Fully-Biodegradable and Self-Deployable Electronic Tent for Brain Cortex

Abstract The large-area and high-density electronic interfaces for the cortex stands as a crucial enabler for brain-computer interfaces, facilitating synchronization between cognitive functions and motor activities, as well as aiding in the diagnosis neuropathic brain disorders in the realm of cognitive neuroscience and clinical neurology. Nevertheless, the current implantation procedures pose significant challenges that, subject patients to invasiveness throughout the entire interventional procedure. Here, we introduce a fully-biodegradable and self-deployable platform with multimodal inorganic electronics, which can be programmably-packaged and self-deployed using syringe for minimally invasive delivery through a small hole. After use, it naturally decomposes within the body, minimizing invasiveness from initial insertion surgery to subsequent removal. In vivo demonstration shows the potential of minimally invasive cortical-interfacing platform for manipulating large areas of cortical activities.