Photoelectrochemical Biosensor Based On 1D ZnIn2S4 Nanosheet Decorated 2D In2O3 Tube For Sensitive PSA Detection

In photoelectrochemical biosensing, efficient electron-hole separation is crucial to obtain preferred photocurrent response and analytical performance; thus, constructing developed heterointerfaces with high carriers transfer efficiency is an effective way for sensitive evaluation of analytes. Herein, 1D ZnIn2S4 nanosheet decorated 2D In2O3 tube was developed to integrate with prostate antigen (PSA)-sensitive aptamer for PSA sensitive detection. Benefiting from photoelectric effect and specific 1D/2D hierarchical structure, In2O3-ZnIn2S4 displayed enhanced optical absorption and photocarrier separation, thus superior photoelectrochemical response. Proposed bioassay protocol possessed the linear range from 0.001 to 50 ng/mL and a detection limit at 0.00037 ng/mL. In addition, this biosensor exhibited satisfy anti-interface ability and stability, which also could be extended to other quantitative platforms for detecting else proteins.