[The Expression of microRNA-221 in Endometriosis and Its Impact on Endometrial Stromal Cells].

Xiaohang Du, Xiao-Hang Du, Gang Shi, Donghao Lu, Dong-Hao Lü, Yu-He Wang, Yuhe Wang, Jie-Ting Chen, Jieting Chen, Qian Zheng, Xia Yin, Yin Xia
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2018 · vol. 49(4) , pp. 546–550 · PMID:30378307 · W3024843925
article OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found that microRNA-221 is downregulated in endometriosis tissues and that its restoration inhibits the proliferation of ectopic endometrial stromal cells.

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Abstract

OBJECTIVE: To determine the expression of microRNA-221 (miR-221) in endometrial tissues and its impact on the proliferation of ectopic endometrial stromal cells. METHODS: ) and cell proliferations were compared with those of the negative control (NC, 10 nmol/L). RESULTS: =0.021). CONCLUSION: expression and decreased cell proliferation in endometrial stromal cells.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis MicroRNAs Stromal Cells Cell Proliferation Endometriosis Endometrium Endometrium Female Humans MicroRNAs PTEN Phosphohydrolase PTEN Phosphohydrolase Stromal Cells Stromal Cells

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