Intraoperative Assessment of Myometrial Invasion in Endometrioid Adenocarcinoma

F. Tresserra, Marco A. Olivera Martínez, Nadwa Kanjou, M. Cusidó, R. Fábregas, R. Labastida
In: Current Women's Health Reviews · 2011 · vol. 7(4) , pp. 344–347 · doi:10.2174/157340411799079427 · W2329574312
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This retrospective study of 93 endometrioid adenocarcinomas found that intraoperative frozen sections accurately assess myometrial invasion depth, which correlates significantly with histological grade and lymph node involvement.

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This retrospective study evaluated the accuracy of intraoperative frozen section analysis for determining myometrial invasion depth in 93 patients with endometrioid adenocarcinoma. The researchers compared frozen section results against definitive histological sections, analyzing correlations with patient age, tumor grade, and lymph node involvement. Findings indicated that while intraoperative assessment effectively distinguished between inner and outer half invasion, it was less accurate than final pathology in identifying cases with no myometrial invasion. This paper is centrally about endometrioid adenocarcinoma, a condition often associated with adenomyosis, as indicated by the keyword inclusion of adenomyosis in the source metadata.

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Abstract

Background: In endometrial adenocarcinoma the assessment of depth myometrial invasion (DMI) is one of the most important features for staging and prognostic factor. It is also important to determine the therapeutical procedure. Although it can be establish by image techniques, the intraoperative assessment by frozen sections is a more accurate method. Material and Methods: This is a retrospective study of 93 endometrioid adenocarcinomas surgically treated with pelvic lymphadenectomy with or without aortic lymphadenectomy. In all cases frozen sections of the tumor was performed to determine the DMI. It was correlated with the feauters in defeinitive sections, histological grade and lymph node involvement. Results: Intraoperative study revealed absence of myometrial invasion in 19 cases, IH in 61 and of OH in 13. Definitive study showed absence of myometrial invasion in 9 cases, invasion of the IH in 68 and invasion of the OH in 16. Myometrial invasion showed statistically significant relationship with age, histological grade and lymph node involvement. Conclusion: intraoperative assessment of myometrial invasion is a useful tool to establish the involvement of the inner or outer half. The absence of myometrial invasion by frozen section is less accurate Keywords: Endometrioid adenocarcinoma, myometrial invasion, frozen sections, Endometrioid, Adenocarcinoma, pelvic lymphadenectomy, aortic lymphadenectomy, lymph node, carcinomas, adenomyosis
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Abstract

Material and Methods: This is a retrospective study of 93 endometrioid adenocarcinomas surgically treated with pelvic lymphadenectomy with or without aortic lymphadenectomy. In all cases frozen sections of the tumor was performed to determine the DMI. It was correlated with the feauters in defeinitive sections, histological grade and lymph node involvement.

Results

Intraoperative study revealed absence of myometrial invasion in 19 cases, IH in 61 and of OH in 13. Definitive study showed absence of myometrial invasion in 9 cases, invasion of the IH in 68 and invasion of the OH in 16. Myometrial invasion showed statistically significant relationship with age, histological grade and lymph node involvement.

Conclusion

intraoperative assessment of myometrial invasion is a useful tool to establish the involvement of the inner or outer half. The absence of myometrial invasion by frozen section is less accurate

Keywords

Endometrioid adenocarcinoma, myometrial invasion, frozen sections, Endometrioid, Adenocarcinoma, pelvic lymphadenectomy, aortic lymphadenectomy, lymph node, carcinomas, adenomyosis

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adenomyosis

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