Establishment of endometriosis model by abdominal wall subcutaneous injection of endometrium in Lewis rats

Objective To establish a endometriosis model by abdominal subcutaneous injection of endometrium in Lewis rats.Methods Endometrium of Lewis rats was subcutaneously injected into abdominal wall in 28 Lewis rats.On the 7th day and 21st day after surgery,the heterotopic nodules were taken out for HE staining and pathological observation.Results All 28 rats were survived with the ectopic endometrium growing in abdominal wall.The ectopic endometrium nodules grew like a small cystic mass and with the basic organizational structures of normal endometrium under microscope.Conclusion The endometriosis model of Lewis rats has been successfully established,which is beneficial to the study of endometriosis.