The Role of microRNA 122, MCP-1 and TGF-β1 as Diagnostic Biomarkers for Endometriosis

Ekhlas Saddam Falih, Suhad Hassan Aubaid, Wala'a Taha Yousif
In: Indian Journal of Public Health Research & Development · 2019 · vol. 10(10) , pp. 2652 · doi:10.5958/0976-5506.2019.03267.4 · W2998472243
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This study investigated serum miRNA122, MCP-1, and TGF-β1 in endometriosis patients, finding significantly elevated levels of all three biomarkers compared to controls.

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This 2019 study evaluated serum biomarkers for endometriosis by measuring circulating microRNA 122 (miR-122) using RT-qPCR and assessing MCP-1 and TGF-β1 levels by ELISA in 25 laparotomy-confirmed endometriosis patients and 25 apparently healthy controls. The key finding was that plasma miR-122 levels were markedly higher in patients than in controls (mean log fold change 19.65 vs 3.42, P=0.001), and that MCP-1 and TGF-β1 concentrations were also significantly elevated in endometriosis (P<0.05). The paper’s main limitation is the small sample size and that it does not report diagnostic performance metrics beyond group comparisons. This paper is centrally about endometriosis—specifically, assessing miRNA-122 alongside MCP-1 and TGF-β1 in serum as diagnostic biomarkers.

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- Year: 2019 - Volume: 10 - Issue: 10 - Author: - Ekhlas Saddam Falih1, Suhad Hassan Aubaid1,, Wala'a Taha Yousif1 - Total Page Count: 5 - Page Number: 2652 to 2656 1 *Corresponding Author: Suhad Hassan Aubaid, Endometriosis represents a major medical concern in women of reproductive age. A Reliable single biomarker or panel of biomarkers may help diagnose endometriosis earlier and reduce unnecessary operation. Simple blood tests for prediction and diagnosis of endometriosis have a major impact on women's health. MicroRNAs are small Non-coding RNAs that have been intensively evaluated as biomarkers for several diseases and may hold promise for endometriosis diagnosis. The present study was aimed to explore the possible role of using serum miRNA122 in endometriosis patients to supply a more accurate assessment of the disease and improve the role of other serum biomarkers in endometriosis. Twenty-five endometriosis patients diagnosed by laparotomy were admitted to the Gynecology Department of Al-Emamain Al-Kademian Medical City, Baghdad, Iraq. A total of twenty-five apparently healthy women were chosen as controls. The miR122 was detected by reverse transcription-quantitative polymerase chain reaction (RT qPCR), while the MCP-1 and TGF-β1 were detected by the ELISA technique. This study showed that the mean log fold change value of miR122 in plasma of endometriosis patients, which was (19.65), was higher in comparison to controls (3.42) (P= 0.001). The mean concentrations of MCP-1 and TGF-β1 were significantly higher in patients with endometriosis than in controls (P<0.05). Measurements of serum, miRNA122 may be useful in the evaluation of endometriosis patients in combination with other serum markers. Endometriosis, MicroRNA122, MCP-1, TGF-β1, PCR

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