A Novel Multi-strain Vaginal Synbiotic is Effective in Optimizing the Vaginal Microbiome: Results from a Randomized, Placebo-controlled Clinical Trial

This research letter describes the results of a clinical trial of a novel vaginal synbiotic comprising three L. crispatus strains and a supportive nutrient complex. Results indicated that administration of the synbiotic led to an optimal vaginal microbiome dominated by L. crispatus (CST I) and additionally reduced the abundance of microbes associated with vaginal dysbiosis and the abundance of Candida , the most common source of vaginal yeast infections.