Context triggers the retrieval of long-term memories into working memory to guide attention

Summary How do we know what we are looking for in familiar scenes and surroundings? Here we tested a novel hypothesis derived from theories of human memory that working memory (WM) buffers mnemonic contents retrieved from long-term memory (LTM) to control attention. To test this hypothesis, we measured the electrical fields recorded noninvasively from human subjects’ as they searched for specific sets of objects in learned contexts. We found that the subjects’ WM-indexing brain activity tracked the number of real-world objects people learned to search for in each context. Moreover, the level of this WM activity predicted the inter-subject variability in behavioral performance. Together, our results demonstrate that familiar contexts can trigger the transfer of information from LTM to WM to provide top-down attentional control.