania Thailand The Gambia The Netherlands Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu UK USA Uganda Ukraine United Arab Emirates United States Virgin Islands Uruguay Uzbekistan Vanuatu Venezuela Vietnam Wallis and Futuna West Bank and Gaza Strip Western Sahara Yemen Zambia Zimbabwe Please select your country/region. You must enter a comment. Competing Interests Please disclose any competing interests that might be construed to influence your judgment of the article's or peer review report's validity or importance. Competing Interests Policy Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. Consider the following examples, but note that this is not an exhaustive list: Examples of 'Non-Financial Competing Interests' Within the past 4 years, you have held joint grants, published or collaborated with any of the authors of the selected paper. You have a close personal relationship (e.g. parent, spouse, sibling, or domestic partner) with any of the authors. You are a close professional associate of any of the authors (e.g. scientific mentor, recent student). You work at the same institute as any of the authors. You hope/expect to benefit (e.g. favour or employment) as a result of your submission. You are an Editor for the journal in which the article is published. Examples of 'Financial Competing Interests' You expect to receive, or in the past 4 years have received, any of the following from any commercial organisation that may gain financially from your submission: a salary, fees, funding, reimbursements. You expect to receive, or in the past 4 years have received, shared grant support or other funding with any of the authors. You hold, or are currently applying for, any patents or significant stocks/shares relating to the subject matter of the paper you are commenting on. Please state your competing interests The comment has been saved. An error has occurred. Please try again. Cancel Post var lTitle = "Evaluation by app in smartphones of awake...".replace("'", ''); var linkedInUrl = "http://www.linkedin.com/shareArticle?url=https://f1000research.com/articles/12-766/v2" + "&title=" + encodeURIComponent(lTitle) + "&summary=" + encodeURIComponent('Read the article by '); var deliciousUrl = "https://del.icio.us/post?url=https://f1000research.com/articles/12-766/v2&title=" + encodeURIComponent(lTitle); var redditUrl = "http://reddit.com/submit?url=https://f1000research.com/articles/12-766/v2" + "&title=" + encodeURIComponent(lTitle); linkedInUrl += encodeURIComponent('Velasquez Ron B et al.'); var offsetTop = /chrome/i.test( navigator.userAgent ) ? 4 : -10; var addthis_config = { ui_offset_top: offsetTop, services_compact : "facebook,twitter,www.linkedin.com,www.mendeley.com,reddit.com", services_expanded : "facebook,twitter,www.linkedin.com,www.mendeley.com,reddit.com", services_custom : [ { name: "LinkedIn", url: linkedInUrl, icon:"/img/icon/at_linkedin.svg" }, { name: "Mendeley", url: "http://www.mendeley.com/import/?url=https://f1000research.com/articles/12-766/v2/mendeley", icon:"/img/icon/at_mendeley.svg" }, { name: "Reddit", url: redditUrl, icon:"/img/icon/at_reddit.svg" }, ] }; var addthis_share = { url: "https://f1000research.com/articles/12-766", templates : { twitter : "Evaluation by app in smartphones of awake \u00A0bruxism at the.... Velasquez Ron B et al., published by " + "@F1000Research" + ", https://f1000research.com/articles/12-766/v2" } }; if (typeof(addthis) != "undefined"){ addthis.addEventListener('addthis.ready', checkCount); addthis.addEventListener('addthis.menu.share', checkCount); } $(".f1r-shares-twitter").attr("href", "https://twitter.com/intent/tweet?text=" + addthis_share.templates.twitter); $(".f1r-shares-facebook").attr("href", "https://www.facebook.com/sharer/sharer.php?u=" + addthis_share.url); $(".f1r-shares-linkedin").attr("href", addthis_config.services_custom[0].url); $(".f1r-shares-reddit").attr("href", addthis_config.services_custom[2].url); $(".f1r-shares-mendelay").attr("href", addthis_config.services_custom[1].url); function checkCount(){ setTimeout(function(){ $(".addthis_button_expanded").each(function(){ var count = $(this).text(); if (count !== "" && count != "0") $(this).removeClass("is-hidden"); else $(this).addClass("is-hidden"); }); }, 1000); } close How to cite this report {{reportCitation}} Cancel Copy Citation Details $(function(){R.ui.buttonDropdowns('.dropdown-for-downloads');}); $(function(){R.ui.toolbarDropdowns('.toolbar-dropdown-for-downloads');}); $.get("/articles/acj/133946/168484") new F1000.Clipboard(); new F1000.ThesaurusTermsDisplay("articles", "article", "168484"); $(document).ready(function() { $( "#frame1" ).on('load', function() { var mydiv = $(this).contents().find("div"); var h = mydiv.height(); console.log(h) }); var tooltipLivingFigure = jQuery(".interactive-living-figure-label .icon-more-info"), titleLivingFigure = tooltipLivingFigure.attr("title"); tooltipLivingFigure.simpletip({ fixed: true, position: ["-115", "30"], baseClass: 'small-tooltip', content:titleLivingFigure + " " }); tooltipLivingFigure.removeAttr("title"); $("body").on("click", ".cite-living-figure", function(e) { e.preventDefault(); var ref = $(this).attr("data-ref"); $(this).closest(".living-figure-list-container").find("#" + ref).fadeIn(200); }); $("body").on("click", ".close-cite-living-figure", function(e) { e.preventDefault(); $(this).closest(".popup-window-wrapper").fadeOut(200); }); $(document).on("mouseup", function(e) { var metricsContainer = $(".article-metrics-popover-wrapper"); if (!metricsContainer.is(e.target) && metricsContainer.has(e.target).length === 0) { $(".article-metrics-close-button").click(); } }); var articleId = $('#articleId').val(); if($("#main-article-count-box").attachArticleMetrics) { $("#main-article-count-box").attachArticleMetrics(articleId, { articleMetricsView: true }); } }); var figshareWidget = $(".new_figshare_widget"); if (figshareWidget.length > 0) { window.figshare.load("f1000", function(Widget) { // Select a tag/tags defined in your page. In this tag we will place the widget. _.map(figshareWidget, function(el){ var widget = new Widget({ articleId: $(el).attr("figshare_articleId") //height:300 // this is the height of the viewer part. [Default: 550] }); widget.initialize(); // initialize the widget widget.mount(el); // mount it in a tag that's on your page // this will save the widget on the global scope for later use from // your JS scripts. This line is optional. //window.widget = widget; }); }); } close Error Close Add Reset F1000.MICROSERVICES.AFFILIATION = ''; $(document).ready(function () { $('.js-affiliations-form').each((index, form) => { new AffiliationForm({ formId: form.id, institutionErrorSelector: '.comment-enter-institution', departmentErrorSelector: '.comment-enter-department', placeSelector: '.js-add-comment-place', stateSelector: '.js-add-comment-state', zipCodeSelector: '.js-add-comment-zipcode', countrySelector: '.js-add-comment-country', countryErrorSelector: '.comment-enter-country', }); }); }); $(document).ready(function () { var reportIds = { "321316": 0, "321317": 0, "321318": 0, "321319": 0, "321312": 0, "189734": 0, "321313": 0, "321314": 0, "321315": 0, "189738": 0, "321320": 0, "321321": 0, "189746": 1, "189747": 0, "189745": 0, "189750": 0, "189751": 0, "189748": 0, "189749": 0, "189754": 0, "211029": 0, "211035": 0, "211034": 0, "211033": 0, "211037": 0, "211036": 0, "211040": 0, "211046": 0, "211045": 0, "211051": 0, "324748": 0, "324749": 0, "324750": 0, "324751": 0, "324756": 0, "324757": 0, "324752": 0, "324753": 0, "324754": 0, "324755": 0, "274092": 26, "274093": 0, "274094": 0, "274095": 0, "198319": 0, "198318": 0, "198317": 0, "198316": 0, "274100": 0, "268724": 0, "317621": 0, "198322": 0, "274101": 0, "268725": 0, "317622": 0, "268726": 0, "317623": 0, "198320": 0, "268727": 0, "224183": 0, "274096": 0, "274097": 0, "274098": 0, "224180": 0, "198324": 0, "274099": 0, "268723": 0, "317628": 0, "224187": 0, "268732": 0, "317629": 0, "224186": 0, "317630": 0, "224185": 0, "224184": 22, "317624": 0, "198335": 0, "184766": 0, "268728": 0, "224191": 11, "317625": 0, "198334": 0, "184767": 0, "224190": 0, "268729": 0, "317626": 0, "224189": 0, "268730": 0, "317627": 0, "224188": 0, "198332": 0, "268731": 0, "328133": 0, "310980": 0, "184770": 0, "251331": 0, "310981": 0, "328132": 7, "184771": 0, "328135": 0, "310982": 9, "184768": 0, "328134": 5, "184769": 0, "184774": 0, "184775": 0, "251334": 0, "184772": 0, "251333": 0, "184773": 0, "251332": 0, "328141": 0, "328140": 0, "328137": 0, "328136": 0, "328139": 0, "328138": 0, }; $(".referee-response-container,.js-referee-report").each(function(index, el) { var reportId = $(el).attr("data-reportid"), reportCount = reportIds[reportId] || 0; $(el).find(".comments-count-container,.js-referee-report-views").html(reportCount); }); var uuidInput = $("#article_uuid"), oldUUId = uuidInput.val(), newUUId = "750c10dd-ad31-4fe2-b104-39106ab86376"; uuidInput.val(newUUId); $("a[href*='article_uuid=']").each(function(index, el) { var newHref = $(el).attr("href").replace(oldUUId, newUUId); $(el).attr("href", newHref); }); }); An innovative open access publishing platform offering rapid publication and open peer review, whilst supporting data deposition and sharing. Browse Gateways Collections How it Works Contact For Developers Cookie Notice Privacy Notice RSS Submit Your Research Follow us © 2012-2026 F1000 Research Ltd. ISSN 2046-1402 | Legal | Partner of Research4Life • CrossRef • ORCID • FAIRSharing R.templateTests.simpleTemplate = R.template(' $text $text $text $text $text '); R.templateTests.runTests(); var F1000platform = new F1000.Platform({ name: "f1000research", displayName: "F1000Research", hostName: "f1000research.com", id: "1", editorialEmail: "
[email protected]", infoEmail: "
[email protected]", usePmcStats: true }); $(function(){R.ui.dropdowns('.dropdown-for-authors, .dropdown-for-about, .dropdown-for-myresearch');}); // $(function(){R.ui.dropdowns('.dropdown-for-referees');}); $(document).ready(function () { if ($(".cookie-warning").is(":visible")) { $(".sticky").css("margin-bottom", "35px"); $(".devices").addClass("devices-and-cookie-warning"); } $(".cookie-warning .close-button").click(function (e) { $(".devices").removeClass("devices-and-cookie-warning"); $(".sticky").css("margin-bottom", "0"); }); $("#tweeter-feed .tweet-message").each(function (i, message) { var self = $(message); self.html(linkify(self.html())); }); $(".partner").on("mouseenter mouseleave", function() { $(this).find(".gray-scale, .colour").toggleClass("is-hidden"); }); }); Sign In Remember me Forgotten your password? Sign In Cancel Email or password not correct. Please try again Please wait... $(function(){ // Note: All the setup needs to run against a name attribute and *not* the id due the clonish // nature of facebox... $("a[id=googleSignInButton]").click(function(event){ event.preventDefault(); $("input[id=oAuthSystem]").val("GOOGLE"); $("form[id=oAuthForm]").submit(); }); $("a[id=facebookSignInButton]").click(function(event){ event.preventDefault(); $("input[id=oAuthSystem]").val("FACEBOOK"); $("form[id=oAuthForm]").submit(); }); $("a[id=orcidSignInButton]").click(function(event){ event.preventDefault(); $("input[id=oAuthSystem]").val("ORCID"); $("form[id=oAuthForm]").submit(); }); }); If you've forgotten your password, please enter your email address below and we'll send you instructions on how to reset your password. The email address should be the one you originally registered with F1000. Email address not valid, please try again You registered with F1000 via Google, so we cannot reset your password. To sign in, please click here . If you still need help with your Google account password, please click here . You registered with F1000 via Facebook, so we cannot reset your password. To sign in, please click here . If you still need help with your Facebook account password, please click here . Code not correct, please try again Reset password Cancel Email us for further assistance. Server error, please try again. If your email address is registered with us, we will email you instructions to reset your password. If you think you should have received this email but it has not arrived, please check your spam filters and/or contact for further assistance. Please wait... Register $(document).ready(function () { signIn.createSignInAsRow($("#sign-in-form-gfb-popup")); $(".target-field").each(function () { var uris = $(this).val().split("/"); if (uris.pop() === "login") { $(this).val(uris.toString().replace(",","/")); } }); });
Text is read by the "Ask this paper" AI Q&A widget below.
Extraction quality varies by source — PMC NXML preserves structure
cleanly, OA-HTML may include some navigation residue, and OA-PDF can
have broken hyphenation. The publisher copy
(via DOI)
is the canonical version.