The clinical significance of pre-operative serum CA 125 in ovarian cancer

Cruickshank DJ, D J Cruickshank, Fullerton WT, W T Fullerton, A. Klopper, Klopper A
British journal of obstetrics and gynaecology · 1987 · doi:10.1111/j.1471-0528.1987.tb03177.x · PMID:2441738
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This prospective study assessed pre-operative serum CA 125 in 52 ovarian cancer patients, finding that levels correlated with tumor load and FIGO stage but not with histopathological grade or prognosis.

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Abstract

In a prospective study of 52 patients with ovarian malignancy followed up for 3-18 months the clinical significance of pre-operative serum CA 125 as a tumour marker was assessed. In 41 patients with epithelial ovarian cancer, the level of CA 125 correlated well with tumour load as indicated by FIGO stage. All epithelial histological types, including mucinous, released CA 125 although serous and undifferentiated tumours produced quantitatively more antigen. There was, however, no correlation between CA 125 concentration and histopathological grade, nor did CA 125 level appear to be of any prognostic value in epithelial ovarian cancer. Elevated CA 125 levels were also found in patients with sex cord/stromal tumours. Krukenberg tumours, an ovarian sarcoma and a serous carcinoma of low malignant potential.

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Condition tags

endometriosis

MeSH descriptors

Antigens, Neoplasm Antigens, Surface Epitopes Ovarian Neoplasms Adenocarcinoma Adenocarcinoma Adenocarcinoma, Mucinous Adenocarcinoma, Mucinous Antigens, Neoplasm Antigens, Surface Antigens, Tumor-Associated, Carbohydrate Cystadenocarcinoma Cystadenocarcinoma Endometriosis Endometriosis Epitopes Female Humans Neoplasm Staging Ovarian Neoplasms

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europepmc
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pubmed
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