BDNF and serum S100B levels according the spectrum of structural pathology in chronic pain patients

Luciana Cadore Stefani, Luciana Paula Cadore Stefani, Fabricio M Leite, Fabrício Moura Leite, Maria da Graça L Tarragó, Maria da Graça Lopes Tarragó, Simone A Zanette, Simone Azevedo Zanette, Andressa de Souza, Stela Maris de Jezus Castro, Stela M Castro, Wolnei Caumo
Neuroscience letters · 2019 · vol. 706 , pp. 105–109 · doi:10.1016/j.neulet.2019.05.021 · PMID:31100426 · W2946253786
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-12 ⓘ

Serum BDNF levels were higher in fibromyalgia and headache patients, while S100B levels were elevated in osteoarthritis and endometriosis patients, suggesting differential neuromodulator involvement in chronic pain conditions.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-12 · read from full text ⓘ

The study measured serum brain-derived neurotrophic factor (BDNF) and S100B in chronic pain women to test whether these neuromodulators differ across the “central sensitivity syndrome” spectrum that includes conditions without overt structural pathology (fibromyalgia, chronic tension-type headache) versus those with recognizable somatic or visceral structural abnormalities (osteoarthritis, endometriosis). Using ANCOVA with heteroscedasticity-consistent covariance, the authors compared BDNF and S100B across 88 osteoarthritis patients, 36 endometriosis patients, 117 fibromyalgia patients, 33 chronic tension-type headache patients, and 41 healthy controls, adjusting for depression severity, pain levels, and analgesic use. Serum BDNF was higher (and not different between fibromyalgia and headache) in the CSS group without structural pathology, whereas S100B was higher in osteoarthritis and endometriosis compared with controls and the non-structural CSS groups. The paper does not explicitly state a limitation in the provided text excerpt. Relevance to endometriosis: endometriosis is included as a visceral structural-pathology subgroup, and the study reports higher serum S100B in endometriosis versus controls and fibromyalgia/tensional headache, though the overall focus is comparing neuromodulator profiles across multiple chronic pain diagnoses.

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BDNF and serum S100B levels according the spectrum of structural pathology in chronic pain patients View/ Open Date 2019Author Type Subject Abstract Central sensitivity syndrome (CSS) consists of adaptive pathophysiological changes associated with neuroplasticity in some chronic pain disorders. It could be grouped in two main conceptual conditions: one includes those chronic pain patients without overt structural pathology such as fibromyalgia, and the other subgroup includes conditions with recognizable structural abnormalities, both somatic (osteoarthritis) and visceral (endometriosis). In order to understand the role of neuromodulators i ... Central sensitivity syndrome (CSS) consists of adaptive pathophysiological changes associated with neuroplasticity in some chronic pain disorders. It could be grouped in two main conceptual conditions: one includes those chronic pain patients without overt structural pathology such as fibromyalgia, and the other subgroup includes conditions with recognizable structural abnormalities, both somatic (osteoarthritis) and visceral (endometriosis). In order to understand the role of neuromodulators in CCS we aim to determine whether brain-derived neurotrophic factor (BDNF) and S100B are associated to specific chronic pain disorders. Serum BDNF and S100B were measured in chronic pain women with different diagnosis: 88 with osteoarthritis, 36 with endometriosis, 117 with fibromyalgia, 33 with chronic tension type headache and in 41 healthy controls. ANCOVA analysis followed by heteroscedasticity-consistent covariance matrix was performed to evaluate BDNF and S100B levels, adjusted for depression severity, pain levels and use of analgesics according different pathologies. Serum BDNF concentrations were higher and not different in patients with fibromyalgia and headache, the CSS group without structural pathology. In contrast, the concentrations of S100B were higher in patients with osteoarthritis and endometriosis, in comparison to controls, fibromyalgia and tensional headache patients. This study supports the hypothesis that BDNF and S100B neuromodulators present different serum levels according to the background disease associated to the chronic pain. These have the potential to be studied as markers of active disease or treatment evolution. ... In Neuroscience letters. Limerick. Vol. 706 (May 2019), p. 105-109 Source Foreign Collections - Journal Articles (45316)Exact and Earth Sciences (6756) This item is licensed under a Creative Commons License

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Condition tags

endometriosis

MeSH descriptors

Brain-Derived Neurotrophic Factor Chronic Pain S100 Calcium Binding Protein beta Subunit Adult Biomarkers Biomarkers Brain-Derived Neurotrophic Factor Chronic Pain Cross-Sectional Studies Endometriosis Endometriosis Female Fibromyalgia Fibromyalgia Humans Osteoarthritis Osteoarthritis S100 Calcium Binding Protein beta Subunit Tension-Type Headache Tension-Type Headache

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