Impacts of Xiaoyi Formula on the Expressions of Survivin and Caspase-3 for the Rats with Endometriosis

Objective To observe the impacts of xiaoyi formula on the expression of survivin and caspase-3 for the rats with endometriosis(EM)and explore initially the mechanism of EM so as to provide the important evidence for clinical practice.Methods 80 female rats after modeling were divided randomly into a blank control group,a sham-operation group,a model group,a sanjie zhentong capsules group,a mifepristone group,a low-dose xiaoyi formula group,a middle-dose xiaoyi formula group and a high-dose xiaoyi formula group.Totally,8 groups were included.In 28 days of gastric infusion,the normal uterine and ectopic endometrial tissues were collected.Immunohistochemical assay was adopted to detect the changes in survivin and caspase-3 expressions.Results The apoptosis gene survivin expression in ectopic endometrial tissue in each xiaoyi formula group was significantly different in statistics as compared with model group(P0.05 or P0.01).The expression of caspase-3 was different statistically as compared with model group(P0.05).Conclusion Through activating caspase plasminogen activity and reducing survivin high-expression in the cells,xiaoyi formula affects the apoptosis of ectopic endometrial cells and inhibits ectopic endometrial increase.