Investigation on the Therapeutic Mechanism of Danbie Capsules for Endometriosis: A Network Pharmacology Approach

Zhang L, Wu R, Ma T, Fu W, Chen J, Li L, He Q
2024 · W7048015991
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This network pharmacology study identified quercetin, β-sitosterol, and luteolin as active substances in Danbie Capsules that target TP53 and AKT1 for endometriosis treatment.

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This paper used a network pharmacology approach to identify active substances and molecular targets of Danbie Capsules for endometriosis by screening 183 compounds from TCMSP and published literature and intersecting their predicted targets with endometriosis-related gene targets derived from the GEO database, yielding 24 target genes. Network mapping with Cytoscape and protein–protein interaction analysis using STRING highlighted three critical active substances (quercetin, β-sitosterol, and luteolin) and seven critical targets, with TP53 and AKT1 emphasized and additionally supported by molecular docking and immunohistochemical verification. A major caveat is that the study relies on in silico network analyses and curated database-derived targets before focusing on limited experimentally supported genes. This paper is centrally about endometriosis — it investigates Danbie Capsules’ therapeutic mechanisms via active compound–target network analysis centered on TP53 and AKT1.

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Abstract

Lina Zhang,1– 3,* Ruibin Wu,2,3,* Tenghui Ma,2,3 Wenwen Fu,2,3 Jiamin Chen,2,3 Lingling Li,2,3 Qing He2,3 1The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510080, People’s Republic of China; 2Department of Clinical Nutrition and Microbiome; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, People’s Republic of China; 3Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Ministry of Education, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qing He, Email [email protected]: To explore the active substances and targets of Danbie Capsules in Endometriosis therapy.Methods: This study was conducted through TCMSP and published literature screened and obtained 183 active substances of Danbie Capsules, combined and intersected with Endometriosis target genes collected and screened in the GEO database, obtained 24 target genes for Endometriosis treatment, and mapped the target network map of Danbie Capsules active substances against Endometriosis. The network was analyzed with the aid of Cytoscape version 3.9.1. With the aid of the platform of the STRING data analysis, PPI network analysis was conducted on 24 anti-Endometriosis targets of the Danbie Capsules.Results: The research results obtained three critical active substances, namely, Quercetin, β-sitosterol, and Luteolin. Seven critical targets were identified, and two representative genes (TP53 and AKT1) have been verified in Macromolecular docking and immunohistochemical verification.Conclusion: The active substances of Danbie Capsules in the treatment of Endometriosis are Quercetin, β-sitosterol and Luteolin, and the main targets are TP53 and AKT1.Keywords: danbie capsules, endometriosis, network pharmacology
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International Journal of General Medicine (Jun 2024) Investigation on the Therapeutic Mechanism of Danbie Capsules for Endometriosis: A Network Pharmacology Approach Abstract Lina Zhang,1– 3,* Ruibin Wu,2,3,* Tenghui Ma,2,3 Wenwen Fu,2,3 Jiamin Chen,2,3 Lingling Li,2,3 Qing He2,3 1The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510080, People’s Republic of China; 2Department of Clinical Nutrition and Microbiome; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, People’s Republic of China; 3Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Ministry of Education, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qing He, Email [email protected]: To explore the active substances and targets of Danbie Capsules in Endometriosis therapy.Methods: This study was conducted through TCMSP and published literature screened and obtained 183 active substances of Danbie Capsules, combined and intersected with Endometriosis target genes collected and screened in the GEO database, obtained 24 target genes for Endometriosis treatment, and mapped the target network map of Danbie Capsules active substances against Endometriosis. The network was analyzed with the aid of Cytoscape version 3.9.1. With the aid of the platform of the STRING data analysis, PPI network analysis was conducted on 24 anti-Endometriosis targets of the Danbie Capsules.Results: The research results obtained three critical active substances, namely, Quercetin, β-sitosterol, and Luteolin. Seven critical targets were identified, and two representative genes (TP53 and AKT1) have been verified in Macromolecular docking and immunohistochemical verification.Conclusion: The active substances of Danbie Capsules in the treatment of Endometriosis are Quercetin, β-sitosterol and Luteolin, and the main targets are TP53 and AKT1.Keywords: danbie capsules, endometriosis, network pharmacology

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