Combination resveratrol with exercise training has anti-aging function only at mature stage SAMP8 mice liver

Background: Aging of the liver was regarded as a successful adaptation or as a progressive disease state remains a matter of controversy. This study aims to approach the mature investigation to determine the mature effects of exercise training, resveratrol intake, and the combination on SAMP8 mice liver. Methods: : Histological of 3- and 6-month-old SAMP8 mice were examined by H&E and Masson’s trichrome staining. Apoptosis cells were determined by TUNEL staining. Examine molecular protein of p-PI3K/PI3K, p-Akt/Akt, Bad, cytochrome c, Bcl 2, ERK1, IL-6, STAT3, MEK5, p-ERK5/ERK5, FGF2, and MMP2 by western blotting. Results: : Results showed that the cross-sections of 6-month-old SAMP8 mice livers observed lower adipocytes, collagen, and apoptosis cells appeared after exercise training, resveratrol intake, and their combination than 3-month-old SAMP8 mice. Combination habitual exercise training and resveratrol intake in the 6-month-old SAMP8 mice liver has significant increases in p-PI3K/PI3K (p<0.001) and p-Akt/Akt (p<0.01) ratios compared to 3-month-old SAMP8 mice. Exercise training, resveratrol intake, and combined exercise training and resveratrol intake facilitated ERK1-Bcl2 increases, and Bad, Cytochrome c, IL-6-STAT3-MEK5-p-ERK5/ERK5 and FGF2-MMP2 decreases in the 6-month-old SAMP8, but not 3-month-old SAMP8 mice liver. Conclusion: Fortunately, habitual exercise training and resveratrol intake combination observed in the liver of mature SAMP8 mice at 6 months of age has an excellent good reversed age interaction function in mature SAMP8 mice liver.