Medical thoracoscopy in thoracic endometriosis: a diagnostic tool in a rare scenario

In: International Journal of Research in Medical Sciences · 2026 · vol. 14(6) , pp. 2620–2624 · doi:10.18203/2320-6012.ijrms20261714 · W7162816128
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Medical thoracoscopy successfully diagnosed thoracic endometriosis in a patient presenting with recurrent right hydropneumothorax and cyclical chest pain and dyspnea, symptoms correlating with menstruation.

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The paper describes a case in which medical thoracoscopy was used to evaluate pleural disease when initial diagnostic steps and conventional therapies were not sufficient, focusing on thoracic endometriosis presenting as catamenial pleural pathology. A 29-year-old woman with secondary infertility and recurrent right-sided chest pain and dyspnea developed right hydropneumothorax on imaging, and because her symptoms tracked cyclically with menstruation, thoracic endometriosis was suspected and confirmed by histopathology obtained via medical thoracoscopy. The main limitation is that this is a single case report, so findings cannot establish broader diagnostic accuracy. This paper is centrally about endometriosis — it presents medical thoracoscopy as a diagnostic tool for thoracic endometriosis in a rare scenario with catamenial symptoms.

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Abstract

Medical thoracoscopy is a tool employed in the evaluation of pleural effusions when initial diagnostic thoracocentesis and standard conventional therapies prove to be ineffective. Thoracic endometriosis (TE) is an uncommon form of extra pelvic endometriosis, characterized by endometrial cells in thoracic cavity which can be parenchymal, pleural and diaphragmatic. TE typically manifest as catamenial pneumothorax followed by catamenial hemothorax, catamenial hemoptysis and occasionally as pulmonary nodules. We present a case involving a 29 year old female experiencing secondary infertility and recurrent right sided chest pain and dyspnea since three months. Chest radiography revealed right hydropneumothorax. As her symptoms correlated cyclically with menstruation, a high suspicion of TE was made and later confirmed on histopathology by medical thoracoscopy.
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Medical thoracoscopy in thoracic endometriosis: a diagnostic tool in a rare scenario DOI: https://doi.org/10.18203/2320-6012.ijrms20261714Keywords: Thoracic endometriosis syndrome, Catamenial pneumothorax, Medical thoracoscopy, Pleural endometriosis, Secondary infertility, Hormonal and surgical managementAbstract Medical thoracoscopy is a tool employed in the evaluation of pleural effusions when initial diagnostic thoracocentesis and standard conventional therapies prove to be ineffective. Thoracic endometriosis (TE) is an uncommon form of extra pelvic endometriosis, characterized by endometrial cells in thoracic cavity which can be parenchymal, pleural and diaphragmatic. TE typically manifest as catamenial pneumothorax followed by catamenial hemothorax, catamenial hemoptysis and occasionally as pulmonary nodules. We present a case involving a 29 year old female experiencing secondary infertility and recurrent right sided chest pain and dyspnea since three months. Chest radiography revealed right hydropneumothorax. As her symptoms correlated cyclically with menstruation, a high suspicion of TE was made and later confirmed on histopathology by medical thoracoscopy. Metrics References Agarwal N, Subramanian A. Endometriosis-morphology, clinical presentations and molecular pathology. J Lab Physicians. 2010;2(1):1-9. DOI: https://doi.org/10.4103/0974-2727.66699 Vinatier D, Orazi G, Cosson M, Dufour P. Theories of endometriosis. Eur J Obstet Gynecol Reprod Biol. 2001;96(1):21-34. DOI: https://doi.org/10.1016/S0301-2115(00)00405-X Alifano M, Trisolini R, Cancellieri A, Regnard JF. Thoracic endometriosis: current knowledge. Ann Thorac Surg. 2006;81(2):761-9. DOI: https://doi.org/10.1016/j.athoracsur.2005.07.044 Joseph J, Sahn SA. Thoracic endometriosis syndrome: new observations from an analysis of 110 cases. Am J Med. 1996;100(2):164-70. DOI: https://doi.org/10.1016/S0002-9343(97)89454-5 Channabasavaiah AD, Joseph JV. Thoracic endometriosis: revisiting the association between clinical presentation and thoracic pathology based on thoracoscopic findings in 110 patients. Medicine (Baltimore). 2010;89(3):183-8. DOI: https://doi.org/10.1097/MD.0b013e3181df67d5 Sampson JA. Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol. 1927;14:422-69. DOI: https://doi.org/10.1016/S0002-9378(15)30003-X Alifano M, Roth T, Broët SC, Schussler O, Magdeleinat P, Regnard JF. Catamenial pneumothorax: a prospective study. Chest. 2003;124(3):1004-8. DOI: https://doi.org/10.1378/chest.124.3.1004 Makhija Z, Marrinan M. A case of catamenial pneumothorax with diaphragmatic fenestrations. J Emerg Med. 2012;43(1):e1-3. DOI: https://doi.org/10.1016/j.jemermed.2009.05.023 Maurer ER, Schaal JA, Mendez FL Jr. Chronic recurring spontaneous pneumothorax due to endometriosis of the diaphragm. JAMA. 1958;168(15):2013-4. DOI: https://doi.org/10.1001/jama.1958.63000150008012c Fukunaga M. Paratesticular endometriosis in a man with prolonged hormonal therapy for prostatic carcinoma. Pathol Res Pract. 2012;208(1):59-61. DOI: https://doi.org/10.1016/j.prp.2011.10.007 Joseph J, Reed CE, Sahn SA. Thoracic endometriosis: recurrence following hysterectomy with bilateral salpingo-oophorectomy and successful treatment with talc pleurodesis. Chest. 1994;106(6):1894-6. DOI: https://doi.org/10.1378/chest.106.6.1894 Nwiloh J. Diaphragmatic patch: a useful adjunct in surgical treatment of recurrent catamenial hemothorax. Rev Port Pneumol. 2011;17(6):278-80. DOI: https://doi.org/10.1016/j.rppnen.2011.11.006 Hibbard LT, Schumann WR, Goldstein GE. Thoracic endometriosis: a review and report of two cases. Am J Obstet Gynecol. 1981;140(2):227-32. DOI: https://doi.org/10.1016/0002-9378(81)90112-5 Chatterjee S, Mukhoti K, Chakraborty A. Catamenial pneumothorax in thoracic endometriosis syndrome. Lung India. 2024;41(3):217-8. DOI: https://doi.org/10.4103/lungindia.lungindia_576_23 Sharma P, Karmakar S, Wani AR, Venugopal V, Maji D. Thoracic endometriosis syndrome diagnosed by dry thoracoscopy: Novel diagnostic method for a rare disease. Lung India. 2025;42(2):147-50. DOI: https://doi.org/10.4103/lungindia.lungindia_576_24 Hope-Gill B, Prathibha B. Catamenial haemoptysis and clomiphene citrate therapy. Thorax. 2003;58(1):89. DOI: https://doi.org/10.1136/thorax.58.1.89 Chetambath R, Karedath G, Chandran S. Thoracic Endometriosis Detected During Medical Thoracoscopy in a Tertiary Care Setting-A Retrospective Observational Study. J Pulmonol Res Rep. 2024;6(4):1-4. DOI: https://doi.org/10.47363/JPRR/2024(6)172 Nezhat C, Nicoll LM, Bhagan L, Huang JQ, Bosev D, Hajhosseini B, et al. Endometriosis of the diaphragm: four cases treated with a combination of laparoscopy and thoracoscopy. J Minimally Invas Gynecol. 2009;16(5):573-80. DOI: https://doi.org/10.1016/j.jmig.2009.06.012 Light RW. Pleural disease. 5th edition. Lippincott Williams and Wilkins: Baltimore. 2007.

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