PREOPERATIVE USE OF TESTOSTERONE PROPIONATE AS AN AID TO SURGICAL TREATMENT OF ENDOMETRIOSIS

James R. Miller
In: Journal of the American Medical Association · 1944 · vol. 125(3) , pp. 207 · doi:10.1001/jama.1944.72850210001008 · W2027034682
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⚙ AI-generated summary by claude@2026-07, 2026-07-15 ⓘ

Testosterone propionate was used preoperatively for endometriosis, resulting in suppressed periods, tumor reduction, pain relief, but also masculinizing side effects that regressed after treatment cessation.

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Abstract

In 1940 Wilson1reported the use of testosterone propionate in the treatment of endometriosis of the rectovaginal septum. His patient was 28 years of age and had one child. In a period of thirteen months 4,800 mg. of testosterone was given and he noted (a) suppression of the periods for one year, (b) pronounced but incomplete reduction of the tumor and complete freedom from pain, (c) atrophy of the uterine mucosa, (d) persistent hoarseness, (e) progressive hirsutism and (f) enlargement of the clitoris. After discontinuing the treatment he noted regression of the masculinizing effects and a renewal of tumor growth with recurrence of pain. He did not give the subsequent history. In 1941 Geist and Salmon2reported results from the use of testosterone propionate in 400 cases of functional bleeding and mentioned the rationale of its use in early endometriosis. In 1943 Hirst3reported the use of

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Condition tags

endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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