A higher anti-Müllerian hormone level is associated with an increased chance of pregnancy in patients undergoing controlled ovarian stimulation and intrauterine insemination

Ming-Ju Wang, M-H Wang, C-H Chen, Chia‐Hung Chen, C.-W. Wang, C-W Wang, M.-I. Hsu, M-I Hsu, C-R Tzeng, Chii‐Ruey Tzeng
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2014 · vol. 35(1) , pp. 64–68 · doi:10.3109/01443615.2014.935718 · PMID:25010731 · W2108625798
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Abstract

Anti-Müllerian hormone (AMH) level has been found to be a useful marker of ovarian reserve, and a predictor of poor and hyper-responses in patients undergoing controlled ovarian stimulation (COS). The study aimed to determine the association of serum AMH level with achieving pregnancy in patients undergoing COS with intrauterine insemination. The cross-sectional study investigated 204 patients who underwent COS with intrauterine insemination at the Obstetrics and Gynecology Department of Taipei Medical University Hospital, from January 2011 to March 2012. The medical records of these patients were reviewed, and serum AMH levels were evaluated for association with successful clinical pregnancy. The AMH level in the patients who achieved clinical pregnancy was significantly higher than in patients who did not (median 2.7 vs 2.0 ng/ml, p = 0.005). Controlling for factors affecting infertility, AMH level had a significant independent influence on outcome; a higher AMH level was associated with a decreased risk of a non-pregnant outcome (odds ratio, OR = 0.895, p = 0.026). In patients undergoing COS and intrauterine insemination, a low AMH level is associated with a decreased chance of a clinical pregnancy, and this association remains irrespective of the presence or absence of endometriosis.

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endometriosisinfertility

MeSH descriptors

Anti-Mullerian Hormone Insemination, Artificial Ovulation Induction Adult Anti-Mullerian Hormone Cross-Sectional Studies Estradiol Estradiol Female Humans Insemination, Artificial Male Ovulation Induction Pregnancy Retrospective Studies

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