Diagnostic, Prognostic, and Immunological Roles of CD177 in Cervical Cancer

Background: CD177, an indicator of prognosis in diverse cancers, is involved in the physiological processes of various tumor cells, and acts as an immune molecule with novel functions in cancer pathogenesis. However, the diagnostic, prognostic and immunological role of CD177 in cervical cancer remains unclear. Methods. Utilizing publicly available databases and integrating several bioinformatics analysis methods, we evaluated the expression level of CD177 in cervical cancer by GENT2, HPA and GEO databases. The Kaplan–Meier Plotter database, Xena Shiny and the constructed of a nomogram were clearly demonstrated its prognostic value for patients. Gene set enrichment analysis explored the relationship between CD177 and cervical cancer immune responses and immune cells infiltration level. In addition, we investigated the association between CD177 expression and stromalscore, immunescore, immune checkpoint and drug sensitivity by TCGA RNA-seq data. Results. CD177 was apparently expressed at low levels in cervical cancer and predicted a poor survival rate for patients. CD177 significantly activated immune-related signaling pathways and had a positive relationship with immune cell infiltration level. The high CD177 expression group possessed the high stromalscore and immunescore. CD177 had potential interactions with CTLA4, CD27, BLTA, CD200R1, CD80, NRP1, TNFRSF25, TIGIT, ICOS and TNFSF9 checkpoint markers. And CD177 expression was positively relevant with drug sensitivity for Lapatinib, Belinostat, ATRA, Gefitinib, Navitoclax and Tamoxifen. Significance. These findings may shed light on the vital role of CD177 in cervical cancer diagnosis, prognosis, and immunological function, and it may be a promising predictor and potential factor for cervical cancer patients.