COMPARATIVE CHARACTERISTICS OF THE AVAILABLE LABORATORY TESTS AND THEIR COMBINATIONS USED IN DIFFERENTIAL DIAGNOSIS OF OVARIAN NEOPLASMS

About the Authors M. A. EgunovaRussian Federation Egunova Mariya Alekseevna – Postgraduate student, Department of Obstetrics and Gynecology. Moskovskiy trakt, 2, Tomsk, 634050. I. G. Kutsenko Russian Federation Kutsenko Irina Georgievna – MD, Professor, Department of Obstetrics and Gynecology. Moskovskiy trakt, 2, Tomsk, 634050. in

1. Malignant neoplasms in Russia in 2014 (morbidity and mortality) [Zlokachestvennye novoobrazovaniya v Rossii v 2014 godu (zabolevaemost' i smertnost') (Pod red. A.D. Kaprina, V.V. Starinskogo, G.V. Petrovoj)]. Moskva: MNIOI im. P.A. Gercena – filial FGBU «NMIRC» MZ RF. 2016: 250 s (in Russian). 2. Malignant neoplasms in Russia in 2015 (morbidity and mortality) [Zlokachestvennye novoobrazovaniya v Rossii v 2015 godu (zabolevaemost' i smertnost') (Pod red. A.D. Kaprina, V.V. Starinskogo, G.V. Petrovoj)]. Moskva: MNIOI im. P.A. Gercena – filial FGBU «NMIRC» MZ RF. 2017: 250 s (in Russian). 3. Axel E.M. Morbidity and mortality from malignant neoplasms of the female reproductive system in Russia [Zabolevaemost' i smertnost' ot zlokachestvennyh novoobrazovanij organov zhenskoj reproduktivnoj sistemy v Rossii]. Onkoginekologiya. 2015; 1: 6-15 (in Russian). 4. Molina R., Escudero J.M., Auge J.M. et al. HE4 a novel tumour marker for ovarian cancer: comparison with CA 125 and ROMA algorithm in patients with gynecological diseases. Tumour Biol. 2011; 32 (6): 1087-95. 5. Anton C., Carvalho F.M., Oliveira E.I. et al. A comparison of CA125, HE4, risk ovarian malignancy algorithm (ROMA), and risk malignancy index (RMI) for the classification of ovarian masses. Clinics (Sao Paulo). 2012; 67 (5): 437-41. 6. Dodge J.E., Covens A.L., Lacchetti C. et al. Preoperative identification of a suspicious adnexal mass: a systematic review and meta-analysis. Gynecol Oncol. 2012; 126 (1): 157-66. 7. Martynov S.A. Modern oncomarkers in differential diagnosis of ovarian tumors outside and during pregnancy (literature review) [Sovremennye onkomarkery v differencial'noj diagnostike opuholej yaichnikov vne i vo vremya beremennosti (obzor literatury)]. Ginekologiya. 2014; 16 (4): 63-7 (in Russian). 8. Nikoghosyan S.O., Kadagidze Z.G., Shelepova V.M., Kuznetsov V.V. Modern methods of immunodiagnosis of malignant neoplasms of the ovaries [Sovremennye metody immunodiagnostiki zlokachestvennyh novoobrazovanij yaichnikov]. Onkoginekologiya. 2014; 3: 49-54 (in Russian). 9. Johnson C.C., Kessel B., Riley T.L. et al. The epidemiology of CA-125 in women without evidence of ovarian cancer in the Prostate, Lung, Colorectal and Ovarian Cancer (PLCO) Screening Trial. Gynecol Oncol. 2008; 110 (3): 383-9. 10. Huhtinen K., Suvitie P., Hiissa J. et al. Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts. Br J Cancer. 2009; 100 (8): 1315-19. 11. Kalapotharakos G., Asciutto C., Henic E. et al. High preoperative blood levels of HE4 predicts poor prognosis in patients with ovarian cancer. J Ovarian Res. 2012; 5 (1): 20. 12. Moore R.G., Brown A.K., Miller M.C. et al. Utility of a novel serum tumor biomarker HE4 in patients with endometrioid adenocarcinoma of the uterus. Gynecol Oncol. 2008; 110 (2): 196-201. 13. Severskaya N.V., Chebotareva I.V., Sychenkova N.I. et al. Tumor markers CA-125, HE4 and ROMA in differential diagnosis of ovarian cancer in pre- and postmenopausal women [Opuholevye markery СA-125, НE4 i ROMA v differencial'noj diagnostike raka yaichnika u zhenshchin v pre- i postmenopauze. I Nacional'nyj kongress «Onkologiya reproduktivnyh organov: ot profilaktiki i rannego vyyavleniya k effektivnomu lecheniyu»: tezisy dokladov]. Moskva: KVAZAR. 2016: 143 (in Russian). 14. Van Gorp T., Cadron I., Despierre E. et al. HE4 and CA 125 as a diagnostic test in ovarian cancer: prospective validation of the Risk of Ovarian Malignancy Algorithm. Br J Cancer. 2011; 104 (5): 863-70. 15. Borisova E.A., Makarenko T.A., Bulanov M.N. Problems of early differential diagnosis of benign and malignant ovarian formations [Problemy rannej differencial'noj diagnostiki dobrokachestvennyh i zlokachestvennyh obrazovanij yaichnikov. I Nacional'nyj kongress «Onkologiya reproduktivnyh organov: ot profilaktiki i rannego vyyavleniya k effektivnomu lecheniyu»: tezisy dokladov]. Moskva: KVAZAR. 2016: 47 (in Russian). 16. О rder of Health Ministry of Russian Federation from 01.11.2012 № 572n «On Approval of the Procedure for the provision of medical assistance in “obstetrics and gynecology (excluding the use of assisted reproductive technologies)”» [Prikaz Ministerstva zdravoohraneniya Rossijskoj Federacii ot 01.11.2012 g. № 572n «Ob utverzhdenii Poryadka okazaniya medicinskoj pomoshchi po profilyu “akusherstvo i ginekologiya (za isklyucheniem ispol'zovaniya vspomogatel'nyh reproduktivnyh tekhnologij)”» (in Russian). URL: http://legalacts.ru/doc/prikaz-minzdrava-rossii-ot01112012-n-572n/ [Accessed: 08.09.2017]. 17. Tingulstad S., Hagen B., Skjeldestad F.E. et al. Evaluation of a risk of malignancy index based on serum CA125, ultrasound findings and menopausal status in the pre-operative diagnosis of pelvic masses. Br J Obstet Gynaecol. 1996; 103 (8): 826-31. 18. Calculation of ROMA algorithm [Raschet algoritma ROMA] (in Russian). URL: http://romatools.he4test.com/calculator_row_ en.html [Accessed: 08.09.2017]. 19. Moore R.G., McMeekin D.S., Brown A.K. et al. A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass. Gynecol Oncol. 2009; 112 (1): 40-6. 20. Jacobs I., Oram D., Fairbanks J. et al. A risk of malignancy index incorporating CA 125, ultrasound and menopausal status for the accurate preoperative diagnosis of ovarian cancer. Br J Obstet Gynaecol. 1990; 97 (10): 922-9. 21. Hakansson F., Hodgall E.V., Nedergaard L. et al. Risk of malignancy index used as a diagnostic tool in a tertiary centre for patients with pelvic mass. Acta Obstet Gynecol Scand. 2012; 91 (4): 496-502. 22. Karlsen M.A., Sandhu N., Hodgall C. et al. Evaluation of HE4, CA125, risk of ovarian malignancy algorithm (ROMA) and risk of malignancy index (RMI) as diagnostic tools of epithelial ovarian cancer patients with pelvic mass. Gynecol Oncol. 2012; 127 (2): 379-83. 23. Holcomb K., Vucetic Z., Miller M.C., Knapp R.C. Human epididymis protein 4 offers superior specificity in the differentiation of benign and malignant adnexal masses in premenopausal women. Am J Obstet Gynecol. 2011; 205 (4): 358. 24. Barbati A., Lauro V., Orlacchio A., Cosmi E.V. Immunoblotting characterization of CA 125 in biological fluids: difference between pregnancy and cancer CA 125 origin. Anticancer Res. 1996; 16 (6B): 3621-4. 25. Bast R.C., Urban N., Shridhar V. et al. Early detection of ovarian cancer: promise and reality. Cancer Treat Res. 2002; 107: 61-97. 26. Nikoghosyan S.O., Kuznetsov V.V. Modern diagnosis of ovarian cancer [Sovremennaya diagnostika raka yaichnikov]. Rossijskij onkologicheskij zhurnal. 2013; 5: 52-6 (in Russian). 27. Sergeeva N.S., Alentov I.I., Marshutina N.V. Epididymis protein of human HE4 as a new tumor-associated marker [Belok epididimisa cheloveka NE4 kak novyj opuholeassociirovannyj marker]. Onkoginekologiya. 2016; 4: 48-58 (in Russian). 28. Galgano M.T., Hampton G.M., Frierson H.F. Jr. Comprehensive analysis of HE4 expression in normal and malignant human tissues. Mod Pathol. 2006; 19 (6): 847-53. 29. Georgakopoulos P., Mehmood S., Akalin A., Shroyer K.R. Immunohistochemical localization of HE4 in benign, border-line, and malignant lesions of the ovary. Int J Gynecol Pathol. 2012; 31 (6): 517-23. 30. Park Y., Lee J.H., Hong D.J. et al. Diagnostic performances of HE4 and CA125 for the detection of ovarian cancer from patients with various gynecologic and non-gynecologic diseases. Clin Biochem. 2011; 44 (10-11): 884-8. 31. Macedo A.C., da Rosa M.I., Lumertz S., Medeiros L.R. Accuracy of serum human epididymis protein 4 in ovarian cancer diagnosis: a systematic review and metaanalysis. Int J Gynecol Cancer. 2014; 24 (7): 1222-31. 32. Gerfanova E.V., Ashrafyan L.A., Antonova I.B. et al. Ovarian Cancer Screening: Reality and Prospects. Literature review [Skrining raka yaichnikov: real'nost' i perspektivy. Obzor literatury]. Opuholi zhenskoj reproduktivnoj sistemy. 2015; 11(1): 69-75 (in Russian). Review For citations: Egunova M.A., Kutsenko I.G. COMPARATIVE CHARACTERISTICS OF THE AVAILABLE LABORATORY TESTS AND THEIR COMBINATIONS USED IN DIFFERENTIAL DIAGNOSIS OF OVARIAN NEOPLASMS. Obstetrics, Gynecology and Reproduction. 2017;11(4):5-13. (In Russ.) https://doi.org/10.17749/2313-7347.2017.11.4.005-013 JATS XML This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.